Ovarian cancer is the fifth most commonly diagnosed cancer among women in the U.S. Similar to breast and endometrial cancers, ovarian cancer is more common among women in northern and central Europe, and in North America compared with Africa, South America, and Asia. In the U.S., substantial racial and ethnic variations have been observed in the incidence of ovarian cancer. This analysis substantiates higher risk of ovarian cancer among white women and women who are not Hispanic than among black, American Indian, Asian/Pacific Islander, and Hispanic women.