Current status of lymph node-positive prostate cancer

Incidence and predictors of outcome

Authors

  • Gregory P. Swanson MD,

    Corresponding author
    1. Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
    2. Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
    • Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive MC 7889, San Antonio TX 78229
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    • Fax: (210) 949-5085

  • Ian M. Thompson MD,

    1. Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
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  • Joseph Basler MD

    1. Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
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Abstract

In early surgical series, the incidence of positive lymph nodes in patients with prostate cancer was approximately 40%. In the modern era of screening and improved patient selection, the incidence is now <10%, although most series excluded patients with higher risk disease. The risk of having positive lymph nodes is influenced by disease stage, prostate-specific antigen level, and tumor grade and by the aggressiveness of lymph node dissection. Many of the same factors predict the outcome of these patients. Although the percentage of patients with positive lymph nodes has declined, there remain significant numbers of patients with lymph node-positive prostate cancer, and it remains a therapeutic dilemma. Cancer 2006. © 2006 American Cancer Society.

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