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Original Article
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Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor κB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway
Article first published online: 11 JUL 2005
DOI: 10.1002/cncr.21216
Copyright © 2005 American Cancer Society
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How to Cite
Siwak, D. R., Shishodia, S., Aggarwal, B. B. and Kurzrock, R. (2005), Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor κB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer, 104: 879–890. doi: 10.1002/cncr.21216
Publication History
- Issue published online: 2 AUG 2005
- Article first published online: 11 JUL 2005
- Manuscript Accepted: 14 APR 2005
- Manuscript Revised: 7 MAR 2005
- Manuscript Received: 1 OCT 2004
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- 1, , , , , , , Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy, Cancer Science, 2012, 103, 4Direct Link:
- 2, , , , , , , Evaluationin Vitroof Synthetic Curcumins As Agents Promoting Monocytic Gene Expression Related to β-Amyloid Clearance, Chemical Research in Toxicology, 2012, 25, 1, 101
- 3, , Botanicals for the prevention and treatment of cutaneous melanoma, Pigment Cell & Melanoma Research, 2011, 24, 4Direct Link:
- 4, , , , , , , Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells, International Journal of Cancer, 2011, 128, 4Direct Link:
- 5, , , , Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways, Molecular Biology Reports, 2011, 39, 4, 4803
- 6, , , , Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma, Molecular Cancer, 2011, 10, 1, 12
- 7, , , , , Curcumin's Effect on Intestinal Inflammation and Tumorigenesis in the ApcMin/+Mouse, Journal of Interferon & Cytokine Research, 2011, 31, 2, 219
- 8, , , , , Femtosecond Fluorescence Upconversion Investigations on the Excited-State Photophysics of Curcumin, Australian Journal of Chemistry, 2011, 64, 1, 23
- 9, , , , , , , Inhibition of IκB Kinase β Attenuates Hypoxia-Induced Inflammatory Mediators in Rat Renal Tubular Cells, Transplantation Proceedings, 2011, 43, 5, 1503
- 10, , , , , , , , Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells, European Journal of Pharmacology, 2011, 659, 1, 7
- 11, , , , , , , , Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry, Journal of Chromatography B, 2011, 879, 26, 2751
- 12, , , , , Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer, Genes & Nutrition, 2011, 6, 2, 109
- 13, , Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy, Chinese Medicine, 2011, 6, 1, 31
- 14, , , , , , Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor κB Is a Steady Feature of Urinary Bladder Carcinogenesis, Advances in Urology, 2010, 2010, 1
- 15, Curcumin targeted signaling pathways: basis for anti-photoaging and anti-carcinogenic therapy, International Journal of Dermatology, 2010, 49, 6Direct Link:
- 16, , , , , , , , , Curcuminoids activate p38 MAP kinases and promote UVB-dependent signalling in keratinocytes, Experimental Dermatology, 2010, 19, 6Direct Link:
- 17, , , , , , , , Structure–activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof, Bioorganic & Medicinal Chemistry, 2010, 18, 3, 1083
- 18, , , , , , , , , , Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles, International Journal of Pharmaceutics, 2010, 400, 1-2, 211
- 19, , , , Systematic analysis of the antiproliferative effects of novel and standard anticancer agents in rhabdoid tumor cell lines, Anti-Cancer Drugs, 2010, 21, 5, 514
- 20, , The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation, Biomaterials, 2010, 31, 25, 6597
- 21, , Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells, Journal of Ethnopharmacology, 2009, 122, 2, 294
- 22, , , Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?, The AAPS Journal, 2009, 11, 3, 495
- 23, , , , , Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells, European Journal of Immunology, 2009, 39, 11Direct Link:
- 24, , , , , , , , Curcumin Modulates the Radiosensitivity of Colorectal Cancer Cells by Suppressing Constitutive and Inducible NF-κB Activity, International Journal of Radiation Oncology*Biology*Physics, 2009, 75, 2, 534
- 25, , , , , , , , Curcumin: A potential radio-enhancer in head and neck cancer, The Laryngoscope, 2009, 119, 10Direct Link:
- 26, , , , , , , , Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits, Journal of the American Chemical Society, 2009, 131, 42, 15257
- 27, , , , , , Evidence ofγ-Tocotrienol as an Apoptosis-Inducing, Invasion-Suppressing, and Chemotherapy Drug-Sensitizing Agent in Human Melanoma Cells, Nutrition and Cancer, 2009, 61, 3, 357
- 28, , Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells, Molecular and Cellular Biochemistry, 2009, 325, 1-2, 107
- 29, , Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases, The International Journal of Biochemistry & Cell Biology, 2009, 41, 1, 40
- 30, Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities, Antioxidants & Redox Signaling, 2009, 11, 12, 3013
- 31, , , , , Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1β gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells, Toxicology and Applied Pharmacology, 2009, 240, 1, 15
- 32, , , , , , , Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: Effect on matrix metalloproteinases, Bioorganic & Medicinal Chemistry, 2009, 17, 3, 1290
- 33, , , , , , , The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth, Free Radical Biology and Medicine, 2009, 46, 2, 220
- 34
- 35, Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent, Molecular Nutrition & Food Research, 2008, 52, S1Direct Link:
- 36, , , Cell Cycle Checkpoint Models for Cellular Pharmacology of Paclitaxel and Platinum Drugs, The AAPS Journal, 2008, 10, 1, 15
- 37, , Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation, Life Sciences, 2008, 82, 3-4, 182
- 38, , Immunomodulatory effects of curcumin in allergy, Molecular Nutrition & Food Research, 2008, 52, 9Direct Link:
- 39, , , , , , Micelles of poly(ethylene oxide)-b-poly(ε-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin, Journal of Biomedical Materials Research Part A, 2008, 86A, 2Direct Link:
- 40, , , , , Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells, Biochemical Pharmacology, 2008, 76, 11, 1340
- 41, , , Multi-targeted therapy by curcumin: how spicy is it?, Molecular Nutrition & Food Research, 2008, 52, 9Direct Link:
- 42, , “Spicing Up†of the Immune System by Curcumin, Journal of Clinical Immunology, 2007, 27, 1, 19
- 43, , , , Back to basics: how natural products can provide the basis for new therapeutics, Expert Opinion on Investigational Drugs, 2007, 16, 11, 1753
- 44, , , , , , Coordinated Upregulation of COX-2 and NF-κB Is a Steady Feature of Laryngeal Carcinogenesis, ORL, 2007, 69, 3, 181
- 45, , , , , , , , , , , Curcumin downregulates the constitutive activity of NF-κB and induces apoptosis in novel mouse melanoma cells, Melanoma Research, 2007, 17, 5, 274
- 46, , , , , , Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines, Biochemical Pharmacology, 2007, 73, 7, 1024
- 47, , , Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells, Gynecologic Oncology, 2007, 104, 2, 443
- 48, , , , , , Delayed activation of PKCδ and NFκB and higher radioprotection in splenic lymphocytes by copper (II)–Curcumin (1:1) complex as compared to curcumin, Journal of Cellular Biochemistry, 2007, 102, 5Direct Link:
- 49
- 50
- 51, , , , , Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor κB1 and mitogen-activated protein kinase pathways, FEBS Journal, 2006, 273, 16Direct Link:
- 52, Apoptosis and melanoma: how new insights are effecting the development of new therapies for melanoma, Current Opinion in Oncology, 2006, 18, 2, 189
- 53, , , , , Curcumin down regulates smokeless tobacco-induced NF-κB activation and COX-2 expression in human oral premalignant and cancer cells, Toxicology, 2006, 228, 1, 1
- 54, , , , , , , , , From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer, Expert Opinion on Therapeutic Targets, 2006, 10, 1, 87
- 55, , , , , , Mechanisms of Curcumin- and EGF-Receptor Related Protein (ERRP)-Dependent Growth Inhibition of Colon Cancer Cells, Nutrition and Cancer, 2006, 55, 2, 185
- 56, , , , , , , Molecular spectrum of pigmented skin lesions: from nevus to melanoma, Expert Review of Dermatology, 2006, 1, 5, 679
- 57, , NF-κB activation in melanoma, Pigment Cell Research, 2006, 19, 2Direct Link:
- 58
- 59
- 60
- 61, , , Les aliments traditionnels : remèdes de bonne femme ou pharmacopée du xxie siècle l’exemple de la curcumine, Cahiers de Nutrition et de Diététique, 2005, 40, 6, 325