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Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma
Version of Record online: 10 MAY 2005
Copyright © 2005 American Cancer Society
Volume 103, Issue 12, pages 2616–2622, 15 June 2005
How to Cite
Mukherji, S. K., Toledano, A. Y., Beldon, C., Schmalfuss, I. M., Cooper, J. S., Sicks, J. D., Amdur, R., Sailer, S., Loevner, L. A., Kousouboris, P. and Ang, K. (2005), Interobserver reliability of computed tomography-derived primary tumor volume measurement in patients with supraglottic carcinoma. Cancer, 103: 2616–2622. doi: 10.1002/cncr.21072
- Issue online: 2 JUN 2005
- Version of Record online: 10 MAY 2005
- Manuscript Accepted: 2 FEB 2005
- Manuscript Revised: 29 OCT 2004
- Manuscript Received: 23 AUG 2004
- American College of Radiology Imaging Network (ACRIN). Grant Numbers: U01 CA80098, U01 CA79778
- National Cancer Institute (NCI)
- Radiation Therapy Oncology Group (RTOG). Grant Numbers: RTOG-91-11, U10 CA21661, U10 CA37422, U10 CA32115
- National Cancer Institute
- tumor volume;
- squamous cell cancer;
- head and neck;
Prior studies have determined that macroscopic (“gross”) tumor volume (GTV), as calculated from pretreatment computer tomography (CT), was capable of predicting local control in squamous cell carcinoma arising in different subsites in the head and neck in patients who were treated with nonsurgical organ-preservation therapy. The majority of these studies were single-institution, retrospective investigations. Consequently, there has been concern that GTV measurements may not be reproducible by different readers at different institutions. The objective of the current study was to measure the interobserver reliability for GTV measurements for squamous cell carcinoma of the supraglottic larynx (SGSCCA) performed by different readers at different institutions.
Eight experienced readers (4 neuroradiologists and 4 radiation oncologists) from different institutions independently measured the pretreatment GTV of 20 patients with SGSCCA. The CT scans were obtained from patients entered into the definitive radiation therapy arm of Radiation Therapy Oncology Group protocol 91-11, who had supraglottic carcinoma and underwent pretreatment CT scans of the neck. Statistical analysis focused on interobserver reliability as measured by the intraclass correlation coefficient.
The intraclass correlation coefficient was 0.81 (95% lower confidence bound, 0.71). This value was interpreted as “excellent.”
GTV measurements were reliable and reproducible when performed by neuroradiologists and radiation oncologists who were experienced in the interpretation of CT scans of the extracranial head and neck in patients with SGSCCA. The result implied that the correlation between GTV and local control should be reproducible across institutions. Cancer 2005. © 2005 American Cancer Society.