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Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma
Article first published online: 20 DEC 2005
Copyright © 2005 American Cancer Society
Volume 106, Issue 3, pages 589–598, 1 February 2006
How to Cite
Engelen, M. J. A., Kos, H. E., Willemse, P. H. B., Aalders, J. G., de Vries, E. G. E., Schaapveld, M., Otter, R. and van der Zee, A. G. J. (2006), Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma. Cancer, 106: 589–598. doi: 10.1002/cncr.21616
- Issue published online: 20 JAN 2006
- Article first published online: 20 DEC 2005
- Manuscript Accepted: 16 AUG 2005
- Manuscript Revised: 31 JUL 2005
- Manuscript Received: 8 APR 2005
- Comprehensive Cancer Center North Netherlands
- general gynecologist;
- gynecologic oncologist;
- gynecologic carcinoma;
- medical oncologist;
- patterns of care;
- primary surgery
Consultant gynecologic oncologists from the regional Comprehensive Cancer Center assisted community gynecologists in the surgical treatment of patients with ovarian carcinoma when they were invited. For this report, the authors evaluated the effects of primary surgery by a gynecologic oncologist on treatment outcome.
The hospital files from 680 patients with epithelial ovarian carcinoma who were diagnosed between 1994 and 1997 in the northern part of the Netherlands were abstracted. Treatment results were analyzed according to the operating physician's education by using survival curves and univariate and multivariate Cox regression analyses.
Primary surgery was performed on 184 patients by gynecologic oncologists, and on 328 patients by general gynecologists. Gynecologic oncologists followed surgical guidelines more strictly compared with general gynecologists (patients with International Federation of Gynecology and Obstetrics [FIGO] Stage I–II disease, 55% vs. 33% [P = 0.01]; patients with FIGO Stage III disease, 60% vs. 40% [P = 0.003]) and more often removed all macroscopic tumor in patients with FIGO Stage III disease (24% vs. 12%; P = 0.02). When patients were stratified according to FIGO stage, the 5-year overall survival rate was 86% versus 70% (P = 0.03) for patients with Stage I–II disease and 21% versus 13% (P = 0.02) for patients with Stage III–IV disease who underwent surgery by gynecologic oncologists and general gynecologists, respectively. The hazards ratio for patients who underwent surgery by gynecologic oncologists was 0.79 (95% confidence interval [95%CI], 0.61–1.03; adjusted for patient age, disease stage, type of hospital, and chemotherapy); when patients age 75 years and older were excluded, the hazards ratio fell to 0.71 (95% CI, 0.54–0.94) in multivariate analysis.
The surgical treatment of patients with ovarian carcinoma by gynecologic oncologists occurred more often according to surgical guidelines, tumor removal more often was complete, and survival was improved. Cancer 2006. © 2005 American Cancer Society.