Fax: (011) 81-4-7134-7026.
Original Article
You have full text access to this OnlineOpen article
Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy
Article first published online: 27 NOV 2006
DOI: 10.1002/cncr.22368
Copyright © 2006 American Cancer Society
Additional Information
How to Cite
Inagaki, M., Yoshikawa, E., Matsuoka, Y., Sugawara, Y., Nakano, T., Akechi, T., Wada, N., Imoto, S., Murakami, K., Uchitomi, Y. and and The Breast Cancer Survivors' Brain MRI Database Group (2007), Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer, 109: 146–156. doi: 10.1002/cncr.22368
Publication History
- Issue published online: 11 DEC 2006
- Article first published online: 27 NOV 2006
- Manuscript Accepted: 6 OCT 2006
- Manuscript Revised: 4 OCT 2006
- Manuscript Received: 6 SEP 2006
Funded by
- Japanese Ministry of Health, Labor, and Welfare
- Japan Society for the Promotion of Science
- Japanese Ministry of Education, Culture, Science, and Technology
- Foundation for Promotion of Cancer Research in Japan
REFERENCES
- 1, . Adjuvant breast cancer treatment and cognitive function: current knowledge and research directions. J Natl Cancer Inst. 2003; 95: 190–197.
- 2, , , , , . ‘Chemobrain’ in breast carcinoma? A prologue. Cancer. 2004; 101: 466–475.Direct Link:
- 3, , , , . A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function. Cancer. 2005; 104: 2222–2233.Direct Link:
- 4, , , , . The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: a meta-analysis of the current literature. Brain Cogn. 2005; 59: 60–70.
- 5, , , , . Neuropsychological effects of treatments for adults with cancer: a meta-analysis and review of the literature. J Int Neuropsychol Soc. 2003; 9: 967–982.
- 6
- 7, . Neurotoxicity secondary to antineoplastic drugs. Cancer Treat Rev. 1994; 20: 191–214.
- 8, , , et al. Cisplatin-based therapy: a neurological and neuropsychological review. Psychooncology. 2000; 9: 29–39.
- 9, , , , , . 5-fluorouracil-induced leukoencephalopathy in patients with breast cancer. J Korean Med Sci. 2001; 16: 328–334.
- 10, , . Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives. Semin Clin Neuropsychiatry. 2003; 8: 201–216.
- 11, . The impact of adjuvant therapy for breast cancer on cognitive function: current evidence and directions for research. Semin Oncol. 2003; 30: 749–762.
- 12, , , , . Hippocampal brain amines in methotrexate-induced learning and memory deficit. Can J Physiol Pharmacol. 2002; 80: 1076–1084.
- 13, , . Evidence on the retrograde neurotoxicity of doxorubicin. Neurosci Lett. 1985; 53: 215–219.
- 14, , , et al. Anticancer agents are potent neurotoxins in vitro and in vivo. Ann Neurol. 2004; 56: 351–360.Direct Link:
- 15, , , et al. Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: insight into chemobrain. Free Radic Res. 2005; 39: 1147–1154.
- 16, , , et al. No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors. Breast Cancer Res Treat. 2005; 92: 81–84.
- 17, , , et al. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol. 2002; 20: 485–493.
- 18, , , et al. Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study. J Clin Oncol. 2005; 23: 8025–8032.
- 19, , , et al. Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients. Ann Oncol. 2002; 13: 1387–1397.
- 20, , , , . The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer. 2004; 100: 2292–2299.Direct Link:
- 21, , . “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12: 189–198.
- 22, , . [ Usefulness of a Japanese version of the Mini-Mental State in neurological patients]. (Japanese). Shinkeishinrigaku. 1985; 1: 82–90.
- 23. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry. 2000; 57: 925–935.
- 24. Wechsler Memory Scale-Revised. New York: Psychological Corp; 1987.
- 25. Wechsler Memory Scale-Revised (Japanese). Tokyo: Nihonbunkakagakusya; 2001.
- 26, . Simultaneous confirmatory factor analysis of the Wechsler memory scale – revised for two standardization samples: a comparison of groups from Japan and the United States. J Clin Exp Neuropsychol. 2004; 26: 645–652.
- 27, . Voxel-based morphometry-the methods. Neuroimage. 2000; 11(6 pt 1): 805–821.
- 28, , , , , . A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 2001; 14(1 pt 1): 21–36.
- 29, , , , , . Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage. 2001; 14: 685–700.
- 30, , , , . Incorporating prior knowledge into image registration. Neuroimage. Nov 1997; 6: 344–352.
- 31, . Nonlinear spatial normalization using basis functions. Hum Brain Mapp. 1999; 7: 254–266.Direct Link:
- 32, , , , , . A unified statistical approach for determining significant voxels in images of cerebral activation. Hum Brain Mapp. 1996; 4: 58–73.Direct Link:
- 33, , , , . Detecting activations in PET and fMRI: levels of inference and power. Neuroimage. Dec 1996; 4(3 pt 1): 223–235.
- 34, , . The problem of functional localization in the human brain. Nat Rev Neurosci. 2002; 3: 243–249.
- 35. Mapping prefrontal cortical systems for the control of cognition. In: TogaAW, MazziottaJC, eds. Brain mapping: the systems. 1st ed. New York: Academic Press; 2000: 159–176.
- 36, . Parahippocampal region: organization and role in cognitive functions. New York and London: Oxford University Press; 2002.
- 37, . The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006; 129(pt 3): 564–583.

1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470)