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Predictive and discriminating three-risk-group prognostic scoring system for staging Hodgkin lymphomas

  1. Delphine Maucort-Boulch MD, MSc1,
  2. Malika Djeridane MD2,
  3. Pascal Roy MD, PhD1,
  4. Benjamin Riche MSc1,
  5. Pierre Colonna MD2,
  6. Jean-Marie Andrieu MD2,†,*

Article first published online: 7 DEC 2006

DOI: 10.1002/cncr.22394

Issue

Cancer

Cancer

Volume 109, Issue 2, pages 256–264, 15 January 2007

Additional Information

How to Cite

Maucort-Boulch, D., Djeridane, M., Roy, P., Riche, B., Colonna, P. and Andrieu, J.-M. (2007), Predictive and discriminating three-risk-group prognostic scoring system for staging Hodgkin lymphomas. Cancer, 109: 256–264. doi: 10.1002/cncr.22394

Author Information

  1. 1

    Service de Biostatistique, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon et Laboratoire Biostatistique Sante, equipe UMR CNRS 5558, Lyon, France

  2. 2

    Reseau Lymphomes de Hodgkin du Groupe Ouest Est des Leucemies et Autres Maladies du Sang (GOELAMS), Universite Rene Descartes-Paris 5, and Assistance Publique, Hopitaux de Paris, Hopital European Georges Pompidou, Service de Cancerologie Medicale, Paris, France

  1. †

    Fax: (011) 33 1 56 09 24 15.

*Oncologie Medicale, Hopital European Georges Pompidou, 75015 Paris, France

  1. †

    Fax: (011) 33 1 56 09 24 15.

Publication History

  1. Issue published online: 8 JAN 2007
  2. Article first published online: 7 DEC 2006
  3. Manuscript Revised: 13 OCT 2006
  4. Manuscript Accepted: 13 OCT 2006
  5. Manuscript Received: 15 SEP 2006

Funded by

  • AREMAS, Paris

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Keywords:

  • Hodgkin lymphoma;
  • staging;
  • prognosis

Abstract

BACKGROUND.

Several 3-stage Ann Arbor classification-derived prognostic systems were constructed since 1980 to identify the prognosis of Hodgkin lymphoma (HL). Modern statistical tools were applied to 955 patients treated between 1981 and 1996 to build a 3-stage prognostic scoring system (PSS).

METHODS.

Each variable associated with 10-year overall survival (10-year OS) was assigned to 2 (0 or 1) or 3 (0, 1 or 3) values. By summing the values attributed to each variable, 3 stages were defined. 10-year OS, 5-year event-free survival (5-year EFS), and freedom from progression (5-year FFP) rates of the PSS and of other existing systems were then compared.

RESULTS.

Four variables were associated with 10-year OS: age (<40 = 0, ≥40 = 1), number of involved lymphoid areas (1–2 = 0, 3–4 = 1, ≥5 = 2), visceral disease (no = 0, yes = 1), and systemic symptoms (no = 0, yes = 1). Scores 0 and 1, 2 and 3, and ≥4 were attributed to 59.7%, 30.9%, and 9.4% of the patients who had 10-year OS rates of 93.5, 75.7, and 53.4% and 5-year EFS / 5-year FFP rates of 91.2%/90.3%, 78.1%/76.3%, and 54.1%/52.6%, respectively. The discrimination and prediction abilities of the PSS were better than those of the other systems tested; moreover, the PSS adequately identified the few patients with a worse prognosis without resorting to the International Prognostic Score for advanced stages. The PSS was also highly predictive for 489 patients treated between 1997 and 2002.

CONCLUSION.

PSS is a useful alternative to the existing prognostic systems for evaluating HL patients. Cancer 2007. © 2006 American Cancer Society.

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