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Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma
Article first published online: 1 DEC 2004
Copyright © 2004 American Cancer Society
Volume 103, Issue 2, pages 299–306, 15 January 2005
How to Cite
Sasaki, A., Kai, S., Iwashita, Y., Hirano, S., Ohta, M. and Kitano, S. (2005), Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma. Cancer, 103: 299–306. doi: 10.1002/cncr.20798
- Issue published online: 5 JAN 2005
- Article first published online: 1 DEC 2004
- Manuscript Accepted: 7 OCT 2004
- Manuscript Revised: 5 OCT 2004
- Manuscript Received: 22 MAR 2004
- hepatocellular carcinoma;
- portal invasion;
- intrahepatic metastasis;
- thermal ablation
Intrahepatic disease recurrence is observed frequently after locoregional therapies for patients with hepatocellular carcinoma (HCC). However, the indication for locoregional therapy is still unclear. To clarify the indication for locoregional therapy for small HCC tumors, the authors measured the distance of microsatellites from the main tumor and analyzed the relation between this distance and clinicopathologic factors.
The authors retrospectively analyzed 100 patients with small HCC tumors (≤ 5 cm in dimension) treated by curative hepatectomy. A microsatellite was defined as invasion into the portal vein or intrahepatic metastasis, and the distance from the main tumor to the most distant microsatellite was determined under light microscopy. The current study investigated the relation between microsatellite distance (0 mm if none present, ≤ 5 mm, and > 5 mm) and clinicopathologic factors, as well as overall and disease-free survival rates after hepatectomy.
Of the 100 patients, 46 had microsatellites with a mean distance of 9.9 mm (median, 5.0 mm). Of the clinicopathologic factors investigated, tumor grade and preoperative α-fetoprotein level significantly correlated with the presence of a microsatellite. Tumor size and distance to the microsatellite were significantly correlated. All but 1 tumor associated with a microsatellite distance > 5 mm was a high-grade tumor > 25 mm in greatest dimension. The overall survival rate of patients with a microsatellite distance of > 5 mm was lower than that of patients with a microsatellite distance < 5 mm.
Locoregional therapy, including limited resection and ablation therapies, was appropriate for patients with low-grade HCC tumors or with tumors < 25 mm in diameter. Cancer 2005. © 2004 American Cancer Society.