Dr. Catherine Schairer had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Article first published online: 31 JUL 2006
Published 2006 American Cancer Society
Volume 107, Issue 5, pages 1075–1083, 1 September 2006
How to Cite
Kazerouni, N., Greene, M. H., Lacey, J. V., Mink, P. J. and Schairer, C. (2006), Family history of breast cancer as a risk factor for ovarian cancer in a prospective study. Cancer, 107: 1075–1083. doi: 10.1002/cncr.22082
The opinions or assertions contained herein are the personal conclusions of the authors and are not to be construed as official or reflecting the views of any state agency listed above.
This article is a US Government work and, as such, is in the public domain in the United States of America.
- Issue published online: 21 AUG 2006
- Article first published online: 31 JUL 2006
- Manuscript Accepted: 3 MAY 2006
- Manuscript Revised: 14 APR 2006
- Manuscript Received: 25 JAN 2006
- Intramural Research Program of the National Cancer Institute
- breast cancer;
- family history;
- ovarian cancer
A family history of breast cancer has been associated with increased ovarian cancer risk. However, few studies have assessed risk according to characteristics that suggest an inherited cancer susceptibility disorder, such as earlier-than-usual age at cancer diagnosis, family members with double primary cancers of different types, multiple relatives with cancer, and cancer in both members of paired organs.
Ovarian cancer risk was assessed according to a detailed breast cancer family history among 49,975 participants in the Breast Cancer Detection Demonstration Project Breast Cancer Defection Demenstration Project (BCDDP) Follow-up Study (1979–1998). In all, 362 incident ovarian cancers were identified during follow-up and rate ratios (RRs) were calculated by Poisson regression.
Breast cancer in a first- or second-degree relative was associated with increased risk of ovarian cancer (RR = 1.4; 95% confidence interval [CI] = 1.1–1.7). Having 2 or more affected first-degree relatives was associated with increased risk (RR = 1.8; 95% CI = 1.1–2.8), especially for women diagnosed with ovarian cancer before age 60 (RR = 4.2; 95% CI = 1.9–9.2) or with a personal history of breast cancer (RR = 3.7; 95% CI 1.8–7.7). Risk was also particularly high for women with 2 or more first-degree relatives with breast cancer and at least 1 affected relative diagnosed before age 50 (RR = 2.6; 95% CI = 1.4–4.8) or with bilateral breast cancer (RR = 4.2; 95% CI = 1.7–10).
A detailed breast cancer family history as well as an individual's age and personal history of breast cancer are useful for identifying women at elevated genetic risk of ovarian cancer. Cancer 2006. Published 2006 by the American Cancer Society.