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Original Article
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The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment
A pilot study
Article first published online: 6 JAN 2006
DOI: 10.1002/cncr.21667
Copyright © 2006 American Cancer Society
Additional Information
How to Cite
Mizuta, T., Ozaki, I., Eguchi, Y., Yasutake, T., Kawazoe, S., Fujimoto, K. and Yamamoto, K. (2006), The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment. Cancer, 106: 867–872. doi: 10.1002/cncr.21667
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Publication History
- Issue published online: 3 FEB 2006
- Article first published online: 6 JAN 2006
- Manuscript Received: 9 NOV 2005
- Manuscript Accepted: 12 SEP 2005
- Manuscript Revised: 27 AUG 2005
Funded by
- Intractable Hepatitis Study Group of Japan
REFERENCES
- 1, . Malignant liver tumors. In: SherlockS, DooleyJ, editors. Disease of the liver and biliary system. Oxford: Blackwell Science, 2002: 537–561.
- 2The Liver Cancer Study Group of Japan. Predictive factors for long-term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. Cancer. 1994; 74: 2772–2780.
- 3, , . Vitamin K-dependent biosynthesis of γ-carboxyglutamic acid. Blood. 1999; 93: 1798–1808.
- 4. The roles of vitamin D and vitamin K in bone health and osteoporosis prevention. Proc Nutr Soc. 1997; 56: 915–937.
- 5, , , . Vitamin K3 inhibition of malignant murine cell growth and human tumor colony formation. Cancer Treat Rep. 1985; 69: 527–532.
- 6, , , et al. Growth inhibition of hepatoma cells induced by vitamin K and its analogs. J Biol Chem. 1995; 270: 28304–28310.
- 7, , , et al. Novel role of vitamin K2: a potent inducer of differentiation of various human myeloid leukemia cell lines. Biochem Biophys Res Commun. 1994; 205: 1305–1310.
- 8, , . Comparison of antitumor activity of vitamins K1, K2, K3 on human tumor cells by two (MTT and SRB) cell viability assays. Life Sci. 1993; 52: 1797–1804.
- 9, , , . The growth inhibitory effects of vitamins K and their actions on gene expression. Hepatology. 1995; 22: 876–882.
- 10, , , , . Successful therapy of myelodysplastic syndrome with menatetrenone, a vitamin K2 analog. Int J Hematol. 1999; 69: 24–26.
- 11, , , et al. Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med. 1984; 310: 1427–1431.
- 12, , , et al. Clinicopathologic significance of protein induced vitamin K absence or antagonist II and alpha-fetoprotein in hepatocellular carcinoma. Int J Oncol. 1999; 14: 281–286.
- 13, , , et al. Des-γ-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma. A prospective analysis of 227 patients. Cancer. 2001; 91: 561–569.
- 14, , , , . Changes of plasma des-γ-carboxy-prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K. Cancer. 1992; 69: 31–38.
- 15, , , , , . Effects of menatetrenone on the bone and calcium metabolism in osteoporosis: a double-blind placebo-controlled study. J Bone Miner Metab. 1998; 16: 106–112.
- 16, , , et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol. 2001; 35: 421–430.
- 17, , , . Growth control and gene expression in a new hepatocellular carcinoma cell line, Hep40: inhibitory actions of vitamin K. J Cell Physiol. 1995; 165: 459–467.
- 18, , , , , . Geranylgeraniol is a potent inducer of apoptosis in tumor cells. J Biochem. 1995; 117: 11–13.
- 18, , , et al. Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. Ann Intern Med. 1999; 131: 174–181.
- 20, , , et al. Effects of long-term postoperative interferon-α therapy on intrahepatic recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. Ann Intern Med. 2001; 134: 963–967.
- 21, , , et al. The Hepatoma Prevention Study Group. Prevention of second primary tumor by an acyclic retinoid, polyrenoic acid, in patients with hepatocellular carcinoma. N Engl J Med. 1996; 334: 1561–1567.

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