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The effect of changes in tumor size on breast carcinoma survival in the U.S.: 1975–1999†

  1. Elena B. Elkin Ph.D.1,‡,*,
  2. Clifford Hudis M.D.2,
  3. Colin B. Begg Ph.D.1,
  4. Deborah Schrag M.D., M.P.H.1,2

Article first published online: 8 AUG 2005

DOI: 10.1002/cncr.21285

Issue

Cancer

Cancer

Volume 104, Issue 6, pages 1149–1157, 15 September 2005

Additional Information

How to Cite

Elkin, E. B., Hudis, C., Begg, C. B. and Schrag, D. (2005), The effect of changes in tumor size on breast carcinoma survival in the U.S.: 1975–1999. Cancer, 104: 1149–1157. doi: 10.1002/cncr.21285

Author Information

  1. 1

    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York

  2. 2

    Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York

  1. ‡

    Fax: (646) 735-0011

*Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 44, New York, NY 10021

  1. †

    Presented in part at the 40th Annual Meeting of the American Society for Clinical Oncology, New Orleans, Louisiana, June 5–8, 2004.

Publication History

  1. Issue published online: 31 AUG 2005
  2. Article first published online: 8 AUG 2005
  3. Manuscript Accepted: 26 APR 2005
  4. Manuscript Revised: 15 APR 2005
  5. Manuscript Received: 14 FEB 2005

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Keywords:

  • breast carcinoma;
  • survival;
  • relative survival;
  • tumor size;
  • trends

Over the past 30 years, the distribution of incident breast carcinoma cases in the U.S. has shifted toward smaller tumors, even within conventional stage categories. A substantial proportion of the improvement noted in breast carcinoma survival can be attributed to this within-stage migration of tumor size. Standardizing survival estimates on the basis of tumor size improves the understanding of secular trends in breast carcinoma outcomes.

Abstract

BACKGROUND

Temporal comparisons of case survival are commonly used to assess improvement in cancer treatment at the population level. However, such comparisons may be confounded by secular trends in disease prognosis, even within conventional stage categories. The objective of the current study was to characterize within-stage migration of tumor size in breast carcinoma, and to estimate the effect of this shift on reported breast carcinoma survival.

METHODS

Population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data were used to evaluate secular trends in tumor size at the time of diagnosis and relative survival among localized and regional invasive breast carcinoma patients diagnosed between 1975–1999. Outcomes were stage-specific tumor size distribution, 5-year relative survival, relative survival standardized to the tumor size distribution of the cohort diagnosed between 1975–1979, and the percentage of improvement in relative survival attributable to shifts in tumor size distribution.

RESULTS

Within each stage category, the proportion of smaller tumors increased significantly over time. Comparing patients diagnosed between 1995–1999 with those diagnosed between 1975–1979, within-stage migration of tumor size accounted for 61% and 28%, respectively, of the relative survival increases noted in localized and regional breast carcinoma.

CONCLUSIONS

The tumor size distribution of incident breast carcinomas in SEER has shifted toward smaller tumors. A substantial fraction of the improvement in breast carcinoma survival noted since 1975 may be attributable to within-stage migration of tumor size. Cancer 2005. © 2005 American Cancer Society.

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