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Anaplastic large cell lymphoma treated with a leukemia-like therapy
Report of the Italian Association of Pediatric Hematology and Oncology (AIEOP) LNH-92 protocol
Article first published online: 6 OCT 2005
Copyright © 2005 American Cancer Society
Volume 104, Issue 10, pages 2133–2140, 15 November 2005
How to Cite
Rosolen, A., Pillon, M., Garaventa, A., Burnelli, R., d'Amore, E. S., Giuliano, M., Comis, M., Cesaro, S., Tettoni, K., Luisa Moleti, M., Tamaro, P., Visintin, G. and Zanesco, L. (2005), Anaplastic large cell lymphoma treated with a leukemia-like therapy. Cancer, 104: 2133–2140. doi: 10.1002/cncr.21438
- Issue published online: 31 OCT 2005
- Article first published online: 6 OCT 2005
- Manuscript Accepted: 14 JUN 2005
- Manuscript Revised: 24 MAY 2005
- Manuscript Received: 7 APR 2005
- Fondazione Città della Speranza
- Associazione Italiana contro le Leucemie (AIL)
- anaplastic large cell lymphoma;
Childhood anaplastic large cell lymphoma (ALCL) is a well defined entity with a rather poor prognosis. Different approaches have been adopted in the treatment of ALCL in various cooperative trials, including short high-dose intensive therapy and leukemia-like protocols. In the early 1990s, the Italian Association of Pediatric Hematology and Oncology (AIEOP) initiated a multicenter trial for the treatment of ALCL based on a modified LSA2-L2 protocol.
Thirty-four consecutive eligible children with newly diagnosed ALCL were enrolled in the AIEOP LNH-92 protocol. Treatment was comprised of an induction of remission phase, followed by consolidation and maintenance for a total duration of 24 months, independently of disease stage.
Thirty of 34 patients (88%) achieved complete disease remission and 8 patients experienced disease recurrence. With a median follow-up of 8.4 years, the probabilities of survival and event-free survival were 85% (range, 79–91%) and 65% (range, 57–73%), respectively. Therapy was well tolerated and hematologic toxicity was the most frequent toxicity.
The leukemia-like protocol AIEOP LNH-92 was found to be an effective treatment for childhood ALCL. Its long duration may be beneficial to specific patient subgroups, but optimal treatment duration in ALCL remains to be elucidated. Cancer 2005. © 2005 American Cancer Society.