Fax: (215) 349-5445
Similar long-term results of breast-conservation treatment for Stage I and II invasive lobular carcinoma compared with invasive ductal carcinoma of the breast†
The University of Pennsylvania experience
Article first published online: 10 MAY 2005
Copyright © 2005 American Cancer Society
Volume 103, Issue 12, pages 2447–2454, 15 June 2005
How to Cite
Santiago, R. J., Harris, E. E. R., Qin, L., Hwang, W.-T. and Solin, L. J. (2005), Similar long-term results of breast-conservation treatment for Stage I and II invasive lobular carcinoma compared with invasive ductal carcinoma of the breast. Cancer, 103: 2447–2454. doi: 10.1002/cncr.21071
Presented in part at the 45th annual meeting of the American Society for Therapeutic Radiology and Oncology, Salt Lake City, Utah, October 19–23, 2003.
- Issue published online: 2 JUN 2005
- Article first published online: 10 MAY 2005
- Manuscript Accepted: 2 FEB 2005
- Manuscript Revised: 19 JAN 2005
- Manuscript Received: 17 AUG 2004
- The Breast Cancer Research Foundation
- long-term outcomes;
- invasive lobular carcinoma;
- breast-conservation treatment;
- radiation therapy
The objective of the current study was to determine the long-term results of breast-conservation treatment in women with early-stage, invasive lobular carcinoma of the breast.
Between 1977 and 1995, 1093 women with Stage I and II invasive ductal carcinoma of the breast and 55 women with invasive lobular carcinoma of the breast underwent lumpectomy, axillary lymph node dissection, and radiation treatment. Overall, 49% of the women received adjuvant systemic therapy (chemotherapy and/or hormones).
The median age was 52 years for patients in the invasive ductal group and 54 years for patients in the invasive lobular group. The median follow-up was 8.7 years and 10.2 years for patients in the invasive ductal and invasive lobular groups, respectively. A comparison of patients who had invasive lobular carcinoma with patients who had invasive ductal carcinoma showed no difference in the 10-year actuarial rates of overall survival (85% vs. 79%, respectively; P = 0.73), cause-specific survival (93% vs. 84%, respectively; P = 0.85), or freedom from distant metastases (81% vs. 80%, respectively; P = 0.76). The 10-year rates of local failure were 18% for patients with invasive lobular carcinoma and 12% for patients with invasive ductal carcinoma (P = 0.24), and the 10-year rates of contralateral breast carcinoma development for the 2 groups were 12% and 8%, respectively (P = 0.40).
Breast-conservation treatment yielded similar long-term results for women with early-stage, invasive lobular carcinoma and women with the more prevalent invasive ductal carcinoma. Cancer 2005. © 2005 American Cancer Society.