Fax: (713) 745-3475
Chinese version of the M. D. Anderson Symptom Inventory
Validation and application of symptom measurement in cancer patients
Article first published online: 31 AUG 2004
Copyright © 2004 American Cancer Society
Volume 101, Issue 8, pages 1890–1901, 15 October 2004
How to Cite
Wang, X. S., Wang, Y., Guo, H., Mendoza, T. R., Hao, X.-S. and Cleeland, C. S. (2004), Chinese version of the M. D. Anderson Symptom Inventory. Cancer, 101: 1890–1901. doi: 10.1002/cncr.20448
- Issue published online: 1 OCT 2004
- Article first published online: 31 AUG 2004
- Manuscript Accepted: 20 MAY 2004
- Manuscript Revised: 13 MAY 2004
- Manuscript Received: 4 MAR 2004
- Hawn Foundation (Dallas, TX)
- assessment tool;
- factor analysis;
Symptom management is an essential component of cancer treatment for patients of every culture and nationality. Symptom assessment depends on subjective reporting, mandating linguistically equivalent versions of symptom assessment scales. Because disease-related and treatment-related symptoms most often occur in clusters, there is a global need for a standardized multiple-symptom assessment tool.
The authors sought to validate the Chinese version of the M. D. Anderson Symptom Inventory (MDASI-C) by enrolling patients who had received various diagnoses of and different types of treatment for cancer (n = 249) in a cross-sectional symptom study conducted at an urban cancer center in China.
Factor analysis identified 2 underlying constructs, general symptoms and gastrointestinal symptoms, which had Cronbach alpha coefficients of 0.86 and 0.84, respectively. These results were consistent with English- and Japanese-language MDASI validation studies. Known-group validity was supported by the MDASI-C's ability to detect significant differences in symptom and interference levels according to Eastern Cooperative Oncology Group performance status (ECOG PS; P < 0.001) and chemotherapy status (P < 0.05). Fifty-five percent of the study cohort had ≥ 1 symptom that was considered severe (score ≥ 7 on a 0–10 scale). ECOG PS was strongly associated with symptom burden (total interference score: R2 = 0.26; P < 0.001). Fatigue, sadness, drowsiness, and lack of appetite accounted for most of the variability in the total interference score (R2 = 0.49; P < 0.05).
The authors demonstrated that the MDASI-C is a valid, reliable, and concise tool for measuring symptom severity and interference with functioning in Chinese cancer patients. Cancer 2004. © 2004 American Cancer Society.