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Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers

  1. Kazuya Kondo M.D., Ph.D.1,†,*,
  2. Yuji Takahashi M.D.1,
  3. Sumiyo Ishikawa2,
  4. Hiroshi Uchihara2,
  5. Yukiko Hirose M.D.1,
  6. Kiyoshi Yoshizawa M.D., Ph.D.3,
  7. Masaru Tsuyuguchi M.D., Ph.D.4,
  8. Hiromitsu Takizawa M.D.1,
  9. Takanori Miyoshi M.D., Ph.D.1,
  10. Shoji Sakiyama M.D., Ph.D.1,
  11. Yasumasa Monden M.D., Ph.D.1

Article first published online: 14 OCT 2003

DOI: 10.1002/cncr.11818

Issue

Cancer

Cancer

Volume 98, Issue 11, pages 2420–2429, 1 December 2003

Additional Information

How to Cite

Kondo, K., Takahashi, Y., Ishikawa, S., Uchihara, H., Hirose, Y., Yoshizawa, K., Tsuyuguchi, M., Takizawa, H., Miyoshi, T., Sakiyama, S. and Monden, Y. (2003), Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers. Cancer, 98: 2420–2429. doi: 10.1002/cncr.11818

Author Information

  1. 1

    Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan

  2. 2

    Horiba Ltd., Kyoto, Japan

  3. 3

    Department of Surgery, Takamatsu Red Cross Hospital, Takamatsu, Japan

  4. 4

    Department of Surgery, Tokushima Municipal Hospital, Tokushima, Japan

  1. †

    Fax: (011) 81 88 633 7144

*Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, 3-chome, Kuramoto-cho, Tokushima City 770-8503, Japan

Publication History

  1. Issue published online: 17 NOV 2003
  2. Article first published online: 14 OCT 2003
  3. Manuscript Accepted: 1 SEP 2003

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REFERENCES

  • 1
    American Institute for Cancer Research. Food, nutrition and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research, 1997.
  • 2
    Kreyberg L. An etiology of lung cancer—a morphological, epidemiological and experimental analysis. Oslo: Oslo Universitetsforlaget, 1969: 1–90.
  • 3
    Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst. 1999; 91: 1194–1210.
  • 4
    International Agency for Research on Cancer. Chromium and certain chromium compounds. In: International Agency for Research on Cancer. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Lyon: IARC Press, 1982: 91–93.
  • 5
    Mikalsen A, Alexander L, Wallin H, Ingelman-Sundberg M, Andersen RA. Reductive metabolism and protein binding of chromium(VI) by P450 protein enzymes. Carcinogenesis. 1991; 12: 825–831.
  • 6
    Sano T. [Occupational cancers in chromate workers]. In: SanoT. [Pneumoconiosis and public hazards by dusts in Japan (2nd edition)]. Kawasaki: Institute for Science of Labour, 1983: 315–325.
  • 7
    Tsuneta Y. [Investigations of the pathogenesis of lung cancer observed among chromate factory workers]. Hokkaido Igaku Zasshi. 1982; 57: 175–187.
  • 8
    International Agency for Research on Cancer. Chromium, nickel and welding. In: International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Lyon: IARC Press, 1990: 49–255.
  • 9
    Hyodo K, Suzuki S, Furuya N, Meshizuka K. An analysis of chromium, copper, and zinc in organs of a chromate worker. Int Arch Occup Environ Health. 1980; 46: 141–150.
  • 10
    Kollmeier H, Witting C, Seemann J, Wittig P, Rothe R. Increased chromium and nickel content in lung tissue. J Cancer Res Clin Oncol. 1985; 110: 173–176.
  • 11
    Ishikawa Y, Nakagawa K, Sato Y, et al. “Hot spots” of chromium accumulation at bifurcations of chromate workers' bronchi. Cancer Res. 1994; 54: 2342–2346.
  • 12
    Hosokawa Y, Ozawa S, Nakazawa Y. An X-ray guide tube and a desk-top scanning X-ray analytical microscope. X-Ray Spectrom. 1997; 26: 380–387.
    Direct Link:
  • 13
    Hirose T, Kondo K, Takahashi Y, et al. Frequent microsatellite instability in lung cancer from chromate-exposed workers. Mol Carcinog. 2002; 33: 172–180.
    Direct Link:
  • 14
    Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998; 58: 5248–5257.
  • 15
    Yoshizawa K. [Clinicopathological analysis of lung cancer and epithelial changes of the bronchus in chromate workers]. Shikoku Igaku Zasshi. 1984; 40: 123–134.
  • 16
    Lippmann M, Albert RE. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J. 1969; 30: 257–275.
  • 17
    Kim S, Iwai Y, Fujino M, Furumoto M, Sumino K, Miyasaki K. Chromium-induced pulmonary cancer. Report of a case and a review of the literature. Acta Pathol Jpn. 1985; 35: 643–654.
  • 18
    Schulz H, Brand P, Heyder J. Particle deposition in the respiratory tract. In: GehrP, HeyderJ, editors. Particle-lung interactions. Lung biology in health and disease, volume 143. New York: Marcel Dekker, 2000: 229–290.
  • 19
    Baetjer AW, Damron C, Budacz Y. The distribution and retention of chromium in men and animals. Am Med Assoc Arch Ind Health. 1958; 20: 136–147.
  • 20
    Sano T. [Pathology of chromium disturbance]. J Sci Labor. 1978; 33: 4–14.
  • 21
    Tsuneta I, Mikami H, Kimura K, et al. [The concentration of chromium in the respiratory tract among chromate workers with lung cancer]. Hai-gann. 1978; 18: 341–347.
  • 22
    Kishi R, Tarumi T, Uchino E, Miyake H. Chromium content of organs of chromate workers with lung cancer. Am J Ind Med. 1987; 11: 67–74.
    Direct Link:
  • 23
    Geiser M, Hof VI, Gehr P, Schurch S. Structural and interfacial aspects of particle retention. In: GehrP, HeyderJ, editors. Particle-lung interactions. Lung biology in health and disease, volume 143. New York: Marcel Dekker, 2000: 229–290.
  • 24
    Levy LS, Martin PA, Bidstrup PL. Investigation of the potential carcinogenicity of a range of chromium containing materials on rat lung. Br J Ind Med. 1986; 43: 243–256.
  • 25
    Auerbach O, Stout AP, Hammond EC, Garfinkel L. Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. N Engl J Med. 1961; 265: 253–267.
  • 26
    Jinot J. Hazard identification I: lung cancer in active smokers, long-term animal bioassays, and genotoxicity studies. In: U.S. Environmental Protection Agency. Respiratory health effects of passive smoking: lung cancer and other disorders. Washington, DC: U.S. Environmental Protection Agency, 1993: 83–108.
  • 27
    Kondo K, Hino N, Sasa M, et al. Mutations of the p53 gene in human lung cancer from chromate-exposed workers. Biochem Biophys Res Commun. 1997; 239: 95–100.
  • 28
    Ewis AA, Kondo K, Lee J, et al. Occupational cancer genetics: infrequent ras oncogenes point mutations in lung cancer samples from chromate workers. Am J Ind Med. 2001; 40: 92–97.
    Direct Link:
  • 29
    Sozzi G, Miozzo M, Pastorino U, et al. Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions. Cancer Res. 1995; 55: 135–140.
  • 30
    Wistuba II, Behrens C, Milchgrub S, et al. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene. 1999; 18: 643–650.
  • 31
    Belinsky SA, Nikula KJ. Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci U S A. 1998; 95: 11891–11896.
  • 32
    Lamy A, Sesboue R, Bourguignon J, et al. Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: a prospective study in high-risk patients without invasive cancer. Int J Cancer. 2002; 100: 189–193.
    Direct Link:
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