The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

Authors

  • Ishaan Kalha M.D.,

    1. Department of Gastrointestinal Medicine/Nutrition, and Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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  • Madhukar Kaw M.D.,

    Corresponding author
    1. Department of Gastrointestinal Medicine/Nutrition, and Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
    • Clinical Associate Professor, The University of Texas M. D. Anderson Cancer Center and The University of Texas–Houston Medical School, 12121 Richmond Avenue, Suite 424, Houston, TX 77082
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    • Fax: (832) 379-1928

  • Norio Fukami M.D.,

    1. Department of Gastrointestinal Medicine/Nutrition, and Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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  • Mihir Patel M.D.,

    1. Department of Gastrointestinal Medicine/Nutrition, and Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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  • Sandeep Singh M.D.,

    1. Department of Gastrointestinal Medicine/Nutrition, and Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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  • Harish Gagneja M.D.,

    1. Department of Gastrointestinal Medicine/Nutrition, and Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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  • Deborah Cohen M.S.,

    1. Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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  • Jeffrey Morris Ph.D.

    1. Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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  • Presented in part at the annual meeting of the American College of Gastroenterology, Las Vegas, Nevada, October, 2001

Abstract

BACKGROUND

Endoscopic ultrasound (EUS) is an accurate staging modality for esophageal malignancy. Studies have determined that EUS does not retain this accuracy after chemoradiation and that it should not be used as a restaging tool for esophageal carcinoma. In this study, the authors examined their experience with esophageal carcinoma and restaging after neoadjuvant therapy with EUS.

METHODS

A retrospective chart review was conducted that included 83 patients with locoregional esophageal adenocarcinoma who were treated with chemoradiation under protocol. All patients underwent surgical resection. EUS was performed for restaging, and the results were compared with findings at surgical pathology using the TNM classification system.

RESULTS

All 83 patients identified underwent surgery. There were 77 males, and the mean patient age was 59 years. At restaging, the tumor status (T classification) was assessed correctly by EUS in 22 of 83 patients (29%). The sensitivity of EUS for the individual T classifications were 0% for T0 tumors, 19% for T1 tumors, 27% for T2 tumors, 52% for T3 tumors, and 0% for T4 tumors. In 19 of 83 patients, the tumor classification was correct, whereas 42 of 83 patients were over classified, and 15 of 83 patients were under classified when the EUS results were compared with the surgical pathology results. The lymph node status (N classification) was assessed correctly by EUS in 41 of 83 patients. The sensitivity of EUS for N classification was 48% for N0 disease and 52% for N1 disease. Twenty-two patients were restaged with residual disease according to the EUS results but had no evidence of residual tumor or lymph node involvement according to the surgical pathology results.

CONCLUSIONS

EUS did not retain its usefulness as a restaging modality after neoadjuvant chemoradiation for esophageal adenocarcinoma when the standard TNM classification system was used. Cancer 2004. © 2004 American Cancer Society.

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