You have full text access to this OnlineOpen article

Innovations in the treatment of invasive cervical cancer

  1. Frederick B. Stehman M.D.1,†,*,
  2. Peter G. Rose M.D.2,
  3. Benjamin E. Greer M.D.3,
  4. Michel Roy M.D.4,
  5. Marie Plante M.D.4,
  6. Manuel Penalver M.D.5,
  7. Anuja Jhingran M.D.6,
  8. Patricia Eifel M.D.6,
  9. Fredrick Montz M.D.7,8,9,‡,
  10. J. Taylor Wharton M.D.10

Article first published online: 22 OCT 2003

DOI: 10.1002/cncr.11676

Issue

Cancer

Cancer

Special Issue: Proceedings of the Second International Conference on Cervical Cancer

Supplement: Second International Conference on Cervical Cancer

Volume 98, Issue Supplement S9, pages 2052–2063, 1 November 2003

Additional Information

How to Cite

Stehman, F. B., Rose, P. G., Greer, B. E., Roy, M., Plante, M., Penalver, M., Jhingran, A., Eifel, P., Montz, F. and Wharton, J. T. (2003), Innovations in the treatment of invasive cervical cancer. Cancer, 98: 2052–2063. doi: 10.1002/cncr.11676

Author Information

  1. 1

    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana

  2. 2

    Department of Gynecologic Oncology, MetroHealth Medical Center, Cleveland, Ohio

  3. 3

    Department of Gynecologic Oncology, University of Washington School of Medicine, Seattle, Washington

  4. 4

    Department of Obstetrics and Gynecology, Laval University, Quebec City, Quebec, Canada

  5. 5

    Department of Gynecologic Oncology, University of Miami School of Medicine, Miami, Florida

  6. 6

    Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  7. 7

    Department of Gynecology and Obstetrics, The Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland

  8. 8

    Department of Surgery, The Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland

  9. 9

    Department of Oncology, The Johns Hopkins Hospital and Medical Institutions, Baltimore, Maryland

  10. 10

    Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  1. †

    Fax: (317) 274-7417

  2. ‡

    Deceased.

*Department of Obstetrics and Gynecology, Indiana University School of Medicine, 550 North University Boulevard, Room 2440, Indianapolis, IN 46202-5274

Publication History

  1. Issue published online: 22 OCT 2003
  2. Article first published online: 22 OCT 2003
  3. Manuscript Accepted: 21 JAN 2003
  4. Manuscript Received: 31 OCT 2002

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (206K)

REFERENCES

  • 1
    Benedet JL, Odicino F, Maisonneuve P, et al. Carcinoma of the cervix uteri. J Epidemiol Biostat. 2001; 6: 7–43.
  • 2
    SobinLH, WittekindC, editors. TNM classification of malignant tumours, 6th edition. New York: John Wiley & Sons, 2002.
  • 3
    Mestwerdt G. Probeexzision und kolposkopie in de fruehdiagnose des portiokarzinoms. [Probe excision and colposcopy in the early diagnosis of cervix cancer]. Zentralbl Gynaekol. 1947; 4: 326–332.
  • 4
    Welsh A, Nicolaides K. Cervical screening for preterm delivery. Curr Opin Obstet Gynecol. 2002; 14: 195–202.
  • 5
    Leitich H, Brunbauer M, Kaider A, Egarter C, Husslein P. Cervical length and dilatation of the internal cervical os detected by vaginal ultrasonography as markers for preterm delivery: a systematic review. Am J Obstet Gynecol. 1999; 181: 1465–1472.
  • 6
    Antsakila A, Saskalakis G, Papageorgiou I, Aravantinos D. Conservative treatment after miscarriage of one fetus in multifetal pregnancies. Report of three cases and review of the literature. Fetal Diagn Ther. 1996; 11: 366–372.
  • 7
    Dargent D, Mathevet P. [Radical laparoscopic vaginal hysterectomy]. J Gynecol Obstet Biol Reprod (Paris). 1992; 21: 709–710.
  • 8
    Dargent D. Radical trachelectomy: an operation that preserves the fertility of young women with invasive cervical cancer. Bull Acad Natl Med. 2001; 185: 1295–1304.
  • 9
    Covens A, Shaw P, Murphy J, et al. Is radical trachelectomy a sage alternative to radical hysterectomy for patients with Stage IA–B carcinoma of the cervix? Cancer. 1999; 86: 2273–2279.
    Direct Link:
  • 10
    Roy M, Plante M. [Radical vaginal trachelectomy for invasive cervical cancer]. J Gynecol Obstet Biol Reprod (Paris). 2000; 29: 279–281.
  • 11
    Shepherd JH, Mould T, Oram DH. Radical trachelectomy in early stage carcinoma of the cervix: outcome as judged by recurrence and fertility rates. BJOG. 2001; 108: 882–885.
  • 12
    Whitney CW, Sause W, Bundy BN, et al. A randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in Stages IIB–IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol. 1999; 17: 1339–1348.
  • 13
    Peters WA III, Liu PY, Barrent RJ II, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol. 2000; 18: 1606–1613.
  • 14
    Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 1999; 340: 1144–1153.
  • 15
    Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med. 1999; 340: 1137–1143.
  • 16
    Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky Stage IB cervical carcinoma. N Engl J Med. 1999; 340: 1154–1161.
  • 17
    National Cancer Institute. Q & A:concurrent chemotherapy and radiation for cervical cancer [monograph online]. Available from URL: http://www.nci.nih.gov/clinicaltrials/developments/qa-chemo-and-radiation0600 [accessed June 30, 2002].
  • 18
    Flam M, John M, Pajak TF. Role of mitomycin in combination with fluoruracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a Phase III randomized intergroup study. J Clin Oncol. 1996; 14: 2527–2539.
  • 19
    Thomas GM. Concurrrent chemotherapy and radiation for locally advanced cervical cancer: the new standard of care. Semin Radiat Oncol. 2000; 10: 44–50.
  • 20
    Corn BW, Micaily B, Dunton CJ, et al. Concomitant irradiation and dose-escalating carboplatin for locally advanced carcinoma of the uterine cervix: an updated report. Am J Clin Oncol. 1998; 21: 31–35.
  • 21
    Micheletti E, La Face B, Bianchi E, et al. Continuous infusion of carboplatin during conventional radiotherapy treatment in advanced squamous carcinoma of the cervix uteri IIB-IIIB (UICC). A Phase I/II and pharmacokinetic study. Am J Clin Oncol. 1997; 20: 613–620.
  • 22
    Tsuda H, Yamamoto K, Kawabata M, Lee T, Hidaka A. Continuous local injection of carboplatin into the uterine cervix for cervical and endometrial cancer: preliminary study. Gynecol Obstet Invest. 1997; 44: 196–199.
  • 23
    Muderspach LI, Curtin JP, Roman LE, et al. Carboplatin as a radiation sensitizer in locally advanced cervical cancer: a pilot study. Gynecol Oncol. 1997; 65: 336–342.
  • 24
    McGuire WP, Blessing JA, Moore D, Lentz SS, Photopulos G. Paclitaxel has moderate activity in squamous cervix cancer. A Gynecologic Oncology Group study. J Clin Oncol. 1996; 14: 792–795.
  • 25
    Schilder RJ, Blessing JA, Morgan M, Mangan CE, Rader JS. Evaluation of gemcitabine in patients with squamous cell carcinoma of the cervix: a Phase II study of the Gynecologic Oncology Group. Gynecol Oncol. 2000; 76: 204–207.
  • 26
    Muderspach LI, Blessing JA, Levenback C, Moore JL Jr. A Phase II study of topotecan in patients with squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol. 2001; 81: 213–215.
  • 27
    Lhomme C, Vermorken JB, Mickiewicz E, et al. Phase II trial of vinorelbine in patients with advanced and/or recurrent cervical carcinoma: an EORTC Gynaecological Cancer Cooperative Group Study. Eur J Cancer. 2000; 36: 194–199.
  • 28
    Rose PG, Blessing JA, Gersehnson DM, McGehee R. Paclitaxel and cisplatin as first-line therapy in recurrent or advanced squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. J Clin Oncol. 1999; 17: 2676–2680.
  • 29
    Papadimitriou CA, Sarris K, Moulopoulos LA, et al. Phase II trial of paclitaxel and cisplatin in metastatic and recurrent carcinoma of the uterine cervix. J Clin Oncol. 1999; 17: 761–766.
  • 30
    Duenas-Gonzlaez A, Lopez-Graniel C, Gonzalez A, et al. A Phase II study of gemcitabine and cisplatin combination as induction chemotherapy for untreated locally advanced cervical carcinoma. Ann Oncol. 2001; 12: 541–547.
  • 31
    Duenas-Gonzlaez A, Hinojosa-Garcia LM, Lopez-Graniel C, Melendez-Zagla J, Maldonado V, de la Guerra J. Weekly cisplatin/low-dose gemcitabine combination for advanced and recurrent cervical carcinoma. Am J Clin Oncol. 2001; 24: 201–203.
  • 32
    Burnett AF, Roman LD, Garcia AA, Muderspach LI, Brader KR, Morrow CP. A Phase II study of gemcitabine and cisplatin in patients with advanced, persistent, or recurrent squamous cell carcinoma of the cervix. Gynecol Oncol. 2000; 76: 63–66.
  • 33
    Fiorica J, Holloway R, Ndubisi B, et al. Phase II trial of topotecan and cisplatin in persistent or recurrent squamous and nonsquamous carcinomas of the cervix. Gynecol Oncol. 2002; 85: 89–94.
  • 34
    Bookman MA, Blessing JA, Hanjani P, Herzog TJ, Andersen WA. Topotecan in squamous cell carcinoma of the cervix: a Phase II study of the Gynecologic Oncology Group. Gynecol Oncol. 2000; 77: 446–449.
  • 35
    Mastroianni M, Di Bano G, Melilli GA, et al. [Combination of cisplatin and vinorelbine in the neoadjuvant treatment of locally advanced cervical carcinoma. Phase II study]. Minerva Ginecol. 2000; 52: 95–98.
  • 36
    Pignata S, Silverstro G, Ferrari E, et al. Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. J Clin Oncol. 1999; 17: 756–760.
  • 37
    Mourtardier V, Christophe M, Lelong B, Houvenaeghel F, Delpero JR. Iliac atherosclerotic occlusive disease complicating radiation therapy for cervix cancer: a case series. Gynecol Oncol. 2002; 84: 456–459.
  • 38
    Kleinerman RA, Boice JD Jr., Storm HH, et al. Second primary cancer after treatment for cervical cancer: an international cancer registries study. Cancer. 1995; 76: 442–452.
    Direct Link:
  • 39
    Wolfson AH. Conventional radiation therapy of cervical cancer. Semin Surg Oncol. 1999; 16: 242–246.
    Direct Link:
  • 40
    Denton AS, Bond SJ, Matthews S, Bentzen SM, Maher EJ. National audit of the managements and outcome of carcinoma of the cervix treated with radiotherapy in 1993. Clin Oncol (R Coll Radiol). 2000; 12: 347–353.
  • 41
    Penalver MA, Bejany D, Averette HE, Donato D, Sevin BU, Suarez J. Continent urimary diversion in gynecologic oncology. Gynecol Oncol. 1989; 34: 247–288.
  • 42
    Penalver AM, Angioli R, Mirhashemi R, Malik R. Management of early and late complications of ileocolonic continent urinary reservoir (Miami pouch). Gynecol Oncol. 1998; 69: 185–191.
  • 43
    Angioli R, Estape R, Canuaria G, et al. Urinary complications of Miami pouch: trend of conservative management. Am J Obstet Gynecol. 1998; 179: 343–348.
  • 44
    Cosin JA, Fowler JM, Chen MD, et al. Pretreatment surgical staging in patients with cervical cancer: the case for lymph node debulking. Cancer. 1998; 82: 2241–2248.
    Direct Link:
  • 45
    Goff BA, Muntz HG, Paley PJ, Tamimi HK, Koh WJ, Greer BE. Impact of surgical staging in women with locally advanced cervical cancer. Gynecol Oncol. 1999; 74: 436–442.
  • 46
    Greer BE, Koh WJ, Goff BA, Stelzer KJ, Comsia N, Tran A. Expanding customized pelvic radiotherapy fields for treatment of locally-regionally advanced carcinomas of the cervix: outcome, complications, and future strategies. Am J Obstet Gynecol. 1996; 174: 1141–1150.
  • 47
    Grigsby PW, Siegel BA, Dehdashti F. Lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol. 2001; 17: 3745–3749.
  • 48
    Benedet J, Odicino F, Maisonneuve P, et al. Carcinoma of the cervix uteri. Annual report on the results of treatment in gynecological cancer. J Epidemiol Biostat. 1998; 3: 5–34.
View Full Article (HTML) Get PDF (206K)