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Fatigue in long-term breast carcinoma survivors
A longitudinal investigation
Version of Record online: 9 JAN 2006
Copyright © 2006 American Cancer Society
Volume 106, Issue 4, pages 751–758, 15 February 2006
How to Cite
Bower, J. E., Ganz, P. A., Desmond, K. A., Bernaards, C., Rowland, J. H., Meyerowitz, B. E. and Belin, T. R. (2006), Fatigue in long-term breast carcinoma survivors. Cancer, 106: 751–758. doi: 10.1002/cncr.21671
- Issue online: 3 FEB 2006
- Version of Record online: 9 JAN 2006
- National Cancer Institute. Grant Number: R01CA63028
- National Cancer Institute. Grant Number: K07 CA90407
- California Breast Cancer Research Program
- American Cancer Society Clinical Research Professorship
- breast carcinoma;
- cancer survivor;
- quality of life
A longitudinal study was designed to evaluate the prevalence, persistence, and predictors of posttreatment fatigue in breast carcinoma survivors.
A sample of 763 breast carcinoma survivors completed questionnaires at 1–5 and 5–10 years after diagnosis, including the RAND 36-item Health Survey, Center for Epidemiological Studies – Depression scale (CES-D), Breast Cancer Prevention Trial Symptom Checklist, and demographic and treatment-related measures.
Approximately 34% of study participants reported significant fatigue at 5–10 years after diagnosis, which is consistent with prevalence estimates obtained at 1–5 years after diagnosis. Approximately 21% reported fatigue at both assessment points, indicating a more persistent symptom profile. Longitudinal predictors of fatigue included depression, cardiovascular problems, and type of treatment received. Women treated with either radiation or chemotherapy alone showed a small improvement in fatigue compared with those treated with both radiation and chemotherapy.
Fatigue continues to be a problem for breast carcinoma survivors many years after cancer diagnosis, with 21% reporting persistent problems with fatigue. Several factors that may contribute to long-term fatigue are amenable to intervention, including depression and comorbid medical conditions. Cancer 2006. © 2006 American Cancer Society.