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Innovations in the treatment of invasive cervical cancer

  1. Frederick B. Stehman M.D.1,†,*,
  2. Peter G. Rose M.D.2,
  3. Benjamin E. Greer M.D.3,
  4. Michel Roy M.D.4,
  5. Marie Plante M.D.4,
  6. Manuel Penalver M.D.5,
  7. Anuja Jhingran M.D.6,
  8. Patricia Eifel M.D.6,
  9. Fredrick Montz M.D.7,8,9,‡,
  10. J. Taylor Wharton M.D.10

Article first published online: 22 OCT 2003

DOI: 10.1002/cncr.11676

Issue

Cancer

Cancer

Special Issue: Proceedings of the Second International Conference on Cervical Cancer

Supplement: Second International Conference on Cervical Cancer

Volume 98, Issue Supplement S9, pages 2052–2063, 1 November 2003

Additional Information

How to Cite

Stehman, F. B., Rose, P. G., Greer, B. E., Roy, M., Plante, M., Penalver, M., Jhingran, A., Eifel, P., Montz, F. and Wharton, J. T. (2003), Innovations in the treatment of invasive cervical cancer. Cancer, 98: 2052–2063. doi: 10.1002/cncr.11676

Author Information

  1. 1

    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana

  2. 2

    Department of Gynecologic Oncology, MetroHealth Medical Center, Cleveland, Ohio

  3. 3

    Department of Gynecologic Oncology, University of Washington School of Medicine, Seattle, Washington

  4. 4

    Department of Obstetrics and Gynecology, Laval University, Quebec City, Quebec, Canada

  5. 5

    Department of Gynecologic Oncology, University of Miami School of Medicine, Miami, Florida

  6. 6

    Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  7. 7

    Department of Gynecology and Obstetrics, The Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland

  8. 8

    Department of Surgery, The Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland

  9. 9

    Department of Oncology, The Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland

  10. 10

    Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  1. †

    Fax: (317) 274-7417

  2. ‡

    Deceased.

*Department of Obstetrics and Gynecology, Indiana University School of Medicine, 550 North University Boulevard, Room 2440, Indianapolis, IN 46202-5274

Publication History

  1. Issue published online: 22 OCT 2003
  2. Article first published online: 22 OCT 2003
  3. Manuscript Accepted: 21 JAN 2003
  4. Manuscript Received: 31 OCT 2002

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Abstract

Invasive cervical cancer is characterized by basement membrane–invading lesions capable of metastasizing through the lymphatic and vascular systems. Treatment methods were reviewed by panelists at the Second International Conference on Cervical Cancer (Houston, TX, April 11–14, 2002), and new opportunities for translational research were discussed. Reviews encompassed hysterectomy with or without lymph node dissection or cervical conization in cases with microinvasion and radical trachelectomy with or without lymph node dissection as fertility-sparing surgery. Chemoradiation is used to treat advanced cervical malignancies, and the risks and benefits of radiotherapy are significant. Pelvic exenteration is used to treat certain types of recurrences. Use of the Miami pouch for continent urinary diversion was highlighted. Gynecologic oncologists expect novel in vivo imaging techniques currently being developed to help guide therapy choices within the next decade. The most significant research priorities are large group-randomized trials involving fertility-sparing procedures and the management of microinvasive carcinoma (MICA); better identification of candidates for chemoradiation; and the development of innovative approaches to exenteration. Improving diagnostic technologies, refining the criteria by which therapies are chosen, and preserving fertility remain challenges in selecting the most appropriate treatment for invasive cervical cancer. Research advances in both diagnosis and treatment are expected to improve therapy and outcomes. Cancer 2003;98(9 Suppl): 2052–2063. © 2003 American Cancer Society.

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