Fax: (713) 794-4662
Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors
A pilot case–control analysis
Article first published online: 15 DEC 2003
Copyright © 2003 American Cancer Society
Volume 100, Issue 3, pages 561–567, 1 February 2004
How to Cite
Zheng, R., Wang, L.-E., Bondy, M. L., Wei, Q. and Sturgis, E. M. (2004), Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors. Cancer, 100: 561–567. doi: 10.1002/cncr.11944
- Issue published online: 20 JAN 2004
- Article first published online: 15 DEC 2003
- Manuscript Accepted: 4 NOV 2003
- Manuscript Revised: 30 OCT 2003
- Manuscript Received: 20 JUN 2003
- University of Texas M. D. Anderson Cancer Center. Grant Number: P30 CA l6672
- NIH. Grant Numbers: K12 CA 88084, R01 ES 11740
- malignant salivary gland tumors;
- adenoid cystic carcinoma;
- benign salivary gland tumors;
- mutagen sensitivity;
- gamma radiation;
- DNA repair
The salivary gland is a highly radiosensitive organ. Exposure to gamma radiation is a risk factor for both malignant (MSTs) and benign salivary gland tumors (BSTs), but the exact mechanisms remain unknown. The objectives of the current study were to determine whether gamma radiation–induced chromatid breaks increase the risk of MSTs and BSTs and whether there is any difference in risk between these two diseases.
The authors performed a pilot case–control study of 57 patients with salivary gland diseases (45 patients with MSTs and 12 patients with BSTs) and 105 cancer-free controls. Peripheral blood lymphocytes from these participants were cultured and exposed to gamma radiation (1.5 grays). Five hours later, metaphase spread slides were evaluated. The chromatid breaks in 50 well-spread metaphase slides were counted to determine the average number of chromatid breaks per cell (b/c).
Multivariate logistic regression analyses revealed that gamma radiation–induced b/c values greater than the median of the controls were a significant risk factor for salivary gland tumors (adjusted odds ratio [OR], 17.25; 95% confidence interval [CI], 4.92–60.49). The risk remained significant for MSTs (adjusted OR, 40.45; 95% CI, 5.27–310.17) but was of borderline significance for BSTs (adjusted OR, 4.73; 95% CI, 0.94–23.87) when these tumors were analyzed separately.
In the current study, high levels of chromatid breaks in lymphocytes induced by gamma irradiation were associated with an independent risk for MSTs and were likely to increase the risk of BSTs. However, larger studies are needed to verify these findings. Cancer 2004. © 2003 American Cancer Society.