1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470 "Cancer")
Fax: (206) 685-9651
1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
Original Article
You have full text access to this OnlineOpen article
Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma–pancreatic carcinoma syndrome
Article first published online: 13 JUN 2003
DOI: 10.1002/cncr.11562
Copyright © 2003 American Cancer Society
Additional Information
How to Cite
Rulyak, S. J., Brentnall, T. A., Lynch, H. T. and Austin, M. A. (2003), Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma–pancreatic carcinoma syndrome. Cancer, 98: 798–804. doi: 10.1002/cncr.11562
Publication History
- Issue published online: 1 AUG 2003
- Article first published online: 13 JUN 2003
- Manuscript Revised: 7 MAY 2003
- Manuscript Accepted: 7 MAY 2003
- Manuscript Received: 13 DEC 2002
Funded by
- National Institutes of Health. Grant Number: DK07742
- University Initiatives Fund of the University of Washington
- National Cancer Institute. Grant Number: U24 CA78164
REFERENCES
- 1, , , . Cancer statistics, 2002. CA Cancer J Clin. 2002; 52: 23–47.Direct Link:
- 2, , , et al. Familial pancreatic cancer: a review. Semin Oncol. 1996; 23: 251–255.
- 3, . Inherited pancreatic cancer: surveillance and treatment strategies for affected families. Pancreatology. 2001; 1: 477–485.
- 4, , , , . Pancreatic carcinoma and hereditary nonpolyposis colorectal cancer: a family study. Br J Cancer. 1985; 52: 27.
- 5, , , et al. Germline BRCA2 617delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nat Genet. 1997; 16: 17–18.
- 6, , , et al. Increased risk of cancer in the Peutz–Jeghers syndrome. N Engl J Med. 1987; 316: 1511–1514.
- 7, , , et al. Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut. 1993; 34: 1394–1396.
- 8, , , , . Familial atypical multiple-mole melanoma syndrome: segregation analysis. J Med Genet. 1983; 20: 342–344.
- 9, , , et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med. 1995; 333: 970–974.
- 10, , , , , . Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden). Int J Cancer. 2000; 87: 809–811.Direct Link:
- 11, , , et al. High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families. J Natl Cancer Inst. 2000; 92: 1260–1266.
- 12, . Screening for CDKN2A mutations in hereditary melanoma. J Natl Cancer Inst. 1997; 89: 676–678.
- 13, , , et al. CDKN2A germline mutations in familial pancreatic cancer. Ann Surg. 2002; 236: 730–737.
- 14, , , et al. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst. 1997; 89: 442–446.
- 15, , , et al. The risk of cancer among patients with cystic fibrosis. Cystic Fibrosis and Cancer Study Group. N Engl J Med. 1995; 332: 494–499.
- 16, , , et al. A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genet. 2002; 70: 1044–1048.
- 17, , , , . Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations. J Natl Cancer Inst. 2000; 92: 1006–1010.
- 18, . Hereditary and malignant melanoma: implications for early cancer detection. Can Med Assoc J. 1968; 99: 17–21.
- 19, , , et al. Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. Cancer. 2002; 94: 84–96.Direct Link:
- 20, , . Fundamentals of genetic epidemiology. Monographs in epidemiology and biostatistics, Volume 22. New York: Oxford University Press, 1993.
- 21, , , et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science. 1994; 264: 436–440.
- 22, , , et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet. 1994; 8: 27–32.
- 23, , , et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997; 57: 3126–3130.
- 24, , , et al. CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. Am J Pathol. 1998; 153: 159–163.
- 25, , , . Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds. Gastroenterology. 2003; 124: 1292–1299.