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Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma†
A multiinstitutional, retrospective review of 180 patients
Article first published online: 13 MAY 2005
Copyright © 2005 American Cancer Society
Volume 104, Issue 1, pages 126–134, 1 July 2005
How to Cite
Shikama, N., Ogawa, K., Tanaka, S., Toita, T., Nakamura, K., Uno, T., Ohnishi, H., Itami, J., Tada, T. and Saeki, N. (2005), Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma. Cancer, 104: 126–134. doi: 10.1002/cncr.21169
This study was presented in part at the 45th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Salt Lake City, UT, October 19–23, 2003.
- Issue published online: 17 JUN 2005
- Article first published online: 13 MAY 2005
- Manuscript Accepted: 9 MAR 2005
- Manuscript Revised: 16 FEB 2005
- Manuscript Received: 1 NOV 2004
- Ministry of Health, Labor, and Welfare of Japan. Grant Numbers: 12-13, 16-12
- spinal irradiation
The current study assessed the contribution of spinal irradiation to the treatment outcome of patients with intracranial germinoma.
Clinical data from 180 patients with intracranial germinoma, who were treated with radiotherapy and/or chemotherapy from 1980 to 2001, were collected from 6 institutions. The patients' median age was 16 years (range, 1–47 yrs), and the male-to-female ratio was 133:47. Pathologic verification was obtained in 88 patients. A solitary tumor was seen in 129 patients, and multifocal or disseminated tumors were detected in 51 patients. The median tumor size was 2.5 cm (range, 0.6–7.0 cm). Local field and/or whole brain irradiation was performed in 114 patients, and craniospinal irradiation was performed in 66 patients. Fifty-five patients were treated with chemotherapy. The median follow-up time was 89 months (range, 3–297 mos).
Eight-year overall and event-free survival rates were 91% and 89%, respectively. The 8-year recurrence rates at the primary site, intracranial space, and the spinal space were 1%, 6%, and 6%, respectively. Cox regression analysis showed that spinal irradiation (hazard ratio, 1.050; 95% confidence interval [CI], 0.355–3.170) did not contribute to a favorable event-free survival.
Spinal irradiation did not contribute to favorable event-free survival in patients with intracranial germinoma. Cancer 2005. © 2005 American Cancer Society.