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Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma†
Article first published online: 20 OCT 2006
DOI: 10.1002/cncr.22295
Copyright © 2006 American Cancer Society
Additional Information
How to Cite
Kruper, L. L., Spitz, F. R., Czerniecki, B. J., Fraker, D. L., Blackwood-Chirchir, A., Ming, M. E., Elder, D. E., Elenitsas, R., Guerry, D. and Gimotty, P. A. (2006), Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma. Cancer, 107: 2436–2445. doi: 10.1002/cncr.22295
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Presented in part at the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, FL, May 13–17, 2005.
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Fax: (215) 573-4865
Publication History
- Issue published online: 8 NOV 2006
- Article first published online: 20 OCT 2006
- Manuscript Accepted: 7 SEP 2006
- Manuscript Revised: 1 SEP 2006
- Manuscript Received: 24 FEB 2006
Funded by
- SPORE on Skin Cancer. Grant Number: CA-093372
- NRSA Cancer Epidemiology Training. Grant Number: T32 CA-009679
REFERENCES
- 1, , , et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 2001; 19: 3635–3648.
- 2, , , et al. Technical details of intraoperative lymphatic mapping for early-stage melanoma. Arch Surg. 1992; 127: 392–399.
- 3, , , et al. Sentinel-node biopsy or nodal observation in melanoma. NEJM. 2006; 355: 1307–1317.
- 4National Comprehensive Cancer Network: melanoma: clinical practice guidelines in oncology. v. 1. 2005. Available at http://www.nccn.org/professionals/physician_gls/PDF/melanoma.pdf
- 5, , , et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel node status in 612 stage I or II melanoma patients. J Clin Oncol. 1999; 17: 976–983.
- 6, , , et al. Sentinel lymph node biopsy for melanoma: controversy despite widespread agreement [Commentary]. J Clin Oncol. 2001; 19: 2851–2855.
- 7, , , et al. Factors that predict the presence of sentinel node metastasis in patients with melanoma. Surgery. 2001; 130: 151–156.
- 8, , , et al. Prediction of sentinel node micrometastasis by histological features in primary cutaneous malignant melanoma. Arch Dermatol. 1998; 134: 983–987.
- 9, , , et al. Sentinel lymph node biopsy in patients with primary cutaneous melanoma: study of 455 cases. J Eur Acad Dermatol Venereol. 2000; 14: 35–45.
- 10, , , et al. Sentinel lymph node biopsy in cutaneous melanoma: the WHO Melanoma Program experience. Ann Surg Oncol. 2000; 7: 469–474.
- 11, , , et al. Melanoma thickness and histology predict sentinel lymph node status. Am J Surg. 2001; 181: 8–11.
- 12, , , et al. Revised American Joint Committee on Cancer staging criteria accurately predict sentinel lymph node positivity in clinically node-negative melanoma patients. Ann Surg Oncol. 2003; 10: 569–574.
- 13, , , et al. Predicting sentinel and residual lymph node basin disease after sentinel lymph node biopsy for melanoma. Cancer. 2000; 89: 453–462.
- 14, , , et al. Mitotic rate and younger age are predictors of sentinel lymph node positivity: lessons learned from the generation of a probabilistic model. Ann Surg Oncol. 2004; 11: 247–258.
- 15, , , et al. Sentinel lymph node biopsy for cutaneous melanoma: the Stanford experience, 1997–2004. Arch Dermatol. 2005; 141: 1016–1022.
- 16, , , et al. Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma. Ann Surg. 2003; 238: 538–550.
- 17, , , et al. Sentinel node status in melanoma patients is not predictive for overall survival upon multivariate analysis. Br J Cancer. 2005; 92: 662–667.
- 18, , , et al. Significance of multiple modal basin drainage in truncal melanoma patients undergoing sentinel lymph node biopsy. Ann Surg Oncol. 2000; 7: 256–261.
- 19, , , et al. Incidence of sentinel node metastasis in patients with thin primary melanoma (≤1mm) with vertical growth phase. Ann Surg Oncol. 2000; 7: 262–267.
- 20, , , et al. Patterns of initial recurrence and prognosis after sentinel lymph node biopsy and selective lymphadenectomy for melanoma. Plast Reconstr Surg. 2003; 112: 486–497.
- 21, , , et al. Model predicting survival in Stage I melanoma based on tumor progression. J Natl Cancer Inst. 1989; 81: 1893–1904.
- 22, , , et al. Invasive malignant melanomas lacking competence for metastasis. Am J Dermatopathol. 1984; 6: 55S–61S.
- 23, , . Cutaneous melanoma: estimating survival and recurrence risk based on histopathologic features. Dermatol Ther. 2005; 18: 368–384.Direct Link:
- 24, , , et al. Lessons learned from tumor progression: the invasive radial growth phase of melanoma is common, incapable of metastasis, and indolent. J Invest Dermatol. 1993; 100: 342S–345S.
- 25, , , et al. Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas. Ann Surg Oncol. 2005; 12: 449–458.
- 26, , , et al. Patterns of human tumor-infiltrating lymphocytes in 120 human cancers. Arch Surg. 1990; 125: 200–205.
- 27, , , et al. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer. 1996; 77: 1303–1310.
- 28, , . Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response. Lab Invest. 1996; 74: 43–47.
- 29, , , et al. Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol. 2003; 163: 1765–1770.
- 30, , , et al. Risk assessment in localized primary cutaneous melanoma. Am J Clin Pathol. 2002; 118: 504–511.
- 31, , , et al. Sentinel lymph node biopsy for melanoma: how many radioactive nodes should be removed? Ann Surg Oncol. 2001; 8: 192–197.
- 32
- 33Stata statistical software: release 8.0. College Station, TX: STATA, 2003.
- 34, CART: Tree-structured non-parametric data analysis. San Diego: Salford Systems, 1995.
- 35, , , et al. Classification and regression trees. Boca Raton, FL: Chapman and Hall, 1984.
- 36, , , et al. Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma. J Clin Oncol. 2005; 23: 8048–8056.
- 37, , , et al. A nomogram that predicts the presence of sentinel node metasasis in melanoma with better discrimination than the American Joint Committee on Cancer Staging System. Ann Surg Oncol. 2005; 282–288.
- 38Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) Public-Use Data (1973–2003), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2006, based on the November 2005 submission.
- 39, , , et al. Role of sentinel lymphadenectomy in thin invasive cutaneous melanomas. J Clin Oncol. 2003; 21: 1326–1331.
- 40, , . Role of sentinel lymph node biopsy in patients with thin (≤1mm) primary melanoma. Ann Surg Oncol. 2003; 10: 558–556.
- 41, , , et al. Thin primary cutaneous malignant melanoma: a prognostic tree for 10-year metastasis is more accurate than American Joint Committee on Cancer staging. J Clin Oncol. 2004; 22: 3668–3676.
- 42, , . Cutaneous melanoma: estimating survival and recurrence based on histopathologic features. Dermatol Ther. 2005; 18: 369–385.Direct Link:

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