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Five-day courses of irinotecan as palliative therapy for patients with neuroblastoma
Article first published online: 6 JAN 2005
Copyright © 2005 American Cancer Society
Volume 103, Issue 4, pages 858–862, 15 February 2005
How to Cite
Kushner, B. H., Kramer, K., Modak, S. and Cheung, N.-K. V. (2005), Five-day courses of irinotecan as palliative therapy for patients with neuroblastoma. Cancer, 103: 858–862. doi: 10.1002/cncr.20846
- Issue published online: 3 FEB 2005
- Article first published online: 6 JAN 2005
- Manuscript Accepted: 27 OCT 2004
- Manuscript Revised: 20 OCT 2004
- Manuscript Received: 20 SEP 2004
- National Cancer Institute (Bethesda, MD). Grant Numbers: CA61017, CA72868
- Hope Street Kids (Alexandria, VA)
- Justin Zahn Fund (New York, NY)
- Katie's Find A Cure Fund (New York, NY)
- Robert Steel Foundation (New York, NY)
- antitumor cytotoxicity;
- novel therapeutics;
- salvage therapy
The authors describe a large experience using short courses of irinotecan for palliative therapy in patients with neuroblastoma (NB). Quality of life was a major issue in choosing this regimen for patients whose disease was resistant to standard anti-NB therapies.
A retrospective review was conducted of all patients who were followed by the Department of Pediatrics at Memorial Sloan-Kettering Cancer Center and treated for resistant NB with irinotecan at 50 mg/m2 per day for 5 days as a 1-hour intravenous infusion. Treatment was outpatient, and there was a minimum 2-week rest period between courses. Granulocyte colony-stimulating factor was used to keep the absolute neutrophil count > 500–1000/mL.
Forty-four patients had been treated aggressively and/or extensively before they received one or more five-day courses of irinotecan. Emetogenic, diarrheal, and myelosuppressive effects were readily managed. Hospitalizations were limited to three patients with bacteremia. Twenty-three patients had a change in therapy, although they did not have progressive disease (PD) after receiving 1 (n = 10), 2 (n = 3), 3 (n = 1), 4 (n = 6), 7 (n = 1 patient), 22 (n = 1 patient), or 24 (n = 1) courses. The most common reasons for changing treatment were to intensify retrieval therapy or to pursue immunotherapy. Of those 23 patients, 15 patients had stable disease, 7 were not evaluable for response because of concurrent radiotherapy, and 1 patient had a major response. Twenty-one patients had PD after 1 (n = 3, 2 (n = 9), 4 (n = 2), 5 (n = 1), 6 (n = 3), 7 (n = 1), 9 (n = 1), and 11 (n = 1) courses.
In heavily treated patients, the regimen studied was well tolerated, allowed patients to continue most normal life activities, and produced anti-NB effects. Its modest toxicity supported use with other antitumor agents. Cancer 2005. © 2005 American Cancer Society.