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Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy†

The National Cancer Institute randomized trial

  1. Matthew M. Poggi M.D.1,‡,*,
  2. David N. Danforth M.D.2,
  3. Linda C. Sciuto B.S.N.1,
  4. Sharon L. Smith M.S.1,
  5. Seth M. Steinberg Ph.D.3,
  6. David J. Liewehr M.S.3,
  7. Cynthia Menard M.D.1,
  8. Marc E. Lippman M.D.4,
  9. Allen S. Lichter M.D.5,
  10. Rosemary M. Altemus M.D., Ph.D.1

Article first published online: 14 JUL 2003

DOI: 10.1002/cncr.11580

Issue

Cancer

Cancer

Volume 98, Issue 4, pages 697–702, 15 August 2003

Additional Information

How to Cite

Poggi, M. M., Danforth, D. N., Sciuto, L. C., Smith, S. L., Steinberg, S. M., Liewehr, D. J., Menard, C., Lippman, M. E., Lichter, A. S. and Altemus, R. M. (2003), Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy. Cancer, 98: 697–702. doi: 10.1002/cncr.11580

Author Information

  1. 1

    Radiation Oncology Branch, National Cancer Institute, Bethesda Maryland

  2. 2

    Surgery Branch, National Cancer Institute, Bethesda, Maryland

  3. 3

    Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland

  4. 4

    Department of Internal Medicine, University Of Michigan Medical School, Ann Arbor, Michigan

  5. 5

    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan

  1. ‡

    Fax: (301) 295-5788

*5412 30th Place, NW, Washington, DC 20015

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

Publication History

  1. Issue published online: 1 AUG 2003
  2. Article first published online: 14 JUL 2003
  3. Manuscript Accepted: 14 MAY 2003
  4. Manuscript Revised: 1 MAY 2003
  5. Manuscript Received: 1 APR 2003

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Keywords:

  • breast carcinoma;
  • conservation;
  • radiation therapy;
  • mastectomy

Abstract

BACKGROUND

Between 1979–1987, the National Cancer Institute conducted a randomized, prospective study of mastectomy (MT) versus breast conservation therapy (BCT) in the treatment of patients with early-stage breast carcinoma. After a median potential follow-up of 18.4 years, the authors present the updated results.

METHODS

After informed consent was obtained from each patient, 237 evaluable women with clinical AJCC Stage I and Stage II breast carcinoma were enrolled on an institutionally reviewed protocol and randomly assigned to undergo modified radical MT (116 patients) or BCT (121 patients), which was comprised of lumpectomy, axillary lymph node dissection, and radiation therapy. Negative surgical margins in the lumpectomy arm were not required. The 237 randomized patients were followed for a median potential follow-up of 18.4 years. The primary endpoints were overall survival and disease-free survival.

RESULTS

At a median follow-up of 18.4 years, there was no detectable difference with regard to overall survival between patients treated with MT and those treated with BCT (58% vs. 54%; P = 0.67 overall). Twenty-seven women in the BCT arm (22%) experienced an in-breast event. After censoring in-breast events in the BCT arm that were salvaged successfully by MT, disease-free survival also was found to be statistically similar (67% in the MT arm vs. 63% in the BCT arm; P = 0.64 overall). There was no statistically significant difference with regard to contralateral breast carcinoma between the two treatment arms (P = 0.70).

CONCLUSIONS

After nearly 20 years of follow-up, there was no detectable difference in overall survival or disease-free survival in patients with early-stage breast carcinoma who were treated with MT compared with those treated with BCT. For BCT patients, long-term in-breast failures continued to occur throughout the duration of follow-up. There was no statistically significant difference in the incidence of contralateral breast carcinoma between the two treatment groups. Cancer 2003;98:697–702. Published 2003 by the American Cancer Society.

DOI 10.1002/cncr.11580

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