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First analysis of patient demographics, technical reproducibility, cosmesis, and early toxicity†

Results of the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial

  1. Frank A. Vicini M.D.1,¶,*,
  2. Peter D. Beitsch M.D.2,
  3. Coral A. Quiet M.D.3,
  4. Angela Keleher M.D.4,
  5. Delia Garcia M.D.5,
  6. Howard C. Snider M.D.6,
  7. Mark A. Gittleman M.D.7,
  8. Victor J. Zannis M.D.8,
  9. H. Kuerer M.D.9,
  10. Eric B. Whitacre M.D.10,
  11. Pat W. Whitworth M.D.11,
  12. Richard E. Fine M.D.12,‡,
  13. Bruce G. Haffty M.D.13,§,
  14. L. Stacey Arrambide M.S., B.S.14

Article first published online: 8 AUG 2005

DOI: 10.1002/cncr.21289

Issue

Cancer

Cancer

Volume 104, Issue 6, pages 1138–1148, 15 September 2005

Additional Information

How to Cite

Vicini, F. A., Beitsch, P. D., Quiet, C. A., Keleher, A., Garcia, D., Snider, H. C., Gittleman, M. A., Zannis, V. J., Kuerer, H., Whitacre, E. B., Whitworth, P. W., Fine, R. E., Haffty, B. G. and Arrambide, L. S. (2005), First analysis of patient demographics, technical reproducibility, cosmesis, and early toxicity. Cancer, 104: 1138–1148. doi: 10.1002/cncr.21289

Author Information

  1. 1

    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan

  2. 2

    Allen Comprehensive Breast Center, Allen, Texas

  3. 3

    Department of Radiation Oncology, Arizona Oncology Services, Phoenix, Arizona

  4. 4

    Surgical Breast Disease Program, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania

  5. 5

    Department of Radiation Oncology, St. Louis Cancer an d Breast Center, St. Louis, Missouri

  6. 6

    Alabama Breast Center, Montgomery, Alabama

  7. 7

    Department of Surgery, Sacred Heart Hospital, Allentown, Pennsylvania

  8. 8

    Breast Care Center of the Southwest, Phoenix, Arizona

  9. 9

    Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  10. 10

    The Breast Center of Southern Arizona, Tucson, Arizona

  11. 11

    Nashville Breast Center, Nashville, Tennessee

  12. 12

    The Breast Center, Marietta, Georgia

  13. 13

    Department of Therapeutic Radiology, Yale University, New Haven, Connecticut

  14. 14

    Synergos, Inc. The Woodlands, Texas

  1. ‡

    Advanced Breast Care, Marietta, Georgia

  2. §

    Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, New Jersey

  1. Fax: (248) 551-0089

*Department of Radiation Oncology, Beaumont Cancer Institute, William Beaumont Hospital, 3601 West 13 Mile Road, Royal Oak, MI 48072

  1. †

    Presented, in part, at the 27th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, December 8–11, 2004.

Publication History

  1. Issue published online: 31 AUG 2005
  2. Article first published online: 8 AUG 2005
  3. Manuscript Accepted: 17 MAY 2005
  4. Manuscript Revised: 11 MAY 2005
  5. Manuscript Received: 25 MAR 2005

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REFERENCES

  • 1
    Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002; 347: 1227–1232.
  • 2
    Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002; 347: 1233–1241.
  • 3
    Rosen PP, Fracchia AA, Urban JA, et al. “Residual” mammary carcinoma following simulated partial mastectomy. Cancer. 1975; 35: 739–747.
    Direct Link:
  • 4
    Keisch M, Vicini F, Kuske RR, et al. Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2003; 55: 289–293.
  • 5
    Arthur D, Vicini F, Kuske RR, et al. Accelerated partial breast irradiation: an updated report from the American Brachytherapy Society. Brachytherapy. 2002; 1: 184–190.
  • 6
    Vicini F, Baglan K, Kestin L, et al. The emerging role of brachytherapy in the management of patients with breast cancer. Semin Radiat Oncol. 2002; 12: 31–39.
  • 7
    Rose MA, Olivotto I, Cady B, et al. Conservative surgery and radiation therapy for early breast cancer. Long-term cosmetic results. Arch Surg. 1989; 124: 153–157.
  • 8
    Vicini FA, Kestin L, Chen P, et al. Limited-field radiation therapy in the management of early-stage breast cancer. J Natl Cancer Inst. 2003; 95: 1205–1210.
  • 9
    Baglan KL, Martinez AA, Frazier RC, et al. The use of high-dose-rate brachytherapy alone after lumpectomy in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2001; 50: 1003–1011.
  • 10
    Vicini FA, Baglan KL, Kestin LL, et al. Accelerated treatment of breast cancer. J Clin Oncol. 2001; 19: 1993–2001.
  • 11
    Polgar C, Sulyok Z, Fodor J, et al. Sole brachytherapy of the tumor bed after conservative surgery for T1 breast cancer: five-year results of a Phase I–II study and initial findings of a randomized Phase III trial. J Surg Oncol. 2002; 80: 121–128.
    Direct Link:
  • 12
    King TA, Bolton JS, Kuske RR, et al. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) breast cancer. Am J Surg. 2000; 180: 299–304.
  • 13
    Fentiman IS, Poole C, Tong D, et al. Iridium implant treatment without external radiotherapy for operable breast cancer: a pilot study. Eur J Cancer. 1991; 27: 447–450.
  • 14
    Fentiman IS, Poole C, Tong D, et al. Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer. 1996; 32A: 608–611.
  • 15
    Kuske RR. Breast brachytherapy. Hematol Oncol Clin North Am. 1999; 13: 543–vii.
  • 16
    Wazer DE, Lowther D, Boyle T, et al. Clinically evident fat necrosis in women treated with high-dose-rate brachytherapy alone for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2001; 50: 107–111.
  • 17
    Cionini L, Pacini P, Marzano S. Exclusive brachytherapy after conservative surgery in cancer of the breast [abstract]. Lyon Chir. 1993; 89: 128.
  • 18
    Krishnan L, Jewell WR, Tawfik OW, et al. Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with Stage I breast cancer. Breast J. 2001; 7: 91–96.
    Direct Link:
  • 19
    Wazer DE, Berle L, Graham R, et al. Preliminary results of a Phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer. Int J Radiat Oncol Biol Phys. 2002; 53: 889–897.
  • 20
    Vicini FA, Remouchamps V, Wallace M, et al. Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2003; 57: 1247–1253.
  • 21
    Formenti SC, Truong MT, Goldberg JD, et al. Prone accelerated partial breast irradiation after breast-conserving surgery: preliminary clinical results and dose-volume histogram analysis. Int J Radiat Oncol Biol Phys. 2004; 60: 493–504.
  • 22
    Orecchia R, Ciocca M, Lazzari R, et al. Intraoperative radiation therapy with electrons (ELIOT) in early-stage breast cancer. Breast. 2003; 12: 483–490.
  • 23
    Polgar C, Major T, Fodor J, et al. High-dose-rate brachytherapy alone versus whole breast radiotherapy with or without tumor bed boost after breast-conserving surgery: seven-year results of a comparative study. Int J Radiat Oncol Biol Phys. 2004; 60: 1173–1181.
  • 24
    Benitez PR, Chen PY, Vicini FA, et al. Partial breast irradiation in breast conserving therapy by way of interstitial brachytherapy. Am J Surg. 2004; 188: 355–364.
  • 25
    Platt R, Zucker JR, Zaleznik DF, et al. Prophylaxis against wound infection following herniorrhaphy or breast surgery. J Infect Dis. 1992; 166: 556–560.
  • 26
    Keidan RD, Hoffman JP, Weese JL, et al. Delayed breast abscesses after lumpectomy and radiation therapy. Am Surg. 1990; 56: 440–444.
  • 27
    Richards GM, Berson AM, Rescigno J, et al. Acute toxicity of high-dose-rate intracavitary brachytherapy with the MammoSite applicator in patients with early-stage breast cancer. Ann Surg Oncol. 2004; 11: 739–746.
  • 28
    Gittleman MA, Vigneri PM, Carlson DJ, et al. Clinical evaluation of the MammoSite breast brachytherapy catheter: an analysis of technical reproducibility, acute toxicity and patient demographics [abstract]. Int J Radiat Oncol Biol Phys. 2003; 57(Supp): S365.
  • 29
    Shah NM, Tenenholz T, Arthur D, et al. MammoSite and interstitial brachytherapy for accelerated partial breast irradiation: factors that affect toxicity and cosmesis. Cancer. 2004; 101: 727–734.
    Direct Link:
  • 30
    Zannis VJ, Walker LC, Barclay-White B, et al. Postoperative ultrasound-guided percutaneous placement of a new breast brachytherapy balloon catheter. Am J Surg. 2003; 186: 383–385.
  • 31
    Dowlatshahi K, Snider HC, Gittleman MA, et al. Early experience with balloon brachytherapy for breast cancer. Arch Surg. 2004; 139: 603–607.
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