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Determinants of quality of life in patients with cancer
A South American study
Article first published online: 21 JAN 2005
Copyright © 2005 American Cancer Society
Volume 103, Issue 5, pages 1072–1081, 1 March 2005
How to Cite
Dapueto, J. J., Servente, L., Francolino, C. and Hahn, E. A. (2005), Determinants of quality of life in patients with cancer. Cancer, 103: 1072–1081. doi: 10.1002/cncr.20870
- Issue published online: 17 FEB 2005
- Article first published online: 21 JAN 2005
- Manuscript Accepted: 5 NOV 2004
- Manuscript Revised: 29 OCT 2004
- Manuscript Received: 31 MAY 2004
- Comisión Honoraria de Lucha Contra el Cáncer, Uruguay. Grant Number: 117
- determinants of quality of life;
- Functional Assessment of Cancer Therapy-General questionnaire;
- Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being scale;
- South America;
Because health-related quality of life (QOL) is an important outcome in cancer management, the authors sought to better understand its determinants. To address this subject, they analyzed QOL, as measured with the Functional Assessment of Cancer Therapy-General questionnaire (FACT-G), Spanish Version 4, and depicted the complex relations among physical, psychological, social, and cultural factors, including spirituality.
A cross-sectional study design was used with a sample of 309 patients with cancer. The influence of several possible determinants was first studied by univariate regression analysis. Variables showing an association were included in a forward stepwise multivariate regression model.
Five regression models were studied, for the FACT-G total score and its four subscales. Five variables explained 32.1% of the variance of the FACT-G total score: tumor stage, spiritual well-being, income, mood disorders, and mode of questionnaire administration. The type and relevance of the explanatory variables differed among the various dimensions of QOL.
The authors underlined the entwining of biologic, psychosocial, and spiritual factors as determinants of the QOL of patients with cancer, thus supporting the multidimensional definition and modeling of the construct. Cancer 2005. © 2005 American Cancer Society.