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Differences in clinical characteristics and disease-free survival for Latino, African American, and non-Latino white men with localized prostate cancer
Data from CaPSURE™
Article first published online: 6 JAN 2006
Copyright © 2006 American Cancer Society
Volume 106, Issue 4, pages 789–795, 15 February 2006
How to Cite
Latini, D. M., Elkin, E. P., Cooperberg, M. R., Sadetsky, N., DuChane, J., Carroll, P. R. and CaPSURE™ Investigators (2006), Differences in clinical characteristics and disease-free survival for Latino, African American, and non-Latino white men with localized prostate cancer. Cancer, 106: 789–795. doi: 10.1002/cncr.21675
- Issue published online: 3 FEB 2006
- Article first published online: 6 JAN 2006
- Manuscript Accepted: 13 SEP 2005
- Manuscript Revised: 28 JUL 2005
- Manuscript Received: 26 MAY 2005
- TAP Pharmaceutical Products Inc. (Lake Forest, IL)
- National Cancer Institute of the National Institutes of Health, University of California-San Francisco SPORE Special Program of Research Excellence. Grant Number: P50 C89520
- prostatic neoplasms;
- longitudinal analysis
Few studies of ethnicity and prostate cancer have included Latino men in analyses of baseline clinical characteristics, treatment selection, and disease-free survival (DFS). The present study examines the impact of Latino ethnicity on these parameters in a large, multiinstitutional database of men with prostate cancer.
We compared baseline disease characteristics and clinical outcomes for Latino (N = 138), non-Latino White (NLW, N = 5619), and African-American (AA, N = 608) men with localized prostate cancer by using chi-square and ANOVA for baseline variables and survival analysis to examine differences in time to recurrence.
Latino men resembled AA men more than NLW on sociodemographic characteristics. AA men had higher Gleason scores and prostate-specific antigen (PSA) at diagnosis than Latino or NLW men (both P < 0.01). 10% of both Latino and AA men presented with advanced disease (T3b/T4/N+/M+) versus 4% of NLW (P < 0.01). Latino men did not receive different treatments than NLW or AA men after controlling for clinical and demographic factors; however, AA men were more likely to receive external beam radiation (OR = 1.51, 95% confidence interval [CI] = 0.99–2.31) and hormone treatment (OR = 1.56, 95% CI = 1.05–2.32) then NLW men. For prostatectomy patients, 3-year actuarial DFS rates were 83% for NLW men and 86% for Latino men versus 69% for AA men (P < 0.01). After controlling for clinical and sociodemographic variables, AA men were somewhat more likely than NLW to experience disease recurrence after radical prostatectomy (RP) (HR = 1.38, 95% CI = 0.98–1.94, P = 0.06).
Latinos are more similar to African Americans on sociodemographic characteristics but more similar to NLW on clinical presentation, treatments received, and DFS. Cancer 2006. © 2006 American Cancer Society.