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Tongue and tonsil carcinoma
Increasing trends in the U.S. population ages 20–44 years
Version of Record online: 16 MAR 2005
Copyright © 2005 American Cancer Society
Volume 103, Issue 9, pages 1843–1849, 1 May 2005
How to Cite
Shiboski, C. H., Schmidt, B. L. and Jordan, R. C. K. (2005), Tongue and tonsil carcinoma. Cancer, 103: 1843–1849. doi: 10.1002/cncr.20998
- Issue online: 18 APR 2005
- Version of Record online: 16 MAR 2005
- Manuscript Accepted: 30 NOV 2004
- Manuscript Received: 28 SEP 2004
- National Institutes of Health (NIH)/National Institute of Dental and Cranio-Facial Research (NIDCR). Grant Numbers: K23 DE00443, DE14609, PO1DE13904
- NIH/National Cancer Institute. Grant Number: CA095231
- Tobacco-Related Disease Research Program. Grant Numbers: 11RT-0141, 12KT-0166
- oral carcinoma;
- pharyngeal carcinoma;
- tongue carcinoma;
- tonsil carcinoma;
- young adults;
- relative survival
An increasing incidence of oral carcinoma among young adults has been reported in the U.S. and Europe. Although the association between human papillomavirus infection and tonsillar carcinoma is now well established, to the authors' knowledge little is known about incidence trends in tonsillar carcinoma among younger adults. The objective of the current study was to explore the trends in both oral cavity and pharyngeal squamous cell carcinoma (SCC) in younger U.S. populations, in particular tongue and tonsillar SCC.
Using the 1973–2001 Surveillance, Epidemiology and End Results (SEER) database, we computed age, race, and site-specific trends of oral and pharyngeal (excluding nasopharynx) carcinoma incidence rates. The percent change (PC) and annual percent change (APC) were computed to explore trends in incidence rates over time.
There were 2262 SCC of the oral cavity and 1251 SCC of the pharynx reported to the SEER program from 1973 to 2001 in adults aged 20–44 years. There was a statistically significant increase in the incidence of oral tongue SCC (APC = +2.1; P < 0.001), base of tongue SCC (APC = +1.7; P = 0.04), and palatine tonsil SCC (APC = +3.9; P < 0.001) among younger white individuals, whereas the incidence of SCC in all other oral and pharyngeal sites decreased or remained constant.
The increase in tonsil SCC incidence from 1973 to 2001 paralleled the increase in tongue SCC, whereas SCC in all other oral and pharyngeal sites remained constant or decreased. This may suggest similar etiologic factors for SCC affecting the palatine tonsils and tongue in younger populations. Cancer 2005. © 2005 American Cancer Society.