You have full text access to this OnlineOpen article

Optical imaging of the cervix

  1. Rebekah A. Drezek Ph.D.1,
  2. Rebecca Richards-Kortum Ph.D.2,
  3. Molly A. Brewer D.V.M., M.D., M.S.3,
  4. Michael S. Feld Ph.D.4,
  5. Constantinos Pitris Ph.D.5,
  6. Alex Ferenczy M.D.6,†,
  7. Mark L. Faupel Ph.D.7,‡,
  8. Michele Follen M.D., Ph.D.8,§,*

Article first published online: 22 OCT 2003

DOI: 10.1002/cncr.11678

Issue

Cancer

Cancer

Special Issue: Proceedings of the Second International Conference on Cervical Cancer

Supplement: Second International Conference on Cervical Cancer

Volume 98, Issue Supplement S9, pages 2015–2027, 1 November 2003

Additional Information

How to Cite

Drezek, R. A., Richards-Kortum, R., Brewer, M. A., Feld, M. S., Pitris, C., Ferenczy, A., Faupel, M. L. and Follen, M. (2003), Optical imaging of the cervix. Cancer, 98: 2015–2027. doi: 10.1002/cncr.11678

Author Information

  1. 1

    Bioengineering Department, Rice University, Houston, Texas

  2. 2

    Department of Biomedical Engineering, The University of Texas, Austin, Texas

  3. 3

    Gynecologic Oncology, Arizona Cancer Center, Arizona Health Science Center, Tucson, Arizona

  4. 4

    George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts

  5. 5

    Wellman Laboratory, Massachusetts General Hospital, Boston, Massachusetts

  6. 6

    Department of Pathology, McGill University, The Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada

  7. 7

    SpectRx, Inc., Norcross, Virginia

  8. 8

    Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  1. †

    Dr. Alex Ferenczy is a clinical advisor for LifeSpex, Inc.

  2. ‡

    Dr. Mark L. Faupel is an employee of SpectRx, Inc.

  3. §

    Fax: (713) 792-4856

*Center for Biomedical Engineering, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 193, Houston, TX 77030

Publication History

  1. Issue published online: 22 OCT 2003
  2. Article first published online: 22 OCT 2003
  3. Manuscript Accepted: 29 APR 2003
  4. Manuscript Revised: 25 APR 2003
  5. Manuscript Received: 31 OCT 2002

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (424K)

REFERENCES

  • 1
    Fahey MT, Irwig L, Macaskill P. Meta-analysis of Pap test accuracy. Am J Epidemiol. 1995; 141: 680–689.
  • 2
    Duke University. Evaluation of cervical cytology. Evidence Report/Technology Assessment No. 5. Rockville, MD: U.S. Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, 1999.
  • 3
    Nanda K, McCrory DC, Myers ER, et al. Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Ann Intern Med. 2000; 132: 810–819.
  • 4
    Mitchell MF, Schottenfeld D, Tortolero-Luna G, Cantor SB, Richards-Kortum R. Colposcopy for the diagnosis of intraepithelial lesions: a meta-analysis. Obstet Gynecol. 1998; 91: 626–631.
  • 5
    Belinson JL, Pretorius RG, Zhang WH, Wu LY, Qiao YL, Elson P. Cervical cancer screening by simple visual inspection after acetic acid. Obstet Gynecol. 2001; 98: 441–444.
  • 6
    Benedet JL, Andersen GH, Matsic JP, Miller DM. A quality-control program for colposcopic practice. Obstet Gynecol. 1991; 78: 872–875.
  • 7
    Wright TC Jr., Cox JT, Massad LS, Twiggs LB, Wilkinson EJ; ASCCP-Sponsored Consensus Conference. 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities. JAMA. 2002; 287: 2120–2129.
  • 8
    Littenberg B. Technology assessment in medicine. Acad Med. 1992; 67: 424–428.
  • 9
    Wortman PM, Saxe L. Appendix C: assessment of medical technology: methodological considerations. In: Strategies for medical technology assessment. Washington, DC: Office of Technology Assessment, 1982: 127–149.
  • 10
    Richards-Kortum R, Sevick-Muraca E. Quantitative optical spectroscopy for tissue diagnosis. Annu Rev Phys Chem. 1996; 47: 555–606.
  • 11
    Wagnieres GA, Star WM, Wilson BC. In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem Photobiol. 1998; 68: 603–632.
  • 12
    Ramanujam N. Fluorescence spectroscopy of neoplastic and non-neoplastic tissues. Neoplasia. 2000; 2: 89–117.
  • 13
    Stryer L. Biochemistry, 34th edition. New York: W.H. Freeman, 1988.
  • 14
    Lakowicz JR. Principles of fluorescence spectroscopy. New York: Plenum Press, 1985.
  • 15
    Masters BR, Chance B. Redox confocal imaging: intrinsic fluorescent probes of cellular metabolism. In: MasonWT, editor. Fluorescent and luminescent probes for biological activity. London: Academic Press, 1993: 44–57.
  • 16
    Ramanujam N, Mitchell MF, Mahadevan A, et al. In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence. Proc Natl Acad Sci USA. 1994; 91: 10193–10197.
  • 17
    Schomacker KT, Frisoli JK, Compton CC, et al. Ultraviolet laser-induced fluorescence of colonic tissue: basic biology and diagnostic potential. Lasers Surg Med. 1992; 12: 63–78.
    Direct Link:
  • 18
    Fujimoto D. Isolation and characterization of a fluorescent material in bovine achilles tendon collagen. Biochem Biophys Res Commun. 1977; 76: 1124–1129.
  • 19
    Blomfield J, Farrar JF. The fluorescent properties of maturing arterial elastin. Cardiovasc Res. 1969; 3: 161–170.
  • 20
    Eyre D, Poz M. Cross-linking in collagen and elastin. Annu Rev Biochem. 1984; 53: 717–748.
  • 21
    Brookner C, Follen M, Boiko I, et al. Tissue slices autofluorescence patterns in fresh cervical tissue. Photochem Photobiol. 2000; 71: 730–736.
  • 22
    Drezek R, Brookner C, Pavlova I, et al. Autofluorescence microscopy of fresh cervical tissue sections reveals alterations in tissue biochemistry with dysplasia. Photochem Photobiol. 2000; 71: 730–736.
  • 23
    Bailey AJ, Paul RG, Knott L. Mechanisms of maturation and ageing of collagen. Mech Ageing Dev. 1998; 106: 1–56.
  • 24
    Mahadevan A, Mitchell M, Silva E, Thomsen S, Richards-Kortum R. A study of the fluorescence properties of normal and neoplastic human cervical tissue. Lasers Surg Med. 1993; 13: 647–655.
    Direct Link:
  • 25
    Ramanujam N, Mitchell M, Mahadevan A, et al. Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo. Lasers Surg Med. 1996; 19: 46–62.
    Direct Link:
  • 26
    Ramanujam N, Mitchell M, Mahadevan A, et al. Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser induced fluorescence spectra at multiple excitation wavelengths. Lasers Surg Med. 1996; 19: 63–74.
    Direct Link:
  • 27
    Ramanujam N, Mitchell M, Mahadevan-Jansen A, et al. Cervical pre-cancer detection using a multivariate statistical algorithm based on laser induced fluorescence spectra at multiple excitation wavelengths. Photochem Photobiol. 1996; 6: 720–735.
    Direct Link:
  • 28
    Tromberg B. Detection of cervical pre-cancer using reflectance spectroscopy. Presented at the Office of Women's Health Symposium on Biomedical Optical Diagnostics and Imaging, Washington, DC, October 1997.
  • 29
    Mourant J, Bigio I, Boyer J, Conn R, Johnson T, Shimada T. Spectroscopic diagnosis of bladder cancer with elastic light scattering. Lasers Surg Med. 1995; 17: 350–357.
    Direct Link:
  • 30
    Zeng H, MacAulay C, McLean DI, Palcic B. Reconstruction of in vivo skin autofluorescence spectrum from microscopic properties by Monte Carlo simulation. J Photochem Photobiol B. 1997; 38: 234–240.
  • 31
    Zangaro RA, Silveira L, Manoharan R, et al. Rapid multi- excitation fluorescence spectroscopy system for in vivo tissue diagnosis. Appl Opt. 1997; 35: 5211–5219.
  • 32
    Zuclich JA, Shimada T, Loree TR, Bigio I, Strobl K, Nie S. Rapid noninvasive optical characterization of the human lens. Lasers Life Sci 1994; 6: 39–53.
  • 33
    Zuluaga A, Utzinger U, Durkin A, et al. Fluorescence excitation emission matrices of human tissue: a system for in vivo measurement and data analysis. Appl Spectrosc. 1999; 53: 302–311.
  • 34
    Wright TC, Ferenczy A, Wray S, Christianson R, Ganguly D. Detection of squamous intraepithelial lesions using evoked tissue fluorescence [abstract]. Gynecol Oncol. 1999; 72: 458.
  • 35
    Ferris DG, Lawhead RA, Dickman ED, et al. Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia. J Lower Genital Tract Dis. 2001; 2: 65–72.
    Direct Link:
  • 36
    Georgakoudi I, Sheets EE, Muller MG, et al. Tri-modal spectroscopy for the detection and characterization of cervical pre-cancers in vivo. Am J Obstet Gynecol. 2002; 186: 374–382.
  • 37
    Gurjar R, Backman V, Perelman LT, et al. Imaging human epithelial properties with polarized light scattering spectroscopy. Nat Med. 2001; 7: 1245–1248.
  • 38
    Collier T, Shen P, de Pradier B, et al. Near real time confocal microscopy of amelanotic tissue: dynamics of aceto-whitening enable nuclear segmentation. Opt Express. 2000; 6: 40–48.
  • 39
    Collier T, Lacy A, Malpica A, Follen M, Richards-Kortum R. Near real time confocal microscopy of amelanotic tissue: detection of dysplasia in ex-vivo cervical tissue. Acad Radiol. 2002; 9: 504–512.
  • 40
    Fahs MC, Mandelblatt J, Schechter C, Muller C. Cost effectiveness of cervical cancer screening for the elderly. Ann Intern Med. 1992; 117: 520–527.
  • 41
    Fujimoto JG, Pitris C, Boppart SA, Brezinski ME. Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia. 2000; 2: 9–25.
  • 42
    Sweeney TJ, Mailänder V, Tucker AA, et al. Visualizing the kinetics of tumor cell clearance in living animals. Proc Natl Acad Sci U S A. 1999; 96: 12044–12049.
  • 43
    Rehemtulla A, Stegman LD, Cardozo SJ, et al. Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging. Neoplasia. 2000; 2: 491–495.
  • 44
    Contag CH, Jenkins D, Contag PR, Negrin RS. Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia. 2000; 2: 41–52.
View Full Article (HTML) Get PDF (424K)