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Original Article
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Recreational physical activity and survival among young women with breast cancer†‡
Article first published online: 11 SEP 2006
DOI: 10.1002/cncr.22201
Published 2006 American Cancer Society
Additional Information
How to Cite
Abrahamson, P. E., Gammon, M. D., Lund, M. J., Britton, J. A., Marshall, S. W., Flagg, E. W., Porter, P. L., Brinton, L. A., Eley, J. W. and Coates, R. J. (2006), Recreational physical activity and survival among young women with breast cancer. Cancer, 107: 1777–1785. doi: 10.1002/cncr.22201
- †
The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the National Institutes of Health.
- ‡
This article is a US Government work and, as such, is in the public domain in the United States of America.
Publication History
- Issue published online: 3 OCT 2006
- Article first published online: 11 SEP 2006
- Manuscript Accepted: 20 JUL 2006
- Manuscript Revised: 17 JUL 2006
- Manuscript Received: 19 MAY 2006
Funded by
- Public Health Service. Grant Numbers: P30ES10126, R25 CA57726, R25 CA94880
- Intramural Research Program of the National Institutes of Health, National Cancer Institute
- Abstract
- Article
- References
- Cited By
Keywords:
- breast cancer;
- survival;
- mortality;
- physical activity;
- exercise
The authors investigated whether recreational physical activity undertaken prior to diagnosis influenced breast cancer survival among a population-based cohort of 1264 young women. Some evidence was observed for a beneficial effect on survival of activity undertaken in the year prior to diagnosis, particularly among women who were overweight or obese near the time of diagnosis.
Abstract
BACKGROUND
Most epidemiologic studies report a reduced risk of developing breast cancer associated with higher levels of recreational physical activity, but little is known regarding its effect on prognosis.
METHODS
In this study, the authors investigated whether activity undertaken prior to diagnosis influenced breast cancer survival in a population-based cohort. A follow-up study was conducted among 1264 women ages 20 to 54 years who were diagnosed with invasive breast cancer between 1990 and 1992. Women in the study were interviewed within several months of diagnosis and were asked about their average frequency of moderate and vigorous activity at age 13 years, age 20 years, and during the year before diagnosis. With 8 to 10 years of follow-up, all-cause mortality status was determined by using the National Death Index (n = 290 deaths).
RESULTS
A modest reduction in the hazards ratio (HR) was observed for the highest quartile of activity in the year before diagnosis compared with the lowest quartile (stage-adjusted and income-adjusted HR, 0.78; 95% confidence interval [95% CI], 0.56–1.08). High activity was associated with a reduced HR among women who were overweight or obese at the time of diagnosis (HR, 0.70; 95% CI, 0.49–0.99) but not among ideal weight or underweight women (HR, 1.08; 95% CI, 0.77–1.52). A reduced HR was not evident for activity at age 13 years or 20 years or for average activity across the 3 periods studied.
CONCLUSIONS
The results of this study provided some suggestive evidence for a beneficial effect on survival of recreational physical activity undertaken in the year before diagnosis, particularly among women who are overweight or obese near the time of diagnosis. Cancer 2006. Published 2006 by the American Cancer Society.