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Improved survival in women with BRCA-associated ovarian carcinoma†

  1. Ilana Cass M.D.1,‡,*,
  2. Rae Lynn Baldwin Ph.D.1,
  3. Taz Varkey M.D.1,
  4. Roxana Moslehi Ph.D.2,
  5. Steven A. Narod M.D.2,
  6. Beth Y. Karlan M.D.1

Article first published online: 17 APR 2003

DOI: 10.1002/cncr.11310

Issue

Cancer

Cancer

Volume 97, Issue 9, pages 2187–2195, 1 May 2003

Additional Information

How to Cite

Cass, I., Baldwin, R. L., Varkey, T., Moslehi, R., Narod, S. A. and Karlan, B. Y. (2003), Improved survival in women with BRCA-associated ovarian carcinoma. Cancer, 97: 2187–2195. doi: 10.1002/cncr.11310

Author Information

  1. 1

    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center and University of California-Los Angeles School of Medicine, Los Angeles, California

  2. 2

    Center for Research in Women's Health, Sunnybrook Women's College Health Science Center, University of Toronto, Canada

  1. ‡

    Fax: (310) 423-0155

*Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048

  1. †

    See related editorial on pages 2127–9, this issue.

Publication History

  1. Issue published online: 17 APR 2003
  2. Article first published online: 17 APR 2003
  3. Manuscript Accepted: 18 DEC 2002
  4. Manuscript Revised: 9 DEC 2002
  5. Manuscript Received: 11 NOV 2002

Funded by

  • Gynecologic Cancer Foundation/Susan G. Komen Breast Cancer Foundation
  • American Cancer Society, California Division Inc.. Grant Number: 5-3-00
  • Cedars-Sinai Research for Womens Cancers

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REFERENCES

  • 1
    Risch HA, McLaughlin JR, Cole DEC, et al. Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet. 2001; 68: 700–710.
  • 2
    Abeliovich D, Kaduri L, Lerer I, et al. The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women. Am J Hum Genet. 1997; 60: 505–514.
  • 3
    Levy-Lahad E, Catane R, Eisenberg S, et al. Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families. Am J Hum Genet. 1997; 60: 1059–1067.
  • 4
    Moslehi R, Chu W, Karlan B, et al. BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer. Am J Hum Genet. 2000; 66: 1259–1272.
  • 5
    Struewing JP, Abeliovich D, Peretz T, et al. The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals. Nat Genet. 1995; 11: 198–200.
  • 6
    Oddoux C, Struewing JP, Clayton CM, et al. The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%. Nat Genet. 1996; 14: 188–190.
  • 7
    Narod SA, Ford D, Devilee P, et al. An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium. Am J Hum Genet. 1995; 56: 254–264.
  • 8
    Ford D, Easton DF, Stratton M, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet. 1998; 62: 676–689.
  • 9
    Ford D, Easton DF, Bishop DT, Narod SA, Goldgar DE. Risks of cancer in BRCA1 mutation carriers. Breast Cancer Linkage Consortium. Lancet. 1994; 343: 692–695.
  • 10
    Struewing JP, Lerman C, Kase RG, Giambarresi TR, Tucker MA. Anticipated uptake and impact of genetic testing in hereditary breast and ovarian cancer families. Cancer Epidemiol Biomarkers Prevent. 1995; 4: 169–173.
  • 11
    Brose MS, Rebbeck TR, Calzone KA, Stopfer JE, Nathanson KL, Weber BL. Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program. J Natl Cancer Inst. 2002; 94: 1365–1372.
  • 12
    Hartman AR, Ford JM. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Nat Genet. 2002; 32: 180–184.
  • 13
    Yang H, Jeffrey PD, Miller J, et al. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science. 2002; 297: 1837–1848.
  • 14
    Xu X, Weaver Z, Linke SP, et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999; 3: 389–395.
  • 15
    Thompson ME, Jensen RA, Obermiller PS, Page DL, Holt JT. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet. 1995; 9: 444–450.
  • 16
    Hakem R, de la Pompa JL, Sirard C, et al. The tumor suppressor gene BRCA1 is required for embryonic cellular proliferation in the mouse. Cell. 1996; 85: 1009–1023.
  • 17
    Ramus SJ, Bobrow LG, Pharoah PD, et al. Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours. Genes Chromosomes Cancer. 1999; 25: 91–96.
    Direct Link:
  • 18
    Rhei E, Bogomolniy F, Federici MG, et al. Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers. Cancer Res. 1998; 58: 3193–3196.
  • 19
    Buller RE, Anderson B, Connor JP, Robinson R. Familial ovarian cancer. Gynecol Oncol. 1993; 51: 160–166.
  • 20
    Hedenfalk I, Duggan D, Chen Y, et al. Gene-expression profiles in hereditary breast cancer. N Engl J Med. 2001; 344: 539–548.
  • 21
    Tirkkonen M, Johannsson O, Agnarsson BA, et al. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations. Cancer Res. 1997; 57: 1222–1227.
  • 22
    Boyd J, Sonoda Y, Federici MG, et al. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA. 2000; 283: 2260–2265.
  • 23
    Ben David Y, Chetrit A, Hirsh-Yechezkel G, et al. Effect of BRCA mutations on the length of survival in epithelial ovarian tumors. J Clin Oncol. 2002; 20: 463–466.
  • 24
    Rubin SC, Benjamin I, Behbakht K, et al. Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1 [see comments]. N Engl J Med. 1996; 335: 1413–1416.
  • 25
    Aida H, Takakuwa K, Nagata H, et al. Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1. Clin Cancer Res. 1998; 4: 235–240.
  • 26
    Johannsson OT, Ranstam J, Borg A, Olsson H. Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden. J Clin Oncol. 1998; 16: 397–404.
  • 27
    Pharoah PD, Easton DF, Stockton DL, Gayther S, Ponder BA. Survival in familial, BRCA1-associated, and BRCA2-associated epithelial ovarian cancer. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group. Cancer Res. 1999; 59: 868–871.
  • 28
    Husain A, He G, Venkatraman ES, Spriggs DR. BRCA1 up-regulation is associated with repair-mediated resistance to cis-diamminedichloroplatinum(II). Cancer Res. 1998; 58: 1120–1123.
  • 29
    Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks. Science. 1999; 286: 1162–1166.
  • 30
    Bloss JD, Liao SY, Buller RE, et al. Extraovarian peritoneal serous papillary carcinoma: a case-control retrospective comparison to papillary adenocarcinoma of the ovary. Gynecol Oncol. 1993; 50: 347–351.
  • 31
    Karlan BY, Baldwin RL, Lopez-Luevanos E, et al. Peritoneal serous papillary carcinoma, a phenotypic variant of familial ovarian cancer: implications for ovarian cancer screening. Am J Obstet Gynecol. 1999; 180: 917–928.
  • 32
    Orr JW Jr., Orr P, Kern DH. Cost-effective treatment of women with advanced ovarian cancer by cytoreductive surgery and chemotherapy directed by an in vitro assay for drug resistance. Cancer J Sci Am. 1999; 5: 174–178.
  • 33
    Eltabbakh GH, Piver MS, Hempling RE, et al. Correlation between extreme drug resistance assay and response to primary paclitaxel and cisplatin in patients with epithelial ovarian cancer. Gynecol Oncol. 1998; 70: 392–397.
  • 34
    Kern DH, Weisenthal LM. Highly specific prediction of antineoplastic drug resistance with an in vitro assay using suprapharmacologic drug exposures. J Natl Cancer Inst. 1990; 82: 582–588.
  • 35
    Gotlieb WH, Friedman E, Bar-Sade RB, et al. Rates of Jewish ancestral mutations in BRCA1 and BRCA2 in borderline ovarian tumors. J Natl Cancer Inst. 1998; 90: 995–1000.
  • 36
    Leitao M, Boyd J. Preoperative CA-125 levels in patients with hereditary compared to sporadic epithelial ovarian carcinoma. Gynecol Oncol. 2002; 84: 413–415.
  • 37
    Chang J, Fryatt I, Ponder B, Fisher C, Gore ME. A matched control study of familial epithelial ovarian cancer: patient characteristics, response to chemotherapy and outcome. Ann Oncol. 1995; 6: 80–82.
  • 38
    Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL, Montz FJ. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol. 2002; 20: 1248–1259.
  • 39
    Scully R, Chen J, Plug A, et al. Association of the BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997; 88: 265–275.
  • 40
    Levine DA, Federici MG, Reuter VE, Boyd J. Cell proliferation and apoptosis in BRCA-associated hereditary ovarian cancer. Gynecol Oncol. 2002; 85: 431–434.
  • 41
    Hakem R, de la Pompa JL, Elia A, Potter J, Mak TW. Partial rescue of BRCA1 (5–6) early embryonic lethality by p53 or p21 null mutation. Nat Genet. 1997; 16: 298–302.
  • 42
    Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of BRCA1, BRCA2, BRCA1/BRCA2, BRCA1/p53, and BRCA2/p53 nullizygous embryos. Genes Dev. 1997; 11: 1226–41.
  • 43
    Lane DP. Cancer. p53, guardian of the genome. Nature. 1992; 358: 15–16.
  • 44
    Zhang H, Somasundaram K, Peng Y, et al. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene. 1998; 16: 1713–1721.
  • 45
    Crook T, Brooks LA, Crossland S, et al. p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours. Oncogene. 1998; 17: 1681–1689.
  • 46
    Reedy MB, Hang T, Gallion H, Arnold S, Smith SA. Antisense inhibition of BRCA1 expression and molecular analysis of hereditary tumors indicate that functional inactivation of the p53 DNA damage response pathway is required for BRCA-associated tumorigenesis. Gynecol Oncol. 2001; 81: 441–446.
  • 47
    Crook T, Crossland S, Crompton MR, Osin P, Gusterson BA. p53 mutations in BRCA1-associated familial breast cancer. Lancet. 1997; 350: 638–639.
  • 48
    Phillips KA, Nichol K, Ozcelik H, et al. Frequency of p53 mutations in breast carcinomas from Ashkenazi Jewish carriers of BRCA1 mutations. J Natl Cancer Inst. 1999; 91: 469–473.
  • 49
    Wen WH, Reles A, Runnebaum IB, et al. p53 mutations and expression in ovarian cancers: correlation with overall survival. Int J Gynecol Pathol. 1999; 18: 29–41.
  • 50
    Hartmann LC, Podratz KC, Keeney GL, et al. Prognostic significance of p53 immunostaining in epithelial ovarian cancer. J Clin Oncol. 1994; 12: 64–69.
  • 51
    Buttitta F, Marchetti A, Gadducci A, et al. p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study. Br J Cancer. 1997; 75: 230–235.
  • 52
    Righetti SC, Della Torre G, Pilotti S, et al. A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Cancer Res. 1996; 56: 689–693.
  • 53
    Hartmann LC, Sellers TA, Schaid DJ, et al. Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers. J Natl Cancer Inst. 2001; 93: 1633–1637.
  • 54
    Grann VR, Jacobson JS, Thomason D, Hershman D, Heitjan DF, Neugut AI. Effect of prevention strategies on survival and quality-adjusted survival of women with BRCA1/2 mutations: an updated decision analysis. J Clin Oncol. 2002; 20: 2520–2529.
  • 55
    Aziz S, Kuperstein G, Rosen B, et al. A genetic epidemiological study of carcinoma of the fallopian tube. Gynecol Oncol. 2001; 80: 341–345.
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