Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia

Correlation with response and direct thermometry

Authors

  • Johanna Gellermann MD,

    1. Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
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    • The first 2 authors contributed equally to this paper.

  • Bert Hildebrandt MD,

    1. Clinic for Medicine, Hematology and Medical Oncology, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
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    • Fax: 011 (49) 30450557979.

  • Rolf Issels MD,

    1. Medical Clinic III, University Hospital Medical Center Grosshadern, Munich, Germany
    2. National Research Center for Environment and Health, Institute for Molecular Immunology, Munich, Germany
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  • Hildegard Ganter MD,

    1. Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
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  • Waldemar Wlodarczyk PhD,

    1. Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
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  • Volker Budach MD,

    1. Clinic for Radiotherapy, University Hospital Charite, Campus Mitte, Berlin, Germany
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  • Roland Felix MD,

    1. Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
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  • Per-Ulf Tunn MD,

    1. Department of Surgery and Surgical Oncology, University Hospital Charite, Campus Berlin-Buch, Berlin, Germany
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  • Peter Reichardt MD,

    1. Clinic for Medicine, Hematology and Medical Oncology, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
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  • Peter Wust MD

    Corresponding author
    1. Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Berlin, Germany
    • Clinic for Radiation Medicine, University Hospital Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
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    • Fax: 011 (49) 30450557979.


Abstract

BACKGROUND

The objective of this study was to evaluate noninvasive magnetic resonance (MR) thermography for the monitoring of regional hyperthermia (RHT) in patients with soft tissue sarcomas of the lower extremities and pelvis.

METHODS

Noninvasive MR monitoring during RHT was performed in 9 patients who had high-risk soft tissue sarcomas of the lower extremities or pelvis during neoadjuvant chemotherapy plus RHT in the scope of the European Organization for Research and Treatment of Cancer 62961/European Society for Hyperthermic Oncology RHT-95 study. Anatomic and temperature-sensitive data sets were acquired every 10 minutes before and during RHT (using gradient-echo-sequences with variable echo times). MR temperature distributions were derived from the phase differences by using the proton-resonance frequency shift method. A phase convolution setting phase shifts to zero in the fat tissue was performed as a drift correction. The mean MR temperatures in the tumor and muscles and the index temperatures (e.g., T90, which covers 90% of the target volume) and thermal doses were determined and compared with pathohistologic responses and direct temperature measurements if available.

RESULTS

Thirty of 72 MR-thermography data sets (>40% of heat sessions) were evaluable. A significant correlation was observed between pathohistologic response (defined as a necrosis rate ≥90%) and standardized thermal parameters, such as thermal dose cumulative equivalent minutes at 43°C to 90% of the target volume (T90) (P = .050), mean T90 (P = .048), or T50 (P = .050). The correlation of 13 conventional temperature measurements performed in selected patients and sessions invasively in the tumor or noninvasively in rectum and bladder revealed an excellent correlation with MR temperatures (R2 = .96).

CONCLUSIONS

Noninvasive MR thermography of soft tissue sarcoma was feasible and suitable for validating the quality of heating during RHT. Cancer 2006. © 2006 American Cancer Society.

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