Original Article

You have full text access to this OnlineOpen article

Intensity-modulated radiation therapy use in the U.S., 2004

  1. Loren K. Mell M.D.†,*,
  2. Amit K. Mehrotra B.S.,
  3. Arno J. Mundt M.D.

Article first published online: 2 AUG 2005

DOI: 10.1002/cncr.21284

Issue

Cancer

Cancer

Volume 104, Issue 6, pages 1296–1303, 15 September 2005

Additional Information

How to Cite

Mell, L. K., Mehrotra, A. K. and Mundt, A. J. (2005), Intensity-modulated radiation therapy use in the U.S., 2004. Cancer, 104: 1296–1303. doi: 10.1002/cncr.21284

Author Information

  1. Department of Radiation and Cellular Oncology, University of Chicago and University of Illinois at Chicago, Chicago, Illinois

  1. †

    Fax: (773) 834-7340

*Department of Radiation and Cellular Oncology, University of Chicago Hospitals, 5758 S. Maryland Avenue/MC 9006, Chicago, IL 60637

Publication History

  1. Issue published online: 31 AUG 2005
  2. Article first published online: 2 AUG 2005
  3. Manuscript Accepted: 25 APR 2005
  4. Manuscript Revised: 16 MAR 2005
  5. Manuscript Received: 9 FEB 2005

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (119K)

REFERENCES

  • 1
    Leibel SA, Fuks Z, Zelefsky MJ, et al. Intensity-modulated radiotherapy. Cancer J. 2002; 8: 164–176.
  • 2
    Xia P, Fu KK, Wong GW, Akazawa C, Verhey LJ. Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2000; 48: 329–337.
  • 3
    Kestin LL, Sharpe MB, Frazier RC, et al. Intensity modulation to improve dose uniformity with tangential breast radiotherapy: initial clinical experience. Int J Radiat Oncol Biol Phys. 2000; 48: 1559–1568.
  • 4
    Liu HH, Wang X, Dong L, et al. Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2004; 58: 1268–1279.
  • 5
    Roeske JC, Lujan A, Rotmensch J, Waggoner SE, Yamada D, Mundt AJ. Intensity-modulated whole pelvic radiation therapy in patients with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2000; 48: 1613–1621.
  • 6
    Lujan AE, Mundt AJ, Yamada SD, Rotmensch J, Roeske JC. Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy. Int J Radiat Oncol Biol Phys. 2003; 57: 516–521.
  • 7
    Murshed H, Liu HH, Liao Z, et al. Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2004; 58: 1258–1267.
  • 8
    Ahmed RS, Kim RY, Duan J, Meleth S, De Los Santos JF, Fiveash JB. IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk. Int J Radiat Oncol Biol Phys. 2004; 60: 505–512.
  • 9
    Nutting CM, Corbishley CM, Sanchez-Nieto B, Cosgrove VP, Webb S, Dearnaley DP. Potential improvements in the therapeutic ratio for prostate cancer irradiation: dose escalation of pathologically identified tumour nodules using intensity modulated radiotherapy. Br J Radiol. 2002; 75: 151–161.
  • 10
    Huang E, Teh BS, Strother DR, et al. Intensity-modulated radiation therapy for pediatric medulloblastoma: early report on the reduction of ototoxicity. Int J Radiat Oncol Biol Phys. 2002; 52: 599–605.
  • 11
    Uy NW, Woo SY, Teh BS, et al. Intensity-modulated radiation therapy (IMRT) for meningioma. Int J Radiat Oncol Biol Phys. 2002; 53: 1265–1270.
  • 12
    Eisbruch A, Kim HM, Terrell JE, Marsh LH, Dawson LA, Ship JA. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001; 50: 695–704.
  • 13
    Chao KS, Majhail N, Huang CJ, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol. 2001; 61: 275–280.
  • 14
    Vicini FA, Sharpe M, Kestin L, et al. Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2002; 54: 1336–1344.
  • 15
    Mundt AJ, Mell LK, Roeske JC. Preliminary analysis of chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy. Int J Radiat Oncol Biol Phys. 2003; 56: 1354–1360.
  • 16
    Hong L, Alektiar KM, Hunt M, Venkatraman E, Leibel SA. Intensity-modulated radiotherapy for soft tissue sarcoma of the thigh. Int J Radiat Oncol Biol Phys. 2004; 59: 752–759.
  • 17
    Milano MT, Chmura SJ, Garofalo MC, et al. Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys. 2004; 59: 445–453.
  • 18
    Zelefsky MJ, Fuks Z, Hunt M, et al. High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys. 2002; 53: 1111–1116.
  • 19
    Kupelian PA, Reddy CA, Carlson TP, Altsman KA, Willoughby TR. Preliminary observations on biochemical relapse-free survival rates after short-course intensity-modulated radiotherapy (70 Gy at 2.5 Gy/fraction) for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2002; 53: 904–912.
  • 20
    Pirzkall A, Debus J, Haering P, et al. Intensity modulated radiotherapy (IMRT) for recurrent, residual, or untreated skull-base meningiomas: preliminary clinical experience. Int J Radiat Oncol Biol Phys. 2003; 55: 362–372.
  • 21
    Dawson LA, Anzai Y, Marsh L, et al. Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 2000; 46: 1117–1126.
  • 22
    Forster KM, Smythe WR, Starkschall G, et al. Intensity modulated radiation therapy following extrapleural pneumonectomy for the treatment of malignant mesothelioma: clinical implementation. Int J Radiat Oncol Biol Phys. 2003; 55: 606–616.
  • 23
    Knab BR, Roeske JC, Mehta N, et al. Outcome of endometrial cancer patients treated with adjuvant intensity modulated pelvic radiation therapy [abstract]. Int J Radiat Oncol Biol Phys. 2004; 60(Suppl 1): S303.
  • 24
    Milker-Zabel S, Zabel A, Thilmann C, Schlegel W, Wannenmacher M, Debus J. Clinical results of retreatment of vertebral bone metastases by stereotactic conformal radiotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2003; 55: 162–167.
  • 25
    Lu TX, Mai WY, Teh BS, et al. Initial experience using intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2004; 58: 682–687.
  • 26
    Gregoire V, Levendag P, Ang KK, et al. CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines. Radiother Oncol. 2003; 69: 227–236.
  • 27
    Mell LK, Fyles A, Small W, et al. Adjuvant intensity modulated pelvic radiation therapy in gynecologic malignancies: survey of the Gynecologic IMRT Working Group [abstract]. Int J Radiat Oncol Biol Phys. 2004; 60: S215–S216.
  • 28
    Gierga DP, Chen GT, Kung JH, Betke M, Lombardi J, Willett CG. Quantification of respiration-induced abdominal tumor motion and its impact on IMRT dose distributions. Int J Radiat Oncol Biol Phys. 2004; 58: 1584–1595.
  • 29
    Konski AA, Watkins-Bruner D, Feigenburg S, et al. Intensity modulated radiation therapy (IMRT) is a cost effective treatment for intermediate risk prostate cancer [abstract]. Int J Radiat Oncol Biol Phys. 2004; 60(Suppl 1): S144.
  • 30
    Hall EJ, Wuu CS. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys. 2003; 56: 83–88.
  • 31
    Mell LK, Roeske JC, Mundt AJ. A survey of intensity modulated radiation therapy use in the United States. Cancer. 2003; 98: 204–211.
    Direct Link:
  • 32
    Brick JM, Kalton G. Handling missing data in survey research. Stat Methods Med Res. 1996; 5: 215–238.
  • 33
    Chao KS, Ozyigit G, Tran BN, Cengiz M, Dempsey JF, Low DA. Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2003; 55: 312–321.
  • 34
    Brixey CJ, Roeske JC, Lujan AE, Yamada SD, Rotmensch J, Mundt AJ. Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys. 2002; 54: 1388–1396.
  • 35
    Szerlag C, Canovas L. Billing and reimbursement issues. In: MundtAJ, RoeskeJC, editors. Intensity modulated radiation therapy: a clinical perspective. Toronto: BC Decker, 2005: 214–229.
  • 36
    Brown E. “ Cancer in the crosshairs.” Forbes. 2002; 170: 361–364.
  • 37
    Schomas D, Milano M, Roeske JC, Mell LK, Mundt AJ. Intensity modulated radiation therapy and the Internet: evaluation of the content and quality of patient-oriented information. Cancer. 2004; 101: 412–420.
    Direct Link:
  • 38
    Chmura SJ, Garofalo M, Salama J, et al. Does the dose protraction inherent to IMRT decrease tumor cell killing in vitro [abstract]? Int J Radiat Oncol Biol Phys. 2004; 60(Suppl 1): 1107.
  • 39
    Intensity Modulated Radiation Therapy Collaborative Working Group. Intensity-modulated radiotherapy: current status and issues of interest. Int J Radiat Oncol Biol Phys. 2002; 51: 880–914.
  • 40
    Malik R, Oh JL, Roeske JC, et al. Resident education in intensity modulated radiation therapy (IMRT) [abstract]. Int J Radiat Oncol Biol Phys. 2004; 60(Suppl 1): S146.
View Full Article (HTML) Get PDF (119K)