Fax: (011) 39-06-30486559
Original Article
You have full text access to this OnlineOpen article
Conservative treatment of invasive bladder carcinoma by transurethral resection, protracted intravenous infusion chemotherapy, and hyperfractionated radiotherapy
Long-term results
Article first published online: 12 OCT 2004
DOI: 10.1002/cncr.20654
Copyright © 2004 American Cancer Society
Additional Information
How to Cite
Danesi, D. T., Arcangeli, G., Cruciani, E., Altavista, P., Mecozzi, A., Saracino, B. and Orefici, F. (2004), Conservative treatment of invasive bladder carcinoma by transurethral resection, protracted intravenous infusion chemotherapy, and hyperfractionated radiotherapy. Cancer, 101: 2540–2548. doi: 10.1002/cncr.20654
Publication History
- Issue published online: 16 NOV 2004
- Article first published online: 12 OCT 2004
- Manuscript Revised: 10 AUG 2004
- Manuscript Accepted: 10 AUG 2004
- Manuscript Received: 21 APR 2004
REFERENCES
- 1, , , et al. Selective bladder preservation by combination treatment of invasive bladder cancer. N Engl J Med. 1993; 329: 1377–1382.
- 2, , , et al. Organ-sparing treatment of advanced bladder cancer: a 10- year experience. Int J Radiat Oncol Biol Phys. 1994; 30/2: 261–266.
- 3, , , et al. Neoadjuvant combined modality program with selective organ preservation for invasive bladder cancer: results of Radiation Therapy Oncology Group phase II trial 8802. J Clin Oncol. 1996; 14: 119–126.
- 4, , , et al. Infiltrating cancer of the bladder: can radiochemotherapy be an alternative to cystectomy? J Urol (Paris). 1996; 102: 3–8.
- 5, , , et al. Bladder preservation by combined modality therapy for invasive bladder cancer. J Clin Oncol. 1997; 15: 1022–1029.
- 6, , , , , . Bladder preservation in muscle-invasive bladder cancer by conservative surgery and radiochemotherapy. Semin Surg Oncol. 2001; 20: 24–32.Direct Link:
- 7, , , et al. Combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term results. J Clin Oncol. 2002; 20: 3061–3071.
- 8, , , , : Radiation Therapy Oncology Group. Overview of bladder cancer trials in the Radiation Therapy Oncology Group. Cancer. 2003; 97(8 Suppl. ): 2115–2119.Direct Link:
- 9, , . Bladder cancer: realities and perspectives. Bull Cancer. 2003; 90: 61–67.
- 10, , , et al. Neoadjuvant M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) effect on the primary bladder lesion. J Urol. 1988; 139: 470–474.
- 11, , , et al. Neoadjuvant cisplatin, methotrexate and vinblastin for muscle invasive bladder cancer: long-term follow-up. J Urol. 1993; 150: 849–852.
- 12, , , et al. Phase III trial of neoadjuvant chemotherapy in patients with invasive bladder cancer treated with selective bladder preservation by combined radiation therapy and chemotherapy: initial results of Radiation Therapy Oncology Group 89-03. J Clin Oncol. 1998; 16: 3576–3583.
- 13, , , et al. Combined radiation and chemotherapy for invasive transitional-cell carcinoma of the bladder: a prospective study. J Clin Oncol. 1993; 11: 2150–2157.
- 14, , , et al. Combined treatment of invasive bladder carcinoma with transurethral resection, induction chemotherapy, and radical radiotherapy plus concomitant protracted infusion of cisplatin and 5-fluorouracil. A phase I study. Cancer. 1997; 80: 1464–1471.Direct Link:
- 15, , , et al. Combined hyperfractionated radiotherapy and protracted infusion chemotherapy in bladder cancer for organ preservation. Clin Ther. 1998; 149: 183–189.
- 16. Combined treatment of radiation and cis-diammine-dichloroplatinum (II): a review of experimental and clinical data. Int J Radiat Oncol Biol Phys. 1987; 13: 403–426.
- 17, , , . Cisplatin by continuous infusion with concurrent radiation in malignant tumors (a phase I-II study). In: RosenthalCJ, RotmanM, editors. Clinical application of continuous infusion chemotherapy and concomitant radiation therapy. New York: Plenum Press, 1986: 177–180.
- 18, , , et al. Combined 5-fluorouracil and irradiation for transitional cell carcinoma of the urinary bladder. Int J Radiat Oncol Biol Phys. 1990; 19: 693–699.
- 19, , , et al. Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-FU or ftorafur and x-rays. Int J Radiat Oncol Biol Phys. 1982; 8: 1923–1933.
- 20. Theoretical basis and clinical applications of 5-fluorouracil as a radiosensitizer. In: RosenthalCJ, RotmanM, editors. Clinical application of continuous infusion chemotherapy and concomitant radiation therapy. New York: Plenum Press, 1986: 113–124.
- 21, , , et al. Combination versus single agent therapy in effecting complete therapeutic response in human bladder cancer: analysis of cisplatin and/or 5-fluorouracil in an in vivo survival model. Cancer Res. 1994; 54: 475–481.
- 22, . Concomitant combination of radiotherapy and protracted venous infusion of anticancer drugs. In: Monduzzi, editor. Fifth international meeting on progress in radio-oncology. Salzburg: International Proceedings Division, 1995: 35–40.
- 23SobinLH, WittekindCH, editors. TNM classification of malignant tumors. 5th edition. New York: John Wiley & Sons, Inc., 1997.
- 24, , , et al. Cisplatin, methotrexate and vinblastine (CMV): an effective chemotherapy regimen for metastatic transitional cell carcinoma of the urinary tract: a Northern California Oncology Group study. J Clin Oncol. 1985; 3: 1463–1470.
- 25, . Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958; 53: 457–481.
- 26, , , et al. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol. 2001; 19: 666–675.
- 27, , , et al. Efficacy of radiochemotherapy with platin derivatives compared to radiotherapy alone in organ-sparing treatment of bladder cancer. Int J Radiat Oncol Biol Phys. 1998; 40: 121–127.
- 28, , , , . Irradiation therapy with multiple small fractions per day in urinary bladder cancer. Radiother Oncol. 1985; 4: 197–203.
- 29, . Dose fractionation and tumor repopulation in radiotherapy for bladder cancer. Radiother Oncol. 1991; 21: 163–170.
- 30, , , , . Radiotherapy for T2 and T3 carcinoma of the bladder: the influence of overall treatment time. Radiother Oncol. 1995; 36: 183–188.
- 31, , , et al. A phase I/II trial of transurethral surgery combined with concurrent cisplatin, 5-fluorouracil and twice daily radiation followed by selective bladder preservation in operable patients with muscle invading bladder cancer. J Urol. 1998; 160: 1673–1677.
- 32, , , et al. Tumor regression during radiation treatment as a guide to prognosis. Br J Radiol. 1979; 52: 972–977.
- 33, , . Prognostic significance of extent of tumor regression at completion of radiation therapy. Radiology. 1965; 84: 1100–1105.
- 34, , , et al. Muscle-invasive bladder cancer treated with external beam radiotherapy: pretreatment prognostic factors and the predictive value of cystoscopic re-evaluation during treatment. Radiother Oncol. 1998; 49: 149–155.
- 35, , , et al. Prognostic factors in invasive bladder carcinoma treated by combined modality protocol (organ-sparing approach). Int J Radiat Oncol Biol Phys. 2000; 46: 403–409.
- 36, , , et al. Organ conservation in invasive bladder cancer by transurethral resection, chemotherapy and radiation: results of a urodynamic and quality of life study on long-term survivors. J Urol. 2003; 170: 1772–1776.
- 37, , , et al. RTOG 97-06: initial report of a phase I-II trial of selective bladder conservation using TURBT, twice-daily accelerated irradiation sensitized with cisplatin, and adjuvant MCV combination chemotherapy. Int J Radiat Oncol Biol Phys. 2003; 57: 665–672.

1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470)