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Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma
Article first published online: 20 DEC 2004
DOI: 10.1002/cncr.20827
Copyright © 2004 American Cancer Society
Additional Information
How to Cite
Tanaka, R., Wang, D., Morishita, Y., Inadome, Y., Minami, Y., Iijima, T., Fukai, S., Goya, T. and Noguchi, M. (2005), Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma. Cancer, 103: 608–615. doi: 10.1002/cncr.20827
Publication History
- Issue published online: 20 JAN 2005
- Article first published online: 20 DEC 2004
- Manuscript Accepted: 18 OCT 2004
- Manuscript Revised: 3 OCT 2004
- Manuscript Received: 14 JUN 2004
REFERENCES
- 1
- 2, , , et al. Small adenocarcinoma of the lung—histologic characteristics and prognosis. Cancer. 1995; 75: 2844–2852.Direct Link:
- 3, , , , . Mechanisms of p16(INK4A) inactivation in non small-cell lung cancers. Oncogene. 1998; 16: 497–504.
- 4, , , , , . Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature. 1994; 368: 753–756.
- 5, , , et al. A cell-cycle regulator potentially involved in genesis of many tumor types. Science. 1994; 264: 436–440.
- 6, , , et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumor-suppressor p16/CDKN2/MTS1 in human cancers. Nature Med. 1995; 1: 686–692.
- 7. Revisions in the International System for Staging Lung Cancer. Chest. 1997; 111: 1710–1717.
- 8, , . Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun. 1985; 130: 118–126.
- 9, , , , . Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 1996; 93: 9821–9826.
- 10, , , et al. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res. 2000; 60: 5954–5958.
- 11, , , , , . CpG island methylation is a common finding in colorectal cancer cell lines. Br J Cancer. 2003; 88: 413–419.
- 12, , , et al. Loss of heterozygosity in primary lung cancer using laser capture microdissection and WAVE DNA fragment analysis techniques. Med Sci Monit. 2002; 8: BR95–BR99
- 13, , , , . Expression of cyclin D1, retinoblastoma gene protein, and p16 MTS1 protein in atypical adenomatous hyperplasia and adenocarcinoma of the lung—an immunohistochemical analysis. Virchows Arch. 1998; 432: 207–215.
- 14, , , , , . p16(INK4A) alterations are accompanied by aberrant protein immunostaining in endometrial carcinomas. J Cancer Res Clin Oncol. 2003; 129: 589–596.
- 15, , , et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA. 1998; 95: 11891–11896.
- 16, , , et al. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene. 1999; 18: 643–650.
- 17, , , et al. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer. 2003; 103: 153–160.Direct Link:

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