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Androgen receptors frequently are expressed in breast carcinomas
Potential relevance to new therapeutic strategies
Article first published online: 25 JUN 2003
DOI: 10.1002/cncr.11532
Copyright © 2003 American Cancer Society
Additional Information
How to Cite
Moinfar, F., Okcu, M., Tsybrovskyy, O., Regitnig, P., Lax, S. F., Weybora, W., Ratschek, M., Tavassoli, F. A. and Denk, H. (2003), Androgen receptors frequently are expressed in breast carcinomas. Cancer, 98: 703–711. doi: 10.1002/cncr.11532
Publication History
- Issue published online: 1 AUG 2003
- Article first published online: 25 JUN 2003
- Manuscript Accepted: 17 APR 2003
- Manuscript Revised: 30 JAN 2003
- Manuscript Received: 11 NOV 2002
REFERENCES
- 1, , . Estrogen and progesterone receptors in the prediction of response of breast cancer to endocrine therapy. Cancer. 1980; 46: 2838–2841.Direct Link:
- 2, , . The clinical value of multiple steroid receptor assays in breast cancer management. Cancer. 1980; 46: 2939–2945.Direct Link:
- 3, , , . Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res. 1977; 37: 4669–4671.
- 4, , . Prognostic value of estrogen receptors in primary breast cancer. Cancer. 1979; 44: 671–675.Direct Link:
- 5, , , et al. Prognostic value of estrogen and progesterone receptors in operable breast cancer. Results of a univariate and multivariate analysis. Cancer. 1988; 62: 2517–2524.Direct Link:
- 6, , . Estrogen receptors and breast cancer. Epidemiol Rev. 1986; 8: 42–59.
- 7
- 8. Steroid-hormone receptors in breast cancer. Cancer. 1984; 53: 630–643.Direct Link:
- 9, . Role of progesterone receptors in breast cancer. Semin Oncol. 1985; 12: 12–16.
- 10, , , , , . Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987; 235: 177–182.
- 11, , , et al. The prognostic value of c-erbB2 in primary breast carcinomas: a study on 942 cases. Breast Cancer Res Treat. 1995; 35: 283–291.
- 12, , , et al. Assessment of HER-2/neu status in breast cancer. Automated Cellular Imaging System (ACIS)-assisted quantitation of immunohistochemical assay achieves high accuracy in comparison with fluorescence in situ hybridization assay as the standard. Am J Clin Pathol. 2001; 116: 495–503.
- 13, , , et al. HER-2 amplification, steroid receptors and epidermal growth factor receptor in primary breast cancer. Oncogene. 1989; 4: 109–114.
- 14, , , , , . The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast. Oncogene. 1992; 7: 1027–1032.
- 15, , , , . Critical determination of the frequency of c-erbB-2 amplification in breast cancer. Br J Cancer. 1994; 70: 434–439.
- 16, . HER-2/neu (c-erb-B2) gene and protein in breast cancer. Am J Clin Pathol. 1999; 112(1 Suppl 1 ): S53–S67.
- 17, , , et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2002; 20: 719–726.
- 18, , . Oestrogen and androgen receptors in breast cancer and response to endocrine therapy. Br Med J. 1975; 4: 503.
- 19, . A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay. Cancer. 1976; 38: 868–874.Direct Link:
- 20, , , , , . Androgen receptors in breast cancer. Cancer. 1984; 54: 2436–2440.Direct Link:
- 21, , , , . Androgen receptor (AR) expression in normal and cancerous human endometrial tissues detected by RT-PCR and immunohistochemistry. Anticancer Res. 2002; 22: 1025–1031.
- 22, . Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991; 19: 403–410.Direct Link:
- 23. Pathology of the breast. Stamford, CT: Appleton & Lange, 1998.
- 24. Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia. Mod Pathol. 1998; 11: 140–154.
- 25SPSS. Professional statistics. Version 6.1. Chicago: SPSS Inc., 1993.
- 26SPSS. Categorical principal component analysis (CATPCA). Chicago: SPSS Inc., 1999.
- 27, , . The effects of androgens and antiandrogens on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 1976; 36: 4610–4618.
- 28
- 29, , , . Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestogen receptor activity. Eur J Cancer Clin Oncol. 1985; 21: 539–542.
- 30, , . Improved measurement of androgen receptors in human breast cancer. Cancer Res. 1989; 49: 7162–7167.
- 31. Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ. Pathol Res Pract. 1997; 193: 753–758.
- 32, , , et al. Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. Hum Pathol. 2001; 32: 487–493.
- 33, , . Androgen receptor expression in ductal carcinoma in situ of the breast: relation to oestrogen and progesterone receptors. J Clin Pathol. 2002; 55: 14–16.
- 34, , , , . Relation between apocrine differentiation and receptor status, prognosis and hormonal response in breast cancer. Eur J Cancer. 1990; 26: 1145–1147.
- 35. Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors. J Pathol. 1993; 170: 31–35.Direct Link:
- 36, . Effects of steroids on growth of an androgen-dependent mouse mammary carcinoma in cell culture. Exp Cell Res. 1972; 73: 351–359.
- 37, , . Mediation by the androgen receptor of the stimulatory and antiandrogenic actions of 17 beta-estradiol on the growth of androgen-sensitive Shionogi mammary carcinoma cells in culture. Endocrinology. 1988; 123: 1418–1424.
- 38AMA Committee on Research. Androgens and estrogens in the treatment of disseminated mammary carcinoma. J Am Med Assoc. 1960; 172: 1271–1274.
- 39, , , , , Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma. J Natl Cancer Inst. 1983; 70: 69–74.
- 40, , , . Metabolism of androgens by human breast tissue. Lancet. 1973; 1: 912–913.
- 41, . Aromatization of androgens by human abdominal and breast fat tissue. J Clin Endocrinol Metab. 1975; 40: 367–372.
- 42. Overview of the pharmacology of the aromatase inactivator exemestane. Breast Cancer Res Treat. 2002; 74: 177–185.
- 43, , , et al. American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for women with hormone receptor-positive breast cancer: status report 2002. J Clin Oncol. 2002; 20: 3317–3327.
- 44, . Recent advances in aromatase inhibitor therapy for breast cancer. Semin Oncol. 2002; 29 ( 3 Suppl 11 ): 120–128.

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