Original Article

You have full text access to this OnlineOpen article

Adenosquamous histology predicts a poor outcome for patients with advanced-stage, but not early-stage, cervical carcinoma†‡

  1. John H. Farley M.D.1,§,*,
  2. Kimberly W. Hickey M.D.1,
  3. Jay W. Carlson D.O.2,
  4. G. Scott Rose M.D.2,
  5. Edward R. Kost M.D.3,
  6. Terry A. Harrison M.D.4

Article first published online: 17 APR 2003

DOI: 10.1002/cncr.11371

Issue

Cancer

Cancer

Volume 97, Issue 9, pages 2196–2202, 1 May 2003

Additional Information

How to Cite

Farley, J. H., Hickey, K. W., Carlson, J. W., Rose, G. S., Kost, E. R. and Harrison, T. A. (2003), Adenosquamous histology predicts a poor outcome for patients with advanced-stage, but not early-stage, cervical carcinoma. Cancer, 97: 2196–2202. doi: 10.1002/cncr.11371

Author Information

  1. 1

    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Tripler Army Medical Center, Honolulu, Hawaii

  2. 2

    Department of Gynecologic Oncology, Walter Reed Army Medical Center, Washington, DC

  3. 3

    Department of Gynecologic Oncology, Brooke Army Medical Center, San Antonio, Texas

  4. 4

    Department of Gynecologic Oncology, Naval Medical Center, San Diego, California

  1. §

    Fax: (808) 433-1552

*Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Tripler Army Medical Center, 1 Jarrett White Road TAMC, Honolulu, HI 96859-5000

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

  2. ‡

    The views expressed herein are those of the authors and do not reflect the official policy or opinion of the Department of Defense, the United States Army, or the United States Navy.

Publication History

  1. Issue published online: 17 APR 2003
  2. Article first published online: 17 APR 2003
  3. Manuscript Accepted: 21 JAN 2003
  4. Manuscript Revised: 30 DEC 2002
  5. Manuscript Received: 4 NOV 2002

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (81K)

REFERENCES

  • 1
    Jemal A, Thomas A, Murray T, Thun M. Cancer statistics, 2002. CA Cancer J Clin. 2002; 52: 23–47.
    Direct Link:
  • 2
    Smith HO, Tiffany MF, Qualls CR, Key CR. The rising incidence of adenocarcinoma relative to squamous cell carcinoma of the uterine cervix in the United States—a 24-year population-based study. Gynecol Oncol. 2000; 78: 97–105.
  • 3
    Lea JS, Sheets EE, Wenham RM, et al. Stage IIB–IVB cervical adenocarcinoma: prognostic factors and survival. Gynecol Oncol. 2002; 84: 115–119.
  • 4
    Alfsen GC, Kristensen GB, Skovlund E, Pettersen EO, Abeler VM. Histologic subtype has minor importance for overall survival in patients with adenocarcinoma of the uterine cervix: a population-based study of prognostic factors in 505 patients with nonsquamous cell carcinomas of the cervix. Cancer. 2001; 92: 2471–2483.
    Direct Link:
  • 5
    Burke TW, Hoskins WJ, Heller PB, Bibro MC, Weiser EB, Park RC. Prognostic factors associated with radical hysterectomy failure. Gynecol Oncol. 1987; 26: 153–159.
  • 6
    Eifel PJ, Morris M, Oswald MJ, Wharton JT, Delclos L. Adenocarcinoma of the uterine cervix. Prognosis and patterns of failure in 367 cases. Cancer. 1990; 65: 2507–2514.
    Direct Link:
  • 7
    Eifel PJ, Burke TW, Morris M, Smith TL. Adenocarcinoma as an independent risk factor for disease recurrence in patients with Stage IB cervical carcinoma. Gynecol Oncol. 1995; 59: 38–44.
  • 8
    Kjorstad KE, Bond B. Stage IB adenocarcinoma of the cervix: metastatic potential and patterns of dissemination. Am J Obstet Gynecol. 1984; 150: 297–299.
  • 9
    Harrison TA, Sevin BU, Koechli O, et al. Adenosquamous carcinoma of the cervix: prognosis in early stage disease treated by radical hysterectomy. Gynecol Oncol. 1993; 50: 310–315.
  • 10
    Kjorstad KE. Adenocarcinoma of the uterine cervix. Gynecol Oncol. 1977; 5: 219–223.
  • 11
    Moberg PJ, Einhorn N, Silfversward C, Soderberg G. Adenocarcinoma of the uterine cervix. Cancer. 1986; 57: 407–410.
    Direct Link:
  • 12
    Gallup DG, Harper RH, Stock RJ. Poor prognosis in patients with adenosquamous cell carcinoma of the cervix. Obstet Gynecol. 1985; 65: 416–422.
  • 13
    Look KY, Brunetto VL, Clarke-Pearson DL, et al. An analysis of cell type in patients with surgically staged Stage IB carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol. 1996; 63: 304–311.
  • 14
    Hopkins MP, Schmidt RW, Roberts JA, Morley GW. The prognosis and treatment of Stage I adenocarcinoma of the cervix. Obstet Gynecol. 1988; 72: 915–921.
  • 15
    Goodman HM, Buttlar CA, Niloff JM, et al. Adenocarcinoma of the uterine cervix: prognostic factors and patterns of recurrence. Gynecol Oncol. 1989; 33: 241–247.
  • 16
    Saigo PE, Cain JM, Kim WS, Gaynor JJ, Johnson K, Lewis JL Jr. Prognostic factors in adenocarcinoma of the uterine cervix. Cancer. 1986; 57: 1584–1593.
    Direct Link:
  • 17
    Kleine W, Rau K, Schwoeorer D, Pfleiderer A. Prognosis of the adenocarcinoma of the cervix uteri: a comparative study. Gynecol Oncol. 1989; 35: 145–149.
  • 18
    Ishikawa H, Nakanishi T, Inoue T, Kuzuya K. Prognostic factors of adenocarcinoma of the uterine cervix. Gynecol Oncol. 1999; 73: 42–46.
  • 19
    Eifel PJ, Burke TW, Delclos L, Wharton JT, Oswald MJ. Early Stage I adenocarcinoma of the uterine cervix: treatment results in patients with tumors less than or equal to 4 cm in diameter. Gynecol Oncol. 1991; 41: 199–205.
  • 20
    Yazigi R, Sandstad J, Munoz AK, Choi DJ, Nguyen PD, Risser R. Adenosquamous carcinoma of the cervix: prognosis in Stage IB. Obstet Gynecol. 1990; 75: 1012–1015.
  • 21
    Kihana T, Tsuda H, Teshima S, et al. Prognostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix. Cancer. 1994; 73: 148–153.
    Direct Link:
  • 22
    Leung TW, Cheung AN, Cheng DK, Wong LC, Ngan HY. Expressions of c-erbB-2, epidermal growth factor receptor and pan-ras proto-oncogenes in adenocarcinoma of the cervix: correlation with clinical prognosis. Oncol Rep. 2001; 8: 1159–1164.
  • 23
    Mandai M, Konishi I, Koshiyama M, et al. Altered expression of nm23-H1 and c-erbB-2 proteins have prognostic significance in adenocarcinoma but not in squamous cell carcinoma of the uterine cervix. Cancer. 1995; 75: 2523–2529.
    Direct Link:
View Full Article (HTML) Get PDF (81K)