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Pretreatment probability model for predicting outcome after intraarterial chemoradiation for advanced head and neck carcinoma
Article first published online: 9 SEP 2004
Copyright © 2004 American Cancer Society
Volume 101, Issue 8, pages 1809–1817, 15 October 2004
How to Cite
van den Broek, G. B., Rasch, C. R. N., Pameijer, F. A., Peter, E., van den Brekel, M. W. M., Tan, I. B., Schornagel, J. H., de Bois, J. A., Zijp, L. J. and Balm, A. J. M. (2004), Pretreatment probability model for predicting outcome after intraarterial chemoradiation for advanced head and neck carcinoma. Cancer, 101: 1809–1817. doi: 10.1002/cncr.20556
- Issue published online: 1 OCT 2004
- Article first published online: 9 SEP 2004
- Manuscript Accepted: 1 JUL 2004
- Manuscript Revised: 28 JUN 2004
- Manuscript Received: 13 APR 2004
- head and neck neoplasms;
- intraarterial infusions;
- selective-targeted chemoradiation (RADPLAT);
- tumor volume;
- prognostic factors
Concurrent chemoradiation is being used increasingly to treat patients with advanced-stage head and neck carcinoma. In the current study, a clinical nomogram was developed to predict local control and overall survival rates for individual patients who will undergo chemoradiation.
Ninety-two consecutive patients with UICC TNM Stage III/IV squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and supraglottic larynx were treated with selective-targeted chemoradiation (acronym: RADPLAT). All living patients had a minimum follow-up of 2 years. In addition to general factors, the following parameters were analyzed in a multivariable analysis: primary tumor volume, lymph node tumor volume, total tumor volume, lowest involved neck level, comorbidity, pretreatment hemoglobin level, pretreatment weight loss, and unilateral/bilateral intraarterial infusion. Relevant factors for local control and survival were analyzed using the Cox proportional hazards model.
At 5 years, the local control and overall survival rates for the whole group were 60% and 38%, respectively. Primary tumor volume (hazard ratio [HR], 1.03; P = 0.01) and unilateral infusion (HR, 5.05; P = 0.004) were found to influence local control significantly. Using tumor volume as a continuous variable, an adjusted risk ratio of 1.026 was found, indicating that each 1-cm3 increase in volume was associated with a 2.6% decrease in probability of local control. Primary tumor volume (HR, 1.01; P = 0.003), comorbidity (American Society of Anesthesiologists [ASA] physical status 1 vs. > 1; HR, 2.47; P = 0.01), lowest involved neck level (HR, 3.45; P = 0.007), and pretreatment weight loss > 10% (HR, 2.04; P = 0.02) were found to be significant predictors of worse overall survival. Variables from the multivariable analysis were used to develop a nomogram capable of predicting local control and overall survival.
Tumor volume was found to play a significant role in predicting local control and overall survival in patients with advanced-stage head and neck carcinoma who were treated with targeted chemoradiation. The nomograms may be useful for pretreatment selection of patients with advanced-stage head and neck carcinoma. Cancer 2004. © 2004 American Cancer Society.