Increased expression of avian erythroblastosis virus E26 oncogene homolog 1 in World Health Organization grade 1 meningiomas is associated with an elevated risk of recurrence and is correlated with the expression of its target genes matrix metalloproteinase-2 and MMP-9

Authors

  • Ali Fuat Okuducu MD,

    Corresponding author
    1. Institute of Neuropathology, Charite-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
    • Institute of Neuropathology, Charite-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin, D-13353 Germany
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    • Fax: 011 (49) 30450536940.

  • Ulrich Zils MD,

    1. Institute of Neuropathology, Charite-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
    2. Department of Neurosurgery, Charite-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
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  • Silke A. M. Michaelis MD, MRCOG,

    1. Institute of Neuropathology, Charite-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
    Current affiliation:
    1. Department of Obstetrics, Charite-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
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  • Christian Mawrin MD,

    1. Institute of Neuropathology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
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  • Andreas von Deimling MD

    1. Institute of Neuropathology, Charite-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany
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Abstract

BACKGROUND

The transcription factor avian erythroblastosis virus E26 (V-Ets) oncogene homolog 1 (Ets-1) is involved in tumor development and progression through the transcriptional regulation of several matrix-degrading enzyme systems, including matrix metalloproteinases (MMPs). It has been demonstrated that the MMPs are expressed strongly in high-grade meningiomas. To determine the biologic significance of Ets-1 in the progression of benign meningiomas, the authors investigated the expressions of Ets-1 and its target genes MMP-2 and MMP-9 in primary and recurrent, Grade 1 meningiomas.

METHODS

The expression levels of Ets-1, MMP-2, and MMP-9 were examined by immunohistochemistry in 70 Grade 1 meningiomas, including 36 primary tumors without recurrence after 5 years of follow-up and 17 pairs of primary tumors and subsequent recurrences.

RESULTS

The results demonstrated higher expression of Ets-1, MMP-2, and MMP-9 proteins in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences (P < .001). In addition, Ets-1 expression was correlated with the expression of both MMP-2 and MMP-9.

CONCLUSIONS

Ets-1 may be involved in meningioma recurrence by up-regulating MMP-2 and MMP-9. Increased expression of these genes in World Health Organization grade 1 meningiomas may serve as an indicator for a high risk of recurrence. Cancer 2006. © 2006 American Cancer Society.

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