In the April 1, 2005, issue of Cancer, an article entitled “Tumor necrosis factor enhances SN38-mediated apoptosis in mesothelioma cells: The role of nuclear factor-κB pathway activation” was published by Dr. Russo and colleagues. On October 6, 2009, we were alerted to concerns about the integrity of the data in the article. A formal investigation was conducted by the Institutional Office for Research Integrity (UIR) at the National Institute for Cancer Research (IST) in Genoa, Italy. The investigation report from the UIR President, dated November 4, 2009, stated the following:
“1) The internal investigation is concluded and no further analyses are planned on the issue.
2) The UIR concluded that the article contains evidence of data fabrication/duplication.
3) All the authors (either belonging or not to the IST) have been informed of the concerns about data integrity. Some authors acknowledged the conclusion stated in the previous point 2, others did not; however, none of them accepted the responsibility of having fabricated the data.”
Based on this report and our concerns about the validity of the study, we hereby retract this article from Cancer and from the medical literature.
Raphael E. Pollock, MD, PhD