Original Article

You have full text access to this OnlineOpen article

Is endometrial carcinoma intrinsically more aggressive in elderly patients?

  1. Kaled M. Alektiar M.D.1,†,*,
  2. Ennapadam Venkatraman Ph.D.2,
  3. Nadeem Abu-Rustum M.D.3,
  4. Richard R. Barakat M.D.3

Article first published online: 22 OCT 2003

DOI: 10.1002/cncr.11830

Issue

Cancer

Cancer

Volume 98, Issue 11, pages 2368–2377, 1 December 2003

Additional Information

How to Cite

Alektiar, K. M., Venkatraman, E., Abu-Rustum, N. and Barakat, R. R. (2003), Is endometrial carcinoma intrinsically more aggressive in elderly patients?. Cancer, 98: 2368–2377. doi: 10.1002/cncr.11830

Author Information

  1. 1

    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York

  2. 2

    Department of Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York

  3. 3

    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York

  1. †

    Fax: (212) 639-2417

*Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021

Publication History

  1. Issue published online: 17 NOV 2003
  2. Article first published online: 22 OCT 2003
  3. Manuscript Accepted: 4 SEP 2003
  4. Manuscript Revised: 27 AUG 2003
  5. Manuscript Received: 20 MAY 2003

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (112K)

REFERENCES

  • 1
    Kosary CL. FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. Semin Surg Oncol. 1994; 10: 31–46.
    Direct Link:
  • 2
    Zaino RJ, Kurman RJ, Diana KL, et al. Pathologic models to predict outcome for women with endometrial adenocarcinoma: the importance of the distinction between surgical stage and clinical stage–a Gynecologic Oncology Group study. Cancer. 1996; 77: 1115–1121.
    Direct Link:
  • 3
    Abeler VM, Kjorstad KE. Endometrial adenocarcinoma in Norway: a study of a total population. Cancer. 1991; 67: 3093–3103.
    Direct Link:
  • 4
    Irwin C, Levin W, Fyles A, et al. The role of adjuvant radiotherapy in carcinoma of the endometrium–results in 550 patients with pathologic stage I disease. Gynecol Oncol. 1998; 70: 247–254.
  • 5
    Poulsen MG, Roberts SJ. Prognostic variables in endometrial carcinoma. Int J Radiat Oncol Biol Phys. 1987; 13: 1043–1052.
  • 6
    Mundt AJ, Waggoner S, Yamada D, et al. Age as a prognostic factor for recurrence in patients with endometrial carcinoma. Gynecol Oncol. 2000; 79: 79–85.
  • 7
    Grigsby PW, Perez CA, Kuten A, et al. Clinical stage I endometrial cancer: prognostic factors for local control and distant metastasis and implications of the new FIGO surgical staging system. Int J Radiat Oncol Biol Phys. 1992; 22: 905–911.
  • 8
    Lindahl B, Ranstam J, Willen R. Five year survival rate in endometrial carcinoma stages I—II: influence of degree of tumour differentiation, age, myometrial invasion and DNA content. Br J Obstet Gynaecol. 1994; 101: 621–625.
  • 9
    Alektiar KM, McKee A, Venkatraman E, et al. Intravaginal high-dose-rate brachytherapy for Stage IB (FIGO Grade 1, 2) endometrial cancer. Int J Radiat Oncol Biol Phys. 2002; 53: 707–713.
  • 10
    Samet J, Hunt WC, Key C, et al. Choice of cancer therapy varies with age of patient. JAMA. 1986, 27; 255(24): 3385–3390
  • 11
    Schrag D, Cramer LD, Bach PB, et al. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst. 2001; 93: 850–857.
  • 12
    Larson DM, Broste SK, Krawisz BR. Surgery without radiotherapy for primary treatment of endometrial cancer. Obstet Gynecol. 1998; 91: 355–359.
  • 13
    Straughn JM Jr., Huh WK, Kelly FJ, et al. Conservative management of stage I endometrial carcinoma after surgical staging. Gynecol Oncol. 2002; 84: 194–200.
  • 14
    Alektiar K, McKee A, Lin O, et al. Is there a difference in the outcome between stage I-II endometrial cancer of papillary serous/clear cell and endometrioid FIGO grade 3? Int J Radiat Oncol Biol Phys. 2002; 54: 79–85.
  • 15
    Yates F. The analysis of multiple classifications with unequal numbers in different classes. J Am Stat Assoc. 1934; 29: 51.
  • 16
    Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958; 53: 457–481.
  • 17
    Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1966; 50: 163–170.
  • 18
    Cox DR. Regression models and life-tables. J R Stat Soc B. 1972; 34: 187–220.
  • 19
    Jemal A, Murray T, Samuels A, et al. Cancer statistics. CA Ca J Clin. 2003; 53: 5–26.
    Direct Link:
  • 20
    Creasman WT, Odicino F, Maisonneuve P, et al. Carcinoma of the corpus uteri. J Epidemiol Biostat. 2001; 6: 45–86.
  • 21
    Creutzberg CL, van Putten WL, Koper PC, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomized trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 2000; 355: 1404–1411.
  • 22
    Abeler VM, Vergote IB, Kjorstad KE, Trope CG. Clear cell carcinoma of the endometrium. Prognosis and metastatic pattern. Cancer. 1996 15; 78: 1740–1747.
    Direct Link:
  • 23
    Stewart KD, Martinez AA, Weiner S, et al. Ten-year outcome including patterns of failure and toxicity for adjuvant whole abdominopelvic irradiation in high-risk and poor histologic feature patients with endometrial carcinoma. Int J Radiat Oncol Biol Phys. 2002; 54: 527–535.
  • 24
    Pignon T, Horiot JC, Bolla M, et al. Age is not a limiting factor for radical radiotherapy in pelvic malignancies. Radiother Oncol. 1997; 42: 107–120.
  • 25
    Creutzberg CL, van Putten WL, Koper PC, et al.; PORTEC Study Group. The Postoperative Radiation Therapy in Endometrial Carcinoma. The morbidity of treatment for patients with Stage I endometrial cancer: results from a randomized trial. Int J Radiat Oncol Biol Phys. 2001; 51: 1246–1255.
  • 26
    Manton KG, Vaupel JW. Survival after the age of 80 in the United States, Sweden, France, England, and Japan. N Engl J Med. 1995; 333: 1232–1235.
  • 27
    Taeuber CM. Sixty-five plus in America. Revised edition. Current population report, special studies. Washington, DC: U.S. Government Printing Office, 1993; 23–178 RV.
  • 28
    Scribner DR Jr., Walker JL, Johnson GA, McMeekin SD, Gold MA, Mannel RS. Surgical management of early-stage endometrial cancer in the elderly: is laparoscopy feasible? Gynecol Oncol. 2001; 83: 563–568.
  • 29
    Mundt AJ, Lujan AE, Rotmensch J, et al. Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2002; 52: 1330–1337.
  • 30
    Ceccaroni M, D'Agostino G, Ferrandina G, et al. Gynecological malignancies in elderly patients: is age 70 a limit to standard-dose chemotherapy? An Italian retrospective toxicity multicentric study. Gynecol Oncol. 2002; 85: 445–450.
  • 31
    Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999; 341: 2061–2067.
View Full Article (HTML) Get PDF (112K)