This work was performed in partial fulfillment of the requirements for the PhD degree of Anat Ohali, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Telomere length is a prognostic factor in neuroblastoma
Article first published online: 17 AUG 2006
Copyright © 2006 American Cancer Society
Volume 107, Issue 6, pages 1391–1399, 15 September 2006
How to Cite
Ohali, A., Avigad, S., Ash, S., Goshen, Y., Luria, D., Feinmesser, M., Zaizov, R. and Yaniv, I. (2006), Telomere length is a prognostic factor in neuroblastoma. Cancer, 107: 1391–1399. doi: 10.1002/cncr.22132
- Issue published online: 1 SEP 2006
- Article first published online: 17 AUG 2006
- Manuscript Revised: 17 MAY 2006
- Manuscript Accepted: 17 MAY 2006
- Manuscript Received: 21 MAR 2006
- Josefina Maus and Gabriela Cesarman Maus Chair for Pediatric Hematology Oncology
- Rosenzweig-Coopersmith Foundation
Maintenance of telomeres, in most instances by reactivation of telomerase, is obligatory for the indefinite proliferation of tumor cells. The objective of this study was to evaluate telomere length and telomerase activity (TA) as markers for progression and prognosis in neuroblastoma.
Primary tumor samples from 51 patients were analyzed for telomere length and TA and were correlated with known prognostic parameters and outcome.
Telomere length had a highly significant correlation with prognosis (P = .007). Short telomeres were predictive of a favorable prognosis, whereas long or unchanged telomeres were predictive of a poor outcome. For the first time to their knowledge, the authors have shown that, within the high-risk group patients, telomere length could define a favorable subgroup that had a progression-free survival (PFS) rate of 86% compared with a PFS rate of 36% for patients with more adverse disease, which is the expected PFS rate for such patients (P = .04). In a multivariate analysis, telomere length was the most significant prognostic parameter (P = .032). TA was correlated significantly with outcome and with known prognostic factors. High TA and low TA were associated with adverse and favorable outcomes, respectively (P = .01).
The results of this investigation suggested that telomere length is a highly significant prognostic parameter of clinical relevance in patients with neuroblastoma. In high-risk patients, telomere length was the sole significant parameter that identified a group of patients who had a favorable prognosis. The authors suggest that telomere length should be included in the recommended diagnostic investigations for patients with neuroblastoma. Cancer 2006. © 2006 American Cancer Society.