Dermatofibrosarcoma protuberans

Authors

  • William M. Mendenhall M.D.,

    Corresponding author
    1. Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida
    • Department of Radiation Oncology, University of Florida Health Science Center, P.O. Box 100385, Gainesville, FL 32610-0386
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    • Fax: (352) 265-0759

  • Robert A. Zlotecki M.D., Ph.D.,

    1. Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida
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  • Mark T. Scarborough M.D.

    1. Department of Orthopedic Surgery, University of Florida College of Medicine, Gainesville, Florida
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Abstract

In the current review, the authors set out to discuss the natural history and treatment of dermatofibrosarcoma protuberans (DFSP), a rare indolent cutaneous tumor. Approximately 10–15% of all DFSPs contain areas of fibrosarcoma (DFSP-FS), and such cases tend to exhibit more aggressive behavior. The optimal treatment for DFSP is resection with wide margins; the likelihood of local control associated with this procedure exceeds 90%. The probability of regional or distant metastases is ≤ 5%. Patients with positive or close surgical margins have an elevated risk of local recurrence after resection alone; however, postoperative radiotherapy results in local control rates of ≥ 85% in such patients. Postoperative radiotherapy also is indicated in the rare event that a patient has unresectable macroscopic disease. Experience with the use of radiotherapy alone to treat macroscopic disease is limited. Cancer 2004 © 2004 American Cancer Society.

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