Original Article

You have full text access to this OnlineOpen article

Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma

  1. Robert R. McWilliams M.D.1,†,*,
  2. Kari G. Rabe M.S.2,
  3. Curtis Olswold B.S.2,
  4. Mariza De Andrade Ph.D.2,
  5. Gloria M. Petersen Ph.D.2

Article first published online: 23 MAY 2005

DOI: 10.1002/cncr.21166

Issue

Cancer

Cancer

Volume 104, Issue 2, pages 388–394, 15 July 2005

Additional Information

How to Cite

McWilliams, R. R., Rabe, K. G., Olswold, C., De Andrade, M. and Petersen, G. M. (2005), Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma. Cancer, 104: 388–394. doi: 10.1002/cncr.21166

Author Information

  1. 1

    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota

  2. 2

    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota

  1. †

    Fax: (507) 284-1803

*Department of Oncology, Mayo Clinic College of Medicine, Gonda 10, 200 First Street, SW, Rochester, MN 55905

Publication History

  1. Issue published online: 29 JUN 2005
  2. Article first published online: 23 MAY 2005
  3. Manuscript Accepted: 9 MAR 2005
  4. Manuscript Revised: 2 FEB 2005
  5. Manuscript Received: 27 DEC 2004

Funded by

  • Lustgarten Foundation for Pancreas Cancer Research
  • National Cancer Institute. Grant Number: R01 CA97075
  • Mayo Clinic SPORE in Pancreatic Cancer. Grant Numbers: P20 CA 10270, R25T CA 92049

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (88K)

REFERENCES

  • 1
    Hemminki K, Li X. Familial and second primary pancreatic cancers: a nationwide epidemiologic study from Sweden. Int J Cancer. 2003; 103: 525–530.
    Direct Link:
  • 2
    Jemal A, Tiwari RC, Murray T, et al. Cancer statistics, 2004. CA Cancer J Clin. 2004; 54: 8–29.
    Direct Link:
  • 3
    Brentnall TA. Cancer surveillance of patients from familial pancreatic cancer kindreds. Med Clin North Am. 2000; 84: 707–718.
  • 4
    Murphy KM, Brune KA, Griffin C, et al. Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res 2002; 62: 3789–3793.
  • 5
    Hahn SA, Greenhalf B, Ellis I, et al. BRCA2 germline mutations in familial pancreatic carcinoma [comment]. J Natl Cancer Inst. 2003; 95: 214–221.
  • 6
    Bartsch DK, Sina-Frey M, Lang S, et al. CDKN2A germline mutations in familial pancreatic cancer. Ann Surg. 2002; 236: 730–737.
  • 7
    Klein AP, Beaty TH, Bailey-Wilson JE, Brune KA, Hruban RH, Petersen GM. Evidence for a major gene influencing risk of pancreatic cancer. Genet Epidemiol. 2002; 23: 133–149.
    Direct Link:
  • 8
    Ghadirian P, Lynch HT, Krewski D. Epidemiology of pancreatic cancer: an overview. Cancer Detect Prev. 2003; 27: 87–93.
  • 9
    Ekbom A, McLaughlin JK, Karlsson BM, et al. Pancreatitis and pancreatic cancer: a population-based study. J Natl Cancer Inst. 1994; 86: 625–627.
  • 10
    Peterson GM, de Andrade M, Goggins M, et al. Pancreatic cancer genetic epidemiology (PACGENE) consortium [abstract]. Proceedings of the Lustgarten Foundation for Pancreatic Cancer Research, Boston, MA, 2003: 14.
  • 11
    Kerber RA, Slattery ML. Comparison of self-reported and database-linked family history of cancer data in a case-control study. Am J Epidemiol. 1997; 146: 244–248.
  • 12
    Glanz K, Grove J, Le Marchand L, Gotay C. Underreporting of family history of colon cancer: correlates and implications. Cancer Epidemiol Biomarkers Prev. 1999; 8: 635–639.
  • 13
    National Cancer Institute D, Surveillance Research Program, Cancer Statistics Branch. Surveillance, Epidemiology, and End Results (SEER) Program SEER*Stat Database: Incidence - SEER 9 Regs Public-Use. Available from URL: www.seer.cancer.gov [accessed January 2004].
  • 14
    Lynch HT, Brand RE, Hogg D, et al. Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. Cancer. 2002; 94: 84–96.
    Direct Link:
  • 15
    Park JG, Park YJ, Wijnen JT, Vasen HF. Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing. Int J Cancer. 1999; 82: 516–519.
    Direct Link:
  • 16
    Zhang J, Quan H, Ng J, Stepanavage ME. Some statistical methods for multiple endpoints in clinical trials. Control Clin Trials 1997; 18: 204–221.
  • 17
    Petersen GM, Hruban RH. Familial pancreatic cancer: where are we in 2003? [comment]. J Natl Cancer Inst. 2003; 95: 180–181.
  • 18
    Lowenfels AB, Maisonneuve P. Epidemiologic and etiologic factors of pancreatic cancer. Hematol Oncol Clin North Am. 2002; 16: 1–16.
  • 19
    Lubin JH, Blot WJ. Assessment of lung cancer risk factors by histologic category. J Natl Cancer Inst. 1984; 73: 383–389.
  • 20
    Coughlin SS, Calle EE, Patel AV, Thun MJ. Predictors of pancreatic cancer mortality among a large cohort of United States adults. Cancer Causes Control. 2000; 11: 915–923.
  • 21
    Ghadirian P, Liu G, Gallinger S, et al. Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas. Int J Cancer. 2002; 97: 807–810.
    Direct Link:
  • 22
    Silverman DT, Schiffman M, Everhart J, et al. Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer. 1999; 80: 1830–1837.
  • 23
    Schenk M, Schwartz AG, O'Neal E, et al. Familial risk of pancreatic cancer. J Natl Cancer Inst. 2001; 93: 640–644.
  • 24
    Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004; 96: 261–268.
  • 25
    Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB. Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer [erratum appears in Ann Intern Med 2000;132:419]. Ann Internal Med. 1999; 131: 247–255.
  • 26
    Hruban RH, Canto MI, Yeo CJ. Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer. Dig Dis 2001; 19: 76–84.
  • 27
    Canto MI, Goggins M, Yeo CJ, et al. Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach. Clin Gastroenterol Hepatol. 2004; 2: 606–621.
View Full Article (HTML) Get PDF (88K)