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Prognostic significance of the lymphocyte-to-neutrophil ratio in percutaneous fine-needle aspiration biopsy specimens of advanced nonsmall cell lung carcinoma
Article first published online: 26 JUL 2005
DOI: 10.1002/cncr.21290
Copyright © 2005 American Cancer Society
Additional Information
How to Cite
Nakahara, Y., Mochiduki, Y., Miyamoto, Y., Nakahara, Y. and Katsura, Y. (2005), Prognostic significance of the lymphocyte-to-neutrophil ratio in percutaneous fine-needle aspiration biopsy specimens of advanced nonsmall cell lung carcinoma. Cancer, 104: 1271–1280. doi: 10.1002/cncr.21290
Publication History
- Issue published online: 31 AUG 2005
- Article first published online: 26 JUL 2005
- Manuscript Accepted: 25 APR 2005
- Manuscript Revised: 2 APR 2005
- Manuscript Received: 1 FEB 2005
REFERENCES
- 1, , , . Prognostic significance of histologic host response in cancer of the large bowel. Cancer. 1981; 47: 930–936.Direct Link:
- 2, , , , , . In situ quantitation of inflammatory mononuclear cells in ductal infiltrating breast carcinoma. Relation to prognostic parameters. Am J Pathol. 1987; 128: 52–60.
- 3, , , , . Tumour infiltrating lymphocytes as an independent prognostic factor in transitional cell bladder cancer. Eur J Cancer. 1992; 29A: 69–75.
- 4, , , et al. Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration. Br J Cancer. 1996; 74: 766–772.
- 5, , , , , . Morphometric and morphologic evaluations in stage III non-small cell lung cancers. Prognostic significance of quantitative assessment of infiltrating lymphoid cells. Cancer. 1989; 63: 309–316.Direct Link:
- 6, , , , , . Host defense and survival in patients with lung carcinoma. Cancer. 2000; 89: 2038–2045.Direct Link:
- 7, , , et al. Immune cell infiltrates and prognosis in primary carcinoma of the lung. Lung Cancer. 2000; 27: 27–35.
- 8, , . A high number of tumor-infiltrating lymphocytes are associated with a small tumor size, low tumor stage, and a favorable prognosis in operated small cell lung carcinoma. Clin Cancer Res. 2000; 6: 1875–1881.
- 9SobinLH, WittekindC, editors. TNM classification of malignant tumors, 5th ed. New York: John Wiley & Sons, 1997.
- 10, , . Structural representations of tumor-host relationships in mammary carcinoma. Biologic and prognostic significance. Am J Clin Pathol. 1956; 26: 250–265.
- 11, . The prognostic value of the aspiration biopsy smear in mammary carcinoma. Acta Cytol. 1976; 20: 479–485.
- 12, , , , . Prognostic factors in non-small cell lung cancer: a consensus report. Lung Cancer. 1991; 7: 3–5.
- 13, , , . The value of morphometry to classic prognosticators in breast cancer. Cancer. 1985; 56: 374–382.Direct Link:
- 14, , , . Prognostic value of histopathologic parameters in squamous cell carcinoma of the oropharynx. Cancer. 1984; 54: 2995–3001.Direct Link:
- 15, . Mitotic index in carcinoma of the lung. Lancet. 1979; 2: 852.
- 16, , . Quantitative microscopy of epidermoid lung carcinoma: correlation with survival time. J Natl Cancer Inst. 1976; 56: 463–469.
- 17, , , , . Usefulness of morphometric evaluation of histopathologic slides in predicting long-term outcome of patients with squamous cell carcinoma of the lung. A preliminary report. Chest. 1995; 107: 614–620.
- 18, , , et al. Mitotic index does not predict prognosis in stage IA non-small cell lung cancer. Lung Cancer. 2002; 38: 163–167.
- 19, , , , . Absence of correlation between nuclear morphometry and survival in stage I non-small cell lung carcinoma. Cancer. 1992; 69: 2454–2457.Direct Link:
- 20. The mitotic index in bronchogenic carcinoma. Am Rev Respir Dis. 1971; 104: 536–543.
- 21, , , et al. Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration. Br J Cancer. 1996; 74: 766–772.
- 22, , . Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma. Clin Cancer Res. 1998; 4: 1483–1487.
- 23, , , et al. Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: a prospective study. J Natl Cancer Inst. 1997; 89: 881–886.
- 24, , , . Immunohistochemical study with monoclonal antibodies on immune response in human lung cancers. Cancer Res. 1983; 43: 5883–5889.
- 25, , . Dissemination of cancer cells by needle biopsy of the lung. J Thorac Cardiovasc Surg. 1972; 63: 430–432.
- 26, , , , . Chest wall implantation of lung cancer after thin-needle aspiration biopsy. Ann Thorac Surg. 1989; 48: 284–286.
- 27, , , . Implantation metastasis caused by fine needle aspiration biopsy following curative resection of stage IB non-small cell lung cancer. Eur J Cardiothorac Surg. 2001; 20: 868–870.
- 28, , . Pleural cytologies in lung cancer without pleural effusions. Ann Thorac Surg. 1997; 64: 941–944.
- 29, , , . Operable non-small cell lung cancer diagnosed by transpleural techniques: do they affect relapse and prognosis? Chest. 2001; 120: 1595–1598.

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