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Are venous thromboembolic events associated with subsequent breast and colorectal carcinoma diagnoses in the elderly?†
A case–control study of Medicare beneficiaries
Article first published online: 12 JAN 2006
Copyright © 2006 American Cancer Society
Volume 106, Issue 4, pages 923–930, 15 February 2006
How to Cite
Polite, B. N. and Lamont, E. B. (2006), Are venous thromboembolic events associated with subsequent breast and colorectal carcinoma diagnoses in the elderly?. Cancer, 106: 923–930. doi: 10.1002/cncr.21672
For this study, the linked Surveillance, Epidemiology, and End Results-Medicare data base was used. The interpretation and reporting of these data are the sole responsibility of the authors.
- Issue published online: 3 FEB 2006
- Article first published online: 12 JAN 2006
- Manuscript Accepted: 20 SEP 2005
- Manuscript Revised: 16 AUG 2005
- Manuscript Received: 22 MAR 2005
- National Institutes of Health. Grant Number: K07 CA93892
- venous thrombosis;
- pulmonary embolism;
- colorectal neoplasms;
- breast neoplasms
Multiple epidemiologic studies have reported associations between venous thromboembolic events and subsequent cancer diagnoses, but the published results have not suggested clear cancer screening approaches.
Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results-Medicare Program, the authors identified patients who were diagnosed with breast and colorectal carcinoma (n = 7166 patients) and compared them with a noncancer control group (n = 126,668 patients) according to their history of hospitalization for deep vein thrombosis (DVT) or pulmonary embolism (PE) in Medicare claims files over the previous 24 months. Using logistic regression analysis, the authors calculated the odds of receiving a diagnosis of breast carcinoma or colorectal carcinoma in the 24 months after admission for DVT or PE.
Patients who were hospitalized for DVT or PE had nearly 3.0 times the odds of being diagnosed with colorectal carcinoma (odds ratio [OR], 2.83; 95% confidence interval [95% CI], 1.92–4.17) and > 1.5 times the odds of being diagnosed with breast carcinoma (OR, 1.78; 95% CI, 1.05–3.02) in the subsequent 24 months.
Because hospitalization for DVT or PE is associated with an increased risk of a breast or colorectal carcinoma diagnosis in the subsequent 2 years, physicians should be vigilant in assessing the cancer screening status of patients with new DVT and/or PE to be certain that they are up to date with recommended breast and colorectal screening guidelines. Cancer 2006. © 2006 American Cancer Society.