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Laparoscopic sentinel lymph node procedure using a combination of patent blue and radioisotope in women with cervical carcinoma†

  1. Emmanuel Barranger M.D.1,‡,*,
  2. Dany Grahek M.D.2,
  3. Annie Cortez M.D.3,
  4. Jean Noel Talbot M.D.2,
  5. Serge Uzan M.D.1,
  6. Emile Darai M.D., Ph.D.1

Article first published online: 29 MAY 2003

DOI: 10.1002/cncr.11423

Issue

Cancer

Cancer

Volume 97, Issue 12, pages 3003–3009, 15 June 2003

Additional Information

How to Cite

Barranger, E., Grahek, D., Cortez, A., Talbot, J. N., Uzan, S. and Darai, E. (2003), Laparoscopic sentinel lymph node procedure using a combination of patent blue and radioisotope in women with cervical carcinoma. Cancer, 97: 3003–3009. doi: 10.1002/cncr.11423

Author Information

  1. 1

    Department of Gynecology and Obstetrics, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Paris, France

  2. 2

    Department of Nuclear Medicine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Paris, France

  3. 3

    Department of Pathology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Paris, France

  1. ‡

    Fax: (011) 33 156016042

*Service de Gynécologie-Obstétrique, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France

  1. †

    See editorial on pages 2945–7, this issue.

Publication History

  1. Issue published online: 29 MAY 2003
  2. Article first published online: 29 MAY 2003
  3. Manuscript Accepted: 30 DEC 2002
  4. Manuscript Revised: 20 DEC 2002
  5. Manuscript Received: 8 NOV 2002

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Keywords:

  • sentinel lymph node biopsy;
  • laparoscopy;
  • patent blue;
  • radiocolloid;
  • cervical carcinoma

The authors demonstrated the feasibility of a laparoscopic sentinel lymph node procedure based on combined detection with patent blue and radiocolloid in patients with carcinoma of the uterine cervix.

See also pages 2945–7.

Abstract

BACKGROUND

The authors evaluated the feasibility of a laparoscopic sentinel lymph node (SN) procedure with combined radioisotopic and patent blue labeling in patients with cervical carcinoma.

METHODS

Thirteen women (median age, 52.5 years) with cervical carcinoma (Stage Ia2 in 1 patient, Stage Ib1 in 10 patients, Stage Ib2 in 1 patient, and Stage IIa in 1 patient) underwent a laparoscopic SN procedure using an endoscopic γ probe after both radioactive isotope and patent blue injections. After the procedure, all patients underwent complete laparoscopic pelvic lymphadenectomy and either laparoscopic radical hysterectomy (eight patients) or the Schauta–Amreich operation (five patients).

RESULTS

SNs (mean, 1.7 SNs per patient; range, 1–3 SNs per patient) were identified in 12 of 13 patients. A median of 10.5 pelvic lymph nodes per patient (range, 4–17 pelvic lymph nodes per patient) were removed. No lymph node involvement was detected in SNs with hematoxylin and eosin staining. Immunohistochemical studies identified four metastatic SNs in two patients, with micrometastases in two SNs from the first patient and isolated tumor cells in two SNs from the second patient. No false-negative SN results were obtained.

CONCLUSIONS

The results of this study suggest that SN detection with a combination of radiocolloid and patent blue is feasible in patients with cervical carcinoma. The combination of laparoscopy and the SN procedure permitted minimally invasive management of early-stage disease. Cancer 2003;97:3003–9. © 2003 American Cancer Society.

DOI 10.1002/cncr.11423

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