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A proposed explanation for female predominance in alveolar soft part sarcoma
Noninactivation of X; Autosome translocation fusion gene?
Article first published online: 3 FEB 2005
DOI: 10.1002/cncr.20899
Copyright © 2005 American Cancer Society
Additional Information
How to Cite
Bu, X. and Bernstein, L. (2005), A proposed explanation for female predominance in alveolar soft part sarcoma. Cancer, 103: 1245–1253. doi: 10.1002/cncr.20899
Publication History
- Issue published online: 2 MAR 2005
- Article first published online: 3 FEB 2005
- Manuscript Accepted: 24 NOV 2004
- Manuscript Revised: 21 NOV 2004
- Manuscript Received: 29 JUN 2004
REFERENCES
- 1, , . Alveolar soft part sarcoma: structurally characteristic tumors of uncertain histogenesis. Cancer. 1952; 5: 100–111.Direct Link:
- 2, , , et al. The precrystalline cytoplasmic granules of alveolar soft part sarcoma contain monocarboxylate transporter 1 and CD147. Am J Pathol. 2002; 160: 1215–1221.
- 3, . Soft tissue tumors (4th edition). St. Louis: Mosby, 2001: 1509–1521.
- 4, , , , . Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. Genes Chromosom Cancer. 1998; 23: 194–197.Direct Link:
- 5, , , et al. Chromosome rearrangement at 17q25 and Xp11.2 in alveolar soft-part sarcoma: a case report and review of the literature. Cancer. 1999; 86: 1246–1250.Direct Link:
- 6, , , et al. Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol. 2001; 159: 179–192.
- 7, , , et al. The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncongene. 2001; 20: 48–57.
- 8, , , et al. Localization of the X inactivation centre on human X chromosome in Xq13. Nature. 1991; 349: 82–84.
- 9, , , . XIST RNA paints the inactive X-chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J Cell Biol. 1996; 132: 259–275.
- 10, , , . X-inactivation pattern in three cases of X-autosome translocation. Am J Med Genet. 1978; 1: 309–317.Direct Link:
- 11, . Functional disomies of the X chromosome influence the cell selection and hence the X inactivation pattern in females with balanced X-autosome translocation: a review of 122 cases. Am J Med Genet. 1992; 42: 161–169.Direct Link:
- 12. Hypomelanosis of Ito and X;autosome translocations: a unifying hypothesis. J Med Genet. 1996; 33: 177–183.
- 13, , , . X inactivation analysis in a female with hypomelanosis of Ito associated with a balanced X;17 translocation: evidence for functional disomy of Xp. J Med Genet. 1996; 33: 216–220.
- 14, , , . Functional Xp disomy and hypomelanosis of Ito. Arch Med Research. 2000; 31: 88–92.
- 15, , , . A first-generation X-inactivation profile of the human X chromosome. Proc Natl Acad Sci. 1999; 96: 14440–14444.
- 16Surveillance, Epidemiology, and End Results (SEER) Program Public-Use Data (1973–1999), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2002, based on the November 2001 submission. SEER: Washington, DC.
- 17, , , . Alveolar soft-part sarcoma. JAMA. 1966; 198: 1047–1051.
- 18
- 19, . A report of two cases of alveolar soft part sarcoma and their histologic variations. Acta Pathol Jpn. 1957; 7: 851–855.
- 20
- 21
- 22, . Alveolar soft part sarcoma of the orbit. Arch Ophthalmol. 1966; 75: 496–499.
- 23, , . Alveolar soft-part sarcoma of the orbit. Arch Ophthalmol. 1968; 79: 185–188.
- 24
- 25
- 26, , . Alveolar soft-part sarcoma with invasion of bone. A case report. J Bone Joint Surg–Am. 1969; 51: 765–768.
- 27
- 28, , . Alveolar soft-part sarcoma. Report of a case presenting as a sacral bone tumor. J Bone Joint Surg Am. 1969; 51: 185–190.
- 29
- 30. Two rare tumours involving the infratemporal fossa: alveolar soft part sarcoma and haemangiopericytoma. J Laryngol Otol. 1975; 89: 375–389.
- 31. Radiation therapy in alveolar soft part sarcoma. Cancer. 1971; 28: 577–580.Direct Link:
- 32, , , . Cerebral manifestations of alveolar soft-part sarcoma. Radiology. 1971; 99: 109–115.
- 33, . Electron microscopic evidence suggesting the myogenous derivation of the so-called alveolar soft part sarcoma. Cancer. 1971; 27: 150–159.Direct Link:
- 34, . Alveolar soft-part sarcoma. Report of a case presenting as asymptomatic pulmonary nodules. Chest. 1972; 62: 762–763.
- 35
- 36, , , . Histogenesis of alveolar soft part sarcoma. Cancer. 1972; 29: 191–204.Direct Link:
- 37
- 38, , , et al. Skeletal metastases from soft-tissue sarcomas. Incidence, patterns, and radiological features. J Bone Joint Surg Brit. 1997; 79: 548–552.
- 39, , , et al. Brain metastases in musculoskeletal sarcomas. Jpn J Clin Oncol. 1999; 29: 245–247.
- 40, . The alveolar soft-part sarcoma. A clinically malignant, neuro-endocrine tumor, possibly originating from the tissue composing the paraganglia. Arch Chir Neerl. 1976; 28: 261–270.
- 41, , , . Alveolar soft part sarcoma of the nasal cavity and paranasal sinuses. J Laryngol Otol. 1977; 91: 1003–1008.
- 42, . Alveolar soft part sarcoma. Report of a case. Acta Chirurgica Scandinavica. 1977; 143: 375–376.
- 43, . Lymphography in alveolar soft part sarcoma. Clin Radiol. 1977; 28: 327–331.
- 44, . Malignant alveolar soft part sarcoma with pulmonary metastases. Ind J Chest Dis Allied Sci. 1978; 20: 36–38.
- 45. A clinicopathological study on soft tissue tumors of the head and neck. Acta Pathol Jpn. 1979; 29: 389–408.
- 46. Alveolar soft part sarcoma. J Surg Oncol. 1978; 10: 201–204.Direct Link:
- 47. Adolescent breast masses in Nigerian Igbos. Am J Surg. 1979; 137: 367–368.
- 48
- 49
- 50, , . A case of alveolar soft part sarcoma. Jpn J Cancer Clin. 1979; 25: 693.
- 51
- 52, , , et al. Alveolar soft part sarcoma in children and adolescents: a report from the Soft-Tissue Sarcoma Italian Cooperative Group. Ann Oncol. 2000; 11: 1445–1449.
- 53, , . Alveolar soft part sarcoma in the vagina: clinical features and morphology. Gynecol Oncol. 1980; 9: 227–236.
- 54, , . Touch imprints: their use in the frozen-section diagnosis of alveolar soft-part sarcoma. Arch Pathol Lab Med. 1981; 105: 263–265.
- 55, , , , . Various sympathetic derived human tumors differ in neurofilament expression. Use in diagnosis of neuroblastoma, ganglioneuroblastoma and pheochromocytoma. Virchows Arch B Cell Pathol Incl Mol Pathol. 1982; 40: 141–156.
- 56. Evidence supporting neural crest origin of an alveolar soft part sarcoma: an ultrastructural study. Cancer. 1982; 50: 507–514.Direct Link:
- 57, , . Alveolar soft-part sarcoma. Thorax. 1982; 37: 877–886.
- 58. Alveolar soft-part sarcoma. Am J Ophthalmol. 1982; 94: 554–556.
- 59, , , et al. Proteins of intermediate filaments. An immunohistochemical and biochemical approach to the classification of soft tissue tumors. Am J Pathol. 1983; 110: 193–208.
- 60, , , et al. An ultrastructural and histochemical study of alveolar soft part sarcoma with special reference to the nature of crystals. Acta Pathol Jpn. 1984; 34: 435–443.
- 61, , , . Alveolar soft part sarcoma: ultrastructural and immunohistological studies with monoclonal antibodies. Brit J Clin Prac. 1984; 38: 154–156.
- 62
- 63, , . Alveolar soft-part sarcoma of the tongue. Report of a case with electron microscopic study. Oral Surg Oral Med Oral Pathol. 1984; 57: 532–539.
- 64, , , , , . Alveolar soft part sarcoma presenting as asymptomatic pulmonary nodules: report of a case with ultrastructural diagnosis. Thorax. 1985; 40: 203–204.
- 65, , . Fine needle aspiration cytology of alveolar soft-part sarcoma. A case report. Acta Cytol. 1985; 29: 559–561.
- 66
- 67, , , et al. Surgery for multiple lung metastases from alveolar soft-part sarcoma. Surg Today. 1997; 27: 806–811.
- 68, . Adenosine triphosphatase activity of crystalline inclusions in alveolar soft part sarcoma. An ultrahistochemical study of a case. Pathol Res Prac. 1986; 181: 357–364.
- 69. Sarcoma metastatic to the brain. Cancer. 1988; 61: 593–601.Direct Link:
- 70, , . Alveolar soft-part sarcoma: a hormone-sensitive tumour? Postgrad Med J. 1988; 64: 386–388.
- 71, , . Misdiagnosed localized arteriovenous malformation. J Vasc Surg. 1988; 6: 419–421.
- 72, , , , . Alveolar soft part sarcoma: immunological evidence of rhabdomyoblastic differentiation. Histopathology. 1988; 13: 101–108.Direct Link:
- 73
- 74, , , . Alveolar soft part sarcoma. An immunohistochemical, cytologic and electron-microscopic study and a quantitative DNA analysis. Virchows Arch A Pathol Anat Histopathol. 1988; 412: 499–513.
- 75, , . Lingual metastasis of alveolar soft-part sarcoma. Oral Surg Oral Med Oral Pathol. 1988; 65: 742–744.
- 76
- 77, , . Alveolar soft part sarcoma of the cervix uteri. A case report. Pathol Res Prac. 1989; 184: 354–358.
- 78, . Alveolar soft-part sarcoma in the uterine cervix. Arch Pathol Lab Med. 1999; 113: 1179–1183.
- 79, , , . Alveolar soft part sarcoma of the tongue. J Laryngol Otol. 1989; 103: 952–954.
- 80, , , . Alveolar soft part sarcoma. Assessment of immunohistochemical demonstration of desmin using paraffin sections and frozen sections. Virchows Arch A Pathol Anat Histopathol. 1989; 414: 503–509.
- 81, . Alveolar soft part sarcoma of the uterus. Histopathology. 1990; 16: 97–99.Direct Link:
- 82, , , . Alveolar soft part sarcoma of the vagina. Tumori. 1990; 76: 77–80.
- 83, , , . Alveolar soft part sarcoma: a case report with immunohistochemical study. Jpn J Surg. 1990; 20: 476–480.
- 84, , , . Breast sarcoma. A clinicopathologic review of 25 cases. Cancer. 1990; 66: 941–944.Direct Link:
- 85, , , et al. Alveolar soft part sarcoma. A clinicopathologic and immunohistochemical study of 12 cases. Acta Pathol Jpn. 1990; 40: 199–205.
- 86, , , , , . Alveolar soft-part sarcoma of the tongue. Report of a case. Int J Oral Maxillofac Surg. 1990; 19: 110–112.
- 87, , , , . Cytoskeletal properties of alveolar soft part sarcoma. Hum Pathol. 1990; 21: 204–211.
- 88. Alveolar soft part sarcoma with psammoma bodies. Histopathology. 1990; 17: 188.Direct Link:
- 89, . Alveolar soft part sarcoma. Immunohistochemical evidence for muscle cell differentiation. Am J Clin Pathol. 1990; 93: 32–38.
- 90, . Alveolar soft part sarcoma of the pulmonary vein. Acta Pathol Jpn. 1991; 41: 771–777.
- 91
- 92, , , . Alveolar soft-part sarcoma of the uterine corpus: histological, immunocytochemical and ultrastructural study of a case. Virchows Arch A Pathol Anat Histopathol. 1991: 418: 467–471.
- 93, , , , , . Molecular genetic, cytogenetic, and immunohistochemical characterization of alveolar soft-part sarcoma. Implications for cell of origin. Cancer. 1992; 70: 2444–2450.Direct Link:
- 94, , , , . Imaging of alveolar soft part sarcoma. Clin Radiol. 1992; 46: 253–256.
- 95, , , et al. Hypervascular metastatic cardiac tumors: an unknown cause of mitral valve prolapse. Intern Med. 1992; 31: 78–81.
- 96, , . Alveolar soft part sarcoma presenting as a pulsating tumour of the arm in a young woman. Irish J Med Sci. 1992; 161: 12–13.
- 97, , , et al. Alveolar soft-part sarcoma: evidence for its myogenic origin and for the involvement of 17q25. Histopathology. 1993; 23: 439–444.Direct Link:
- 98, , , , . Alveolar soft part sarcoma. A rare tumor of unusual evolution in pediatrics. Am J Pediatr Hemat Oncol. 1993; 15: 435–438.
- 99, , , , , . Alveolar soft-part sarcoma. A report of ten cases. Clin Orthop Related Res. 1993; 294: 259–266.
- 100, , , , . Tc-99m HMDP accumulation in an alveolar soft part sarcoma. Clin Nucl Med. 1993; 18: 615.
- 101, , , . Alveolar soft part sarcoma of the uterine cervix. Acta Pathol Jpn. 1993; 43: 204–208.
- 102, , , . Alveolar soft part sarcoma of the tongue: a case report. Aust N Z J Surg. 1993; 63: 240–242.Direct Link:
- 103, , . Subcutaneous alveolar soft-part sarcoma mimicking metastatic hypernephroma. Brit J Clin Prac. 1993; 47: 342–343.
- 104, , , . Immunophenotype and ultrastructure of alveolar soft part sarcoma. J Submicrosc Cytol Pathol. 1993; 25: 377–387.
- 105, . Metastatic alveolar soft part sarcoma presenting as a dural-based cerebral mass. Neurosurgery. 1994; 34: 168–170.
- 106, , , , . Alveolar soft part sarcoma of the vagina. A case report. J Reprod Med. 1994; 39: 121–125.
- 107, , . Alveolar soft part sarcoma of the uterus: case report and review of the literature. Gynecol Oncol. 1994; 54: 91–94.
- 108, , , , , . Alveolar soft-part sarcoma of the orbit. Ophthalmic Surg. 1995; 26: 269–270.
- 109, , . Alveolar soft-part sarcoma of the oral cavity: report of a case and review of the literature. J Oral Maxillofac Surg. 1995; 53: 1203–1208.
- 110, , , , . The role of MR imaging in the diagnosis of alveolar soft part sarcoma: a report of 10 cases. Skeletal Radiol. 1995; 24: 267–270.
- 111, , , , , , . An important role for chromosome 17, band q25, in the histogenesis of alveolar soft part sarcoma. Cancer Genet Cytogenet. 1995; 82: 57–61.
- 112, , . Successful treatment for solitary brain metastasis from alveolar soft part sarcoma. J Neurooncol. 1995; 25: 161–166.
- 113
- 114, , . Alveolar soft part sarcoma. Skeletal Radiol. 1996; 25: 400–402.
- 115, , . Intracytoplasmic crystals of alveolar soft part sarcoma: demonstration by Riu's stain. Acta Cytol. 1997; 41: 1234–1236.
- 116, , , , , , . Breast mass due to alveolar soft part sarcoma of the pectoris major muscle. Eur J Radiol. 1997; 24: 57–59.
- 117, . Antegrade catheterization of the brachial artery for embolizing a sarcoma of the forearm. Br J Radiol. 1997; 70: 99–101.
- 118, , . Alveolar soft-part sarcoma with unusual mitochondrial findings: a case report. Ultrastruct Pathol. 1998; 22: 321–329.
- 119
- 120, , . Alveolar soft part sarcoma of the uterine corpus. Report of two cases and review of the literature. Pathol Res Prac. 1998; 194: 59–63.
- 121, , , , . Alveolar soft part sarcoma. Eur Radiol. 1998; 8: 813–816.
- 122, , , , , . Immunohistochemical examination of an orbital alveolar soft part sarcoma. Graefe Arch Clin Exp Ophthalmol. 1999; 237: 266–272.
- 123, , . Giemsa staining for alveolar soft part sarcoma. Acta Cytol. 1999; 43: 519–521.
- 124, , . Alveolar soft part sarcoma of the tongue. Brit J Oral Maxillofac Surg. 1999; 37: 451–454.
- 125, , , . Alveolar soft part sarcoma of the tongue. Report of a case. Int J Oral Maxillofac Surg. 2000; 29: 370–372.
- 126, , , , , . Alveolar soft-part sarcoma of the cheek: report of a case with a review of the literature. Int J Oral Maxillofac Surg. 2000; 29: 366–369.
- 127, , , et al. Alveolar soft part sarcoma: MR and angiographic findings. Skeletal Radiol. 2000; 29: 680–689.
- 128, , , et al. APC and beta-catenin in alveolar soft part sarcoma (ASPS)—immunohistochemical and molecular genetic analysis. Pathol Res Prac. 2000; 196: 299–304.
- 129, , , , . Alveolar soft-part sarcoma: a rare soft-tissue malignancy with distinctive clinical and radiological features. Pediatr Radiol. 2001; 31: 196–199.
- 130, , , , . Cytogenetic abnormalities of alveolar soft-part sarcomas using interphase fluorescent in situ hybridization: trisomy for chromosome 7 and monosomy for chromosomes 8 and 18 seem to be characteristic of the tumor. Virchows Arch. 2001; 438: 173–180.
- 131, , , . Alveolar soft-part sarcoma of the cheek. Brit J Oral Maxillofac Surg. 2001; 39: 394–397.
- 132, , et al. Pancreatic metastasis of alveolar soft-part sarcoma: a case report and review of the literature. Ann Oncol. 2001; 12: 865–867.
- 133, , , , . Alveolar soft part sarcoma with lung metastases. Response to interferon alpha-2a? Med Pediatr Oncol. 2001; 37: 482–483.Direct Link:
- 134, , . Reduced risk of synovial sarcoma in females: X-chromosome inactivation? Br J Cancer. 2002; 87: 28–30.
- 135International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature. 2001; 409: 860–921.
- 136, , , , . Renal adenocarcinoma in an 8-year-old child, with a t(X;17)(p11.2;q25). Cancer Genet Cytogenet. 1995; 83: 82–83.
- 137, , , et al. Renal cell carcinoma in children. A different disorder from its adult counterpart? Med Pediatr Oncol. 1998; 31: 153–158.Direct Link:

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