Drs. Howell and Mensah contributed equally to this work.
Detection of recurrence in childhood solid tumors
Article first published online: 26 JAN 2005
Copyright © 2005 American Cancer Society
Volume 103, Issue 6, pages 1274–1279, 15 March 2005
How to Cite
Howell, L., Mensah, A., Brennan, B. and Makin, G. (2005), Detection of recurrence in childhood solid tumors. Cancer, 103: 1274–1279. doi: 10.1002/cncr.20896
- Issue published online: 2 MAR 2005
- Article first published online: 26 JAN 2005
- Manuscript Accepted: 18 NOV 2004
- Manuscript Revised: 5 NOV 2004
- Manuscript Received: 2 SEP 2004
- childhood cancer;
- recurrence detection;
Frequent follow-up and regular investigation are routine in pediatric oncology. However, there is little evidence regarding their value in the detection of recurrent disease.
The authors carried out a retrospective study of the follow-up of 186 children with solid tumors who were diagnosed between 1992 and 1996. The numbers of clinic visits, follow-up investigations, and (if appropriate) the mode of recurrence detection were recorded.
The mean follow-up was 5.9 years. During this time, 37 recurrences were detected, symptomatically in 54% of patients, by routine investigation in 30% of patients, and at routine clinic appointment in 16% of patients. It was calculated that routine magnetic resonance imaging detected 1 recurrence for every 42 scans performed, routine computed tomography detected 1 recurrence for every 129 scans performed, and routine chest radiography detected 1 recurrence for every 257 films.
The current results raise questions regarding the usefulness of such follow-up in children with solid tumors. Cancer 2005. © 2005 American Cancer Society.